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Fzd1
Gene Detail
 Symbol
Name
ID
Fzd1
frizzled homolog 1 (Drosophila)
MGI:1196625
Synonyms Fz1, FZ-1
Feature Type protein coding gene
Genetic Map
Chromosome 5
2.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:4753873-4758035 bp, - strand
From VEGA annotation of GRCm38

  4163 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20750  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: G protein-coupled receptor frizzled
Gene Tree: Fzd1

Human
homologs
Human Homolog FZD1, frizzled class receptor 1
NCBI Gene ID 8321
neXtProt AC  NX_Q9UP38
Human Chr (Location)  7q21; chr7:91264468-91268817 (+)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene does not appear to result in a phenotype.
 
Gene Ontology
(GO)
classifications
All GO classifications: (62 annotations)
Process autocrine signaling, axonogenesis, ...
Component apical part of cell, cell surface, ...
Function frizzled binding, G-protein coupled receptor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (38 records)
Data Summary: Results (620)    Tissues (321)    Images (182)
Theiler Stages: 1, 2, 3, 4, 5, 7, 9, 11, 13, 14, 15, 17, 19, 20, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 6
RNA in situ 383
In situ reporter (knock in) 129
RT-PCR 102
cDNA source data(75)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(88) cDNA(76) Primer pair(11) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000021313 (Evidence)
Ensembl Gene ModelENSMUSG00000044674 (Evidence)
Entrez Gene14362 (Evidence)
UniGene246003
DFCITC1576237, TC1691698
DoTSDT.526604, DT.94316721
NIA Mouse Gene IndexU005275
Consensus CDS ProjectCCDS19072.1
International Mouse Knockout Project StatusFzd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021313 VEGA Gene Model | MGI Sequence Detail 4163 C57BL/6J ±  kb
transcript OTTMUST00000050529 VEGA | MGI Sequence Detail 4163 Not Applicable 
polypeptide OTTMUSP00000023600 VEGA | MGI Sequence Detail 642 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026548 Frizzled-1
InterPro IPR020067 Frizzled domain
InterPro IPR000539 Frizzled protein
InterPro IPR015526 Frizzled/secreted frizzled-related protein
InterPro IPR017981 GPCR, family 2-like
Protein Ontology PR:000007718 frizzled-1
References (Earliest) J:45301 Cygan JA, et al., Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants. Development. 1997 Dec;124(24):5021-32
(Latest) J:202907 Grigoryan T, et al., Wnt/Rspondin/beta-catenin signals control axonal sorting and lineage progression in Schwann cell development. Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):18174-9
All references(75)
Other
accession IDs
MGI:2141181

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory