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Nus1 Gene Detail
Summary
  • Symbol
    Nus1
  • Name
    NUS1 dehydrodolichyl diphosphate synthase subunit
  • Synonyms
    1600027K07Rik, D10Ertd438e, MGC:7199, NgBR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196365
    NCBI Gene: 52014
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:52417547-52440183 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 26.64 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    67 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196365
protein coding gene Chr10:52417547-52440192 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017226
protein coding gene Chr10:51577006-51599651 (+)
A/J MGP_AJ_G0017202
protein coding gene Chr10:50060479-50083176 (+)
AKR/J MGP_AKRJ_G0017161
protein coding gene Chr10:51023861-51046494 (+)
BALB/cJ MGP_BALBcJ_G0017163
protein coding gene Chr10:50163035-50185680 (+)
C3H/HeJ MGP_C3HHeJ_G0016985
protein coding gene Chr10:51268951-51291588 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017622
protein coding gene Chr10:53209580-53233503 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015316
protein coding gene Chr10:47280879-47308417 (+)
CAST/EiJ MGP_CASTEiJ_G0016559
protein coding gene Chr10:51394558-51457444 (+)
CBA/J MGP_CBAJ_G0016958
protein coding gene Chr10:55481162-55504489 (+)
DBA/2J MGP_DBA2J_G0017063
protein coding gene Chr10:49472380-49496976 (+)
FVB/NJ MGP_FVBNJ_G0017057
protein coding gene Chr10:48821975-48844620 (+)
LP/J MGP_LPJ_G0017138
protein coding gene Chr10:51656766-51683712 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017086
protein coding gene Chr10:57402973-57426532 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017657
protein coding gene Chr10:50954938-50979071 (+)
PWK/PhJ MGP_PWKPhJ_G0016340
protein coding gene Chr10:49336002-49359759 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016125
protein coding gene Chr10:50569803-50594586 (+)
WSB/EiJ MGP_WSBEiJ_G0016624
protein coding gene Chr10:51180355-51203648 (+)



Homology
more
  • Human Ortholog
    NUS1, NUS1 dehydrodolichyl diphosphate synthase subunit
  • Vertebrate Orthologs
    9
  • Human Ortholog
    NUS1, NUS1 dehydrodolichyl diphosphate synthase subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    C6orf68, CDG1AA, MGC:7199, MRD55, NgBR, TANGO14
  • Links
    NCBI Gene ID: 116150
    neXtProt AC: NX_Q96E22
    UniProt: Q96E22

  • Chr Location
    6q22.1; chr6:117675454-117710727 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human NUS1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 3 alleles in 4 genetic backgrounds
    2 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele die prior to E6.5. MEFs homozygous for a conditionally activated knock-out allele exhibit impaired glycosylation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000023068 Ensembl Gene Model | MGI Sequence Detail 22637 C57BL/6J ±  kb
transcript ENSMUST00000023830 Ensembl | MGI Sequence Detail 4605 Not Applicable  
polypeptide ENSMUSP00000023830 Ensembl | MGI Sequence Detail 297 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000011530 dehydrodolichyl diphosphate synthase complex subunit NUS1
  • EC
  • InterPro Domains
    IPR001441 Decaprenyl diphosphate synthase-like
    IPR036424 Decaprenyl diphosphate synthase-like superfamily
    IPR038887 Dehydrodolichyl diphosphate synthase complex subunit Nus1
Molecular
Reagents
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  • All nucleic 144
    cDNA 143
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
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MGI:1919284, MGI:1933145, MGI:2143731, MGI:2143850
References
more
  • Summaries
    All 44
    Developmental Gene Expression 1
    Gene Ontology 6
    Phenotypes 16
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:243753 Hu W, et al., Nogo-B receptor deficiency increases liver X receptor alpha nuclear translocation and hepatic lipogenesis through an adenosine monophosphate-activated protein kinase alpha-dependent pathway. Hepatology. 2016 Nov;64(5):1559-1576

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
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last database update
06/11/2019
MGI 6.14
The Jackson Laboratory