About   Help   FAQ
Fzd1 Gene Detail
Summary
  • Symbol
    Fzd1
  • Name
    frizzled class receptor 1
  • Synonyms
    Fz1, FZ-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196625
    NCBI Gene: 14362
  • Gene Overview
    MyGene.info: FZD1
  • Alliance
    gene page
Location & Maps
more
  • Genetic Map
    Chromosome 5, 2.61 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    FZD1, frizzled class receptor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FZD1, frizzled class receptor 1
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 8321
    neXtProt AC: NX_Q9UP38
    UniProt: Q9UP38

  • Chr Location
    7q21.13; chr7:91264468-91268817 (+)  GRCh38.p7
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 3 alleles in 3 genetic backgrounds
    17 phenotypes from multigenic genotypes
    5 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene does not appear to result in a phenotype.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    57
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    632
  • Tissues
    327
  • cDNA Data
    76
  • Literature Summary
    50
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000021313 VEGA Gene Model | MGI Sequence Detail 4197 C57BL/6J ±  kb
    transcript OTTMUST00000050529 VEGA | MGI Sequence Detail 4197 Not Applicable  
    polypeptide OTTMUSP00000023600 VEGA | MGI Sequence Detail 642 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      26 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 93
      cDNA 77
      Primer pair 13
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2141181
    References
    more
    • Summaries
      All 87
      Developmental Gene Expression 50
      Gene Ontology 13
      Phenotypes 5
    • Earliest
      J:45301 Cygan JA, et al., Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants. Development. 1997 Dec;124(24):5021-32
    • Latest
      J:253067 Sigal M, et al., Stromal R-spondin orchestrates gastric epithelial stem cells and gland homeostasis. Nature. 2017 Aug 24;548(7668):451-455
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.     		last database update
    09/11/2018
    MGI 6.12     		The Jackson Laboratory