Fzd1
Gene Detail

Symbol

Name
ID

Fzd1
frizzled homolog 1 (Drosophila)
MGI:1196625

Synonyms

Fz1, FZ-1

Feature Type

protein coding gene

Genetic Map

Chromosome 5
2.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr5:4753873-4758035 bp, - strand From VEGA annotation of GRCm38   4163 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:20750  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: G protein-coupled receptor frizzled
Gene Tree: Fzd1

Human
homologs

Human Homolog		FZD1, frizzled class receptor 1
NCBI Gene ID		8321
neXtProt AC		NX_Q9UP38
Human Chr (Location)		7q21; chr7:91264468-91268817 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous mutation of this gene does not appear to result in a phenotype.

 

Interactions

Fzd1 interacts with 240 markers (Mir1a-1, Mir1a-2, Mir15a, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (51 annotations)

Process	autocrine signaling, canonical Wnt signaling pathway, ...
Component	cell surface, focal adhesion, ...
Function	frizzled binding, G-protein coupled receptor activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (40 records)

Data Summary: Results (616)    Tissues (317)    Images (182)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	6
RNA in situ	383
In situ reporter (knock in)	129
RT-PCR	98

cDNA source data(75)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(88) cDNA(76) Primer pair(11) Other(1)
Microarray probesets(5)

Other database
links

VEGA Gene Model	OTTMUSG00000021313 (Evidence)
Ensembl Gene Model	ENSMUSG00000044674 (Evidence)
Entrez Gene	14362 (Evidence)
UniGene	246003
DFCI	TC1576237, TC1691698
DoTS	DT.94316721, DT.526604
NIA Mouse Gene Index	U005275
Consensus CDS Project	CCDS19072.1
International Mouse Knockout Project Status	Fzd1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021313	VEGA Gene Model | MGI Sequence Detail	4163	C57BL/6J
transcript	OTTMUST00000050529	VEGA | MGI Sequence Detail	4163	Not Applicable
polypeptide	OTTMUSP00000023600	VEGA | MGI Sequence Detail	642	Not Applicable

All sequences(23) RefSeq(2) UniProt(1)

Polymorphisms

SNPs within 2kb(25 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR026548	Frizzled-1
InterPro	IPR020067	Frizzled domain
InterPro	IPR000539	Frizzled protein
InterPro	IPR015526	Frizzled/secreted frizzled-related protein
InterPro	IPR017981	GPCR, family 2-like
Protein Ontology	PR:000007718	frizzled-1

References

(Earliest) J:45301 Cygan JA, et al., Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants. Development. 1997 Dec;124(24):5021-32
(Latest) J:214959 Lodato S, et al., Gene co-regulation by Fezf2 selects neurotransmitter identity and connectivity of corticospinal neurons. Nat Neurosci. 2014 Aug;17(8):1046-54
All references(77)

Other
accession IDs

MGI:2141181