Fzd1 MGI Mouse Gene Detail - MGI:1196625 - frizzled class receptor 1

Fzd1 Gene Detail

Symbol

Fzd1
Name

frizzled class receptor 1
Synonyms

Fz1, FZ-1

Feature Type

protein coding gene
IDs

MGI:1196625
NCBI Gene: 14362
Gene Overview

MyGene.info: FZD1

Sequence Map

Chr5:4753839-4758035 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

4197 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 2.61 cM
Mapping Data

3 experiments

Human Ortholog

FZD1, frizzled class receptor 1

Vertebrate Orthologs

10

Human Ortholog

FZD1, frizzled class receptor 1
Orthology source: HomoloGene, HGNC
Links

HGNC:4038

NCBI Gene ID: 8321

neXtProt AC: NX_Q9UP38

UniProt: Q9UP38
Chr Location

7q21.13; chr7:91264468-91268817 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 20750
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 macaque, rhesus
HCOP

human homology predictions: FZD1
Protein SuperFamily

G protein-coupled receptor frizzled
Gene Tree

Fzd1

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Phenotype Summary

13 phenotypes from 3 alleles in 3 genetic backgrounds
17 phenotypes from multigenic genotypes
5 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

3
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

15 strains or lines available

Homozygous mutation of this gene does not appear to result in a phenotype.

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All GO Annotations

53
GO References

12

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

619
Tissues

320
cDNA Data

75
Literature Summary

48

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FZD1

Xenbase fzd1

ZFIN fzd1

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Fzd1 interacts with 240 markers (Mir1a-1, Mir1a-2, Mir15a, ...) View All

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All Sequences

18
RefSeq

2
UniProt

1
CCDS

CCDS19072.1
UniGene

246003

			Length	Strain/Species	Flank
genomic	OTTMUSG00000021313	VEGA Gene Model \| MGI Sequence Detail	4197	C57BL/6J	± kb
transcript	OTTMUST00000050529	VEGA \| MGI Sequence Detail	4197	Not Applicable
polypeptide	OTTMUSP00000023600	VEGA \| MGI Sequence Detail	642	Not Applicable

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SNPs within 2kb

26 from dbSNP Build 142

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UniProt

1 Sequence
Protein Ontology

PR:000007718 frizzled-1

(term hierarchy)
InterPro Domains

IPR026548 Frizzled-1

IPR020067 Frizzled domain

IPR015526 Frizzled/secreted frizzled-related protein

IPR000539 Frizzled/Smoothened, transmembrane domain

IPR017981 GPCR, family 2-like

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All nucleic 89

cDNA 76

Primer pair 12

Other 1

Microarray probesets 5

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MGI:2141181

Summaries

All 82

Developmental Gene Expression 48

Gene Ontology 12

Phenotypes 5
Earliest

J:45301 Cygan JA, et al., Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants. Development. 1997 Dec;124(24):5021-32
Latest

J:238422 Fumoto K, et al., Modulation of apical constriction by Wnt signaling is required for lung epithelial shape transition. Development. 2017 Jan 01;144(1):151-162

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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