Fzd1
Gene Detail

Symbol Name ID

Fzd1 frizzled homolog 1 (Drosophila) MGI:1196625

Synonyms

Fz1, FZ-1

Feature Type

protein coding gene

Genetic Map

Chromosome 5

2.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr5:4753873-4758035 bp, - strand From VEGA annotation of GRCm38   4163 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20750  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: G protein-coupled receptor frizzled
Gene Tree: Fzd1

Human homologs

Human Homolog		FZD1, frizzled family receptor 1
NCBI Gene ID		8321
neXtProt AC		NX_Q9UP38
Human Chr (Location)		7q21; chr7:90893783-90898132 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Homozygous mutation of this gene does not appear to result in a phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (60 annotations)

Process	autocrine signaling, axonogenesis, ...
Component	apical part of cell, cell surface, ...
Function	G-protein coupled receptor activity, PDZ domain binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (36 records)
Data Summary: Results (615)    Tissues (316)    Images (181)
Theiler Stages: 1, 2, 3, 4, 5, 13, 14, 15, 17, 19, 20, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	6
RNA in situ	383
In situ reporter (knock in)	129
RT-PCR	97

cDNA source data(75)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(87) cDNA(76) Primer pair(10) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000021313 (Evidence)
Ensembl Gene Model	ENSMUSG00000044674 (Evidence)
Entrez Gene	14362 (Evidence)
UniGene	246003
DFCI	TC1576237, TC1691698
DoTS	DT.526604, DT.94316721
NIA Mouse Gene Index	U005275
Consensus CDS Project	CCDS19072.1
International Mouse Knockout Project Status	Fzd1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021313	VEGA Gene Model | MGI Sequence Detail	4163	C57BL/6J
transcript	OTTMUST00000050529	VEGA | MGI Sequence Detail	4163	Not Applicable
polypeptide	OTTMUSP00000023600	VEGA | MGI Sequence Detail	642	Not Applicable

All sequences(23) RefSeq(2) UniProt(1)

Polymorphisms

SNPs within 2kb(25 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR026548	Frizzled-1
InterPro	IPR020067	Frizzled domain
InterPro	IPR000539	Frizzled protein
InterPro	IPR015526	Frizzled/secreted frizzled-related protein
InterPro	IPR017981	GPCR, family 2-like
Protein Ontology	PR:000007718	frizzled-1

References

(Earliest) J:45301 Cygan JA, et al., Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants. Development. 1997 Dec;124(24):5021-32
(Latest) J:192479 Lapointe E, et al., FZD1 regulates cumulus expansion genes and is required for normal female fertility in mice. Biol Reprod. 2012 Nov;87(5):104
All references(73)

Other accession IDs

MGI:2141181