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Onecut1 Gene Detail
Summary
  • Symbol
    Onecut1
  • Name
    one cut domain, family member 1
  • Synonyms
    D9Ertd423e, Hfh12, Hnf6, HNF6, Oc1, OC-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196423
    NCBI Gene: 15379
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:74861921-74889648 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 41.93 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    158 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196423
protein coding gene Chr9:74861921-74891781 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035031
protein coding gene Chr9:75126391-75156186 (+)
A/J MGP_AJ_G0035012
protein coding gene Chr9:72509202-72539132 (+)
AKR/J MGP_AKRJ_G0034941
protein coding gene Chr9:74251168-74280919 (+)
BALB/cJ MGP_BALBcJ_G0035004
protein coding gene Chr9:72194281-72223931 (+)
C3H/HeJ MGP_C3HHeJ_G0034713
protein coding gene Chr9:74717046-74746762 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035523
protein coding gene Chr9:77125955-77157712 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032434
protein coding gene Chr9:71884157-71913829 (+)
CAST/EiJ MGP_CASTEiJ_G0034035
protein coding gene Chr9:75043178-75074764 (+)
CBA/J MGP_CBAJ_G0034686
protein coding gene Chr9:79781263-79810912 (+)
DBA/2J MGP_DBA2J_G0034845
protein coding gene Chr9:72185513-72215213 (+)
FVB/NJ MGP_FVBNJ_G0034787
protein coding gene Chr9:71486771-71516369 (+)
LP/J MGP_LPJ_G0034926
protein coding gene Chr9:75390117-75419853 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034828
protein coding gene Chr9:80889024-80919299 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035545
protein coding gene Chr9:74409318-74441253 (+)
PWK/PhJ MGP_PWKPhJ_G0033739
protein coding gene Chr9:72460266-72490385 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033572
protein coding gene Chr9:74629229-74658810 (+)
WSB/EiJ MGP_WSBEiJ_G0034147
protein coding gene Chr9:74315687-74345765 (+)



Homology
more
  • Human Ortholog
    ONECUT1, one cut homeobox 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    ONECUT1, one cut homeobox 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HNF6, HNF-6, HNF6A
  • Links
    NCBI Gene ID: 3175
    neXtProt AC: NX_Q9UBC0
    UniProt: Q9UBC0

  • Chr Location
    15q21.3; chr15:52756963-52790264 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    42 phenotypes from 2 alleles in 4 genetic backgrounds
    5 phenotypes from multigenic genotypes
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in partial postnatal lethality, billiary tract, pancreas, and islet of Langerhans abnormalities, growth retardation, and glucose and insulin metabolism defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15379 NCBI Gene Model | MGI Sequence Detail 27728 C57BL/6J ±  kb
    transcript NM_008262 RefSeq | MGI Sequence Detail 1824 C57BL/6  
    polypeptide O08755 UniProt | EBI | MGI Sequence Detail 465 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      cDNA 11
      Primer pair 9
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1261757, MGI:1329018
    References
    more
    • Summaries
      All 153
      Developmental Gene Expression 99
      Gene Ontology 15
      Phenotypes 35
    • Earliest
      J:46149 Samadani U, et al., The transcriptional activator hepatocyte nuclear factor 6 regulates liver gene expression. Mol Cell Biol. 1996 Nov;16(11):6273-84
    • Latest
      J:261641 Schaub JR, et al., De novo formation of the biliary system by TGFbeta-mediated hepatocyte transdifferentiation. Nature. 2018 May;557(7704):247-251

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory