About   Help   FAQ
Onecut1 Gene Detail
Summary
  • Symbol
    Onecut1
  • Name
    one cut domain, family member 1
  • Synonyms
    D9Ertd423e, Hfh12, Hnf6, HNF6, Oc1, OC-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196423
    NCBI Gene: 15379
Location & Maps
more
  • Sequence Map
    Chr9:74861921-74891781 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      29861 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 41.93 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    ONECUT1, one cut homeobox 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ONECUT1, one cut homeobox 1
    Orthology source: HomoloGene
  • Synonyms
    HNF6, HNF-6, HNF6A
  • Links
    NCBI Gene ID: 3175
    neXtProt AC: NX_Q9UBC0

  • Chr Location
    15q21.3; chr15:52756963-52790277 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 2 alleles in 4 genetic backgrounds
    5 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Onecut1
Homozygous mutation of this gene results in partial postnatal lethality, billiary tract, pancreas, and islet of Langerhans abnormalities, growth retardation, and glucose and insulin metabolism defects.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034722 VEGA Gene Model | MGI Sequence Detail 29861 C57BL/6J ±  kb
transcript OTTMUST00000088210 VEGA | MGI Sequence Detail 3957 Not Applicable  
polypeptide OTTMUSP00000048065 VEGA | MGI Sequence Detail 465 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    165 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 19
    cDNA 9
    Primer pair 9
    Other 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1261757, MGI:1329018
References
more
  • Summaries
    All 130
    Developmental Gene Expression 89
    Gene Ontology 15
    Phenotypes 29
  • Earliest
    J:46149 Samadani U, et al., The transcriptional activator hepatocyte nuclear factor 6 regulates liver gene expression. Mol Cell Biol. 1996 Nov;16(11):6273-84
  • Latest
    J:226696 Laumonnerie C, et al., Facial whisker pattern is not sufficient to instruct a whisker-related topographic map in the mouse somatosensory brainstem. Development. 2015 Nov 1;142(21):3704-12

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/19/2016
MGI 6.04
The Jackson Laboratory