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Fzd1
Gene Detail
Symbol

Name
ID
Fzd1
frizzled homolog 1 (Drosophila)
MGI:1196625
Synonyms
Fz1, FZ-1
Feature Type
protein coding gene
Genetic Map
Chromosome 5
2.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:4753873-4758035 bp, - strand
From VEGA annotation of GRCm38

  4163 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20750  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

HCOP human homology predictions: FZD1
Protein SuperFamily: G protein-coupled receptor frizzled
Gene Tree: Fzd1

Human
homologs
FZD1, frizzled class receptor 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 8321
neXtProt AC: NX_Q9UP38

Human Chr (Location): 7q21; chr7:91264468-91268817 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene does not appear to result in a phenotype.
 
Interactions
Fzd1 interacts with 240 markers (Mir1a-1, Mir1a-2, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (51 annotations)
Process autocrine signaling, canonical Wnt signaling pathway, ...
Component cell surface, focal adhesion, ...
Function frizzled binding, G-protein coupled receptor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (40 records)
Data Summary: Results (616)    Tissues (317)    Images (182)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 383
In situ reporter (knock in) 129
RT-PCR 98
cDNA source data(75)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA FZD1 ; Xenbase fzd1 ; ZFIN fzd1    NEW 
Molecular
reagents
All nucleic(88) cDNA(76) Primer pair(11) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000021313 (Evidence)
Ensembl Gene Model ENSMUSG00000044674 (Evidence)
Entrez Gene 14362 (Evidence)
UniGene 246003
DFCI TC1691698, TC1576237
DoTS DT.94316721, DT.526604
NIA Mouse Gene Index U005275
Consensus CDS Project CCDS19072.1
International Mouse Phenotyping Consortium Status Fzd1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021313 VEGA Gene Model | MGI Sequence Detail 4163 C57BL/6J ±  kb
transcript OTTMUST00000050529 VEGA | MGI Sequence Detail 4163 Not Applicable 
polypeptide OTTMUSP00000023600 VEGA | MGI Sequence Detail 642 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026548 Frizzled-1
InterPro IPR020067 Frizzled domain
InterPro IPR000539 Frizzled protein
InterPro IPR015526 Frizzled/secreted frizzled-related protein
InterPro IPR017981 GPCR, family 2-like
Protein Ontology PR:000007718 frizzled-1
References
(Earliest) J:45301 Cygan JA, et al., Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants. Development. 1997 Dec;124(24):5021-32
(Latest) J:214959 Lodato S, et al., Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons. Nat Neurosci. 2014 Aug;17(8):1046-54
All references(75)
Other
accession IDs
MGI:2141181

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory