Fzd1 MGI Mouse Gene Detail - MGI:1196625 - frizzled class receptor 1

Symbol

Fzd1
Name

frizzled class receptor 1
Synonyms

Fz1, FZ-1

Feature Type

protein coding gene
IDs

MGI:1196625
NCBI Gene: 14362
Gene Overview

MyGene.info: FZD1
Alliance

gene page
Transcription Start Sites

7 TSS

Sequence Map

Chr5:4803839-4808035 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 5, 2.61 cM
Mapping Data

3 experiments

SNPs within 2kb

18 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1196625	protein coding gene	Chr5:4803839-4808216 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0029269	protein coding gene	Chr5:1624434-1628631 (-)
A/J	MGP_AJ_G0029232	protein coding gene	Chr5:1547407-1551603 (-)
AKR/J	MGP_AKRJ_G0029182	protein coding gene	Chr5:1556623-1560819 (-)
BALB/cJ	MGP_BALBcJ_G0029250	protein coding gene	Chr5:1734725-1738922 (-)
C3H/HeJ	MGP_C3HHeJ_G0028970	protein coding gene	Chr5:1741853-1746049 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0029700	protein coding gene	Chr5:1976097-1980293 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026943	protein coding gene	Chr5:1665647-1669836 (-)
CAST/EiJ	MGP_CASTEiJ_G0028383	protein coding gene	Chr5:1711405-1715607 (-)
CBA/J	MGP_CBAJ_G0028931	protein coding gene	Chr5:1922027-1926223 (-)
DBA/2J	MGP_DBA2J_G0029083	protein coding gene	Chr5:1684631-1688827 (-)
FVB/NJ	MGP_FVBNJ_G0029045	protein coding gene	Chr5:1555956-1560152 (-)
LP/J	MGP_LPJ_G0029173	protein coding gene	Chr5:1714731-1718928 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029072	protein coding gene	Chr5:1790924-1795121 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029731	protein coding gene	Chr5:1639217-1643413 (-)
PWK/PhJ	MGP_PWKPhJ_G0028104	protein coding gene	Chr5:1605899-1610094 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027938	protein coding gene	Chr5:1907352-1911554 (-)
WSB/EiJ	MGP_WSBEiJ_G0028463	protein coding gene	Chr5:1648901-1653097 (-)

Human Ortholog

FZD1, frizzled class receptor 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

FZD1, frizzled class receptor 1
Links

HGNC:4038

NCBI Gene ID: 8321

neXtProt AC: NX_Q9UP38

UniProt: Q9UP38
Chr Location

7q21.13; chr7:91264468-91268817 (+) GRCh38.p7

Alliance of Genome Resources

Fzd1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: FZD1
Gene Tree

Fzd1

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Phenotype Summary

19 phenotypes from 4 alleles in 4 genetic backgrounds
17 phenotypes from multigenic genotypes
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

4
Endonuclease-mediated

1
Targeted

3
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mutation of this gene does not appear to result in a phenotype.

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All GO Annotations

57
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1268
Tissues

332
cDNA Data

76
Literature Summary

56

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA FZD1

Xenbase fzd1

ZFIN fzd1

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Fzd1 interacts with 240 markers (Mir1a-1, Mir1a-2, Mir15a, ...) View All

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All Sequences

33
RefSeq

2
UniProt

1
CCDS

CCDS19072.1

Ensembl

ENSMUSG00000044674 (Evidence)
NCBI Gene

14362

			Length	Strain/Species	Flank
genomic	ENSMUSG00000044674	Ensembl Gene Model \| MGI Sequence Detail	4197	C57BL/6J	± kb
transcript	ENSMUST00000054294	Ensembl \| MGI Sequence Detail	4197	Not Applicable
polypeptide	ENSMUSP00000058629	Ensembl \| MGI Sequence Detail	642	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000007718 frizzled-1

(term hierarchy)
InterPro Domains

IPR026550 Frizzled-1/2

IPR036790 Frizzled cysteine-rich domain superfamily

IPR020067 Frizzled domain

IPR015526 Frizzled/secreted frizzled-related protein

IPR000539 Frizzled/Smoothened, transmembrane domain

IPR017981 GPCR, family 2-like

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All nucleic 95

cDNA 77

Primer pair 14

Other 4

Microarray probesets 5

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MGI:2141181

Summaries

All 96

Developmental Gene Expression 56

Gene Ontology 13

Phenotypes 7
Earliest

J:45301 Cygan JA, et al., Novel regulatory interactions revealed by studies of murine limb pattern in Wnt-7a and En-1 mutants. Development. 1997 Dec;124(24):5021-32
Latest

J:298302 Ru J, et al., Malformation of Tear Ducts Underlies the Epiphora and Precocious Eyelid Opening in Prickle 1 Mutant Mice: Genetic Implications for Tear Duct Genesis. Invest Ophthalmol Vis Sci. 2020 Nov 2;61(13):6

TSS for Fzd1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr50014	Chr5:4808026-4808045 (-)	-1 bp
Tssr50013	Chr5:4807999-4808022 (-)	24 bp
Tssr50012	Chr5:4807977-4807995 (-)	49 bp
Tssr50011	Chr5:4807926-4807936 (-)	104 bp
Tssr50010	Chr5:4807908-4807920 (-)	121 bp
Tssr50009	Chr5:4807875-4807887 (-)	154 bp
Tssr50008	Chr5:4807797-4807806 (-)	233 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 09/14/2021 MGI 6.17