Onecut1 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Onecut1
one cut domain, family member 1
MGI:1196423

52 phenotypes from 2 alleles in 5 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Onecut1^tm1.1Mga/Onecut1^tm1.1Mga Tg(Neurog3-cre)C1Able/0 involves: 129S6/SvEvTac * C57BL/6 * SJL	normal endocrine/exocrine gland phenotype	J:155058
	normal homeostasis/metabolism phenotype	J:155058
Onecut1^tm1.1Mga/Onecut1^tm1.1Mga Tg(Pdx1-cre)89.1Dam/0 involves: 129S6/SvEvTac * C57BL/6 * CBA * SJL	abnormal branching involved in pancreas development	J:155058
	abnormal glucose homeostasis	J:155058
	abnormal pancreas morphology	J:155058
	abnormal pancreas physiology	J:155058
	abnormal pancreatic acinus morphology	J:155058
	abnormal pancreatic duct morphology	J:155058
	abnormal pancreatic primary cilium morphology	J:155058
	absent pancreatic islets	J:155058
	calcified pancreas	J:155058
	decreased pancreatic acinar cell number	J:155058
	decreased pancreatic alpha cell number	J:155058
	decreased pancreatic beta cell number	J:155058
	decreased pancreatic primary cilium number	J:155058
	dilated pancreatic duct	J:155058
	exocrine pancreas atrophy	J:155058
	hemorrhage	J:155058
	increased circulating glucose level	J:155058
	pancreas cyst	J:155058
	pancreas fibrosis	J:155058
	pancreas inflammation	J:155058
	pancreatic acinar-to-ductal metaplasia	J:155058
Onecut1^tm1.1Mga/Onecut1^tm1.1Mga Tg(Six3-cre)69Frty/0 involves: 129S6/SvEvTac * C57BL/6 * DBA/2	abnormal retina outer plexiform layer morphology	J:200752
	decreased a-wave amplitude	J:200752
	decreased b-wave amplitude	J:200752
	disorganized retina outer nuclear layer	J:200752
	retina outer nuclear layer degeneration	J:200752
	thin retina outer nuclear layer	J:200752
	thin retina outer plexiform layer	J:200752
	normal vision/eye phenotype	J:200752
Onecut1^tm1Flem/Onecut1^tm1Flem involves: 129S1/Sv * 129X1/SvJ	abnormal pancreas development	J:83754
	pancreas hypoplasia	J:83754
Onecut1^tm1Flem/Onecut1^tm1Flem involves: 129S1/Sv * 129X1/SvJ * Swiss	abnormal bile duct development	J:75933
	abnormal biliary tract morphology	J:75933
	abnormal endocrine pancreas development	J:121610
	abnormal hepatoblast differentiation	J:100352
	abnormal pancreas development	J:62595, J:121610
	abnormal pancreas morphology	J:121610
	abnormal pancreatic islet morphology	J:62595
	absent gallbladder	J:75933
	absent pancreatic alpha cells	J:121610
	absent pancreatic beta cells	J:121610
	biliary cyst	J:100352
	decreased circulating glucagon level	J:62595
	decreased circulating glucose level	J:62595
	decreased circulating insulin level	J:62595
	decreased pancreatic alpha cell number	J:62595
	decreased pancreatic beta cell number	J:62595
	decreased pancreatic delta cell number	J:62595
	disorganized pancreatic islets	J:62595
	fetal growth retardation	J:62595
	impaired glucose tolerance	J:62595
	increased circulating glucose level	J:62595
	jaundice	J:75933
	pancreas hypoplasia	J:121610
	postnatal growth retardation	J:62595
	postnatal lethality, incomplete penetrance	J:62595

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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