Fubp1 MGI Mouse Gene Detail - MGI:1196294 - far upstream element (FUSE) binding protein 1

Symbol

Fubp1
Name

far upstream element (FUSE) binding protein 1
Synonyms

9530027K12Rik, FBP, Fubp, Fubp4

Feature Type

protein coding gene
IDs

MGI:1196294
NCBI Gene: 51886
Alliance

gene page
Transcription Start Sites

5 TSS

Sequence Map

Chr3:152210427-152236830 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 77.05 cM
Mapping Data

7 experiments

SNPs within 2kb

169 from dbSNP Build 142
Strain Annotations

18
PCR

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1196294	protein coding gene	Chr3:152210422-152236830 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0027988	protein coding gene	Chr3:156062902-156089231 (+)
A/J	MGP_AJ_G0027947	protein coding gene	Chr3:150403893-150430513 (+)
AKR/J	MGP_AKRJ_G0027913	protein coding gene	Chr3:154362112-154388502 (+)
BALB/cJ	MGP_BALBcJ_G0027959	protein coding gene	Chr3:150240748-150267162 (+)
C3H/HeJ	MGP_C3HHeJ_G0027689	protein coding gene	Chr3:154806535-154832981 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0028402	protein coding gene	Chr3:161208450-161235919 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025740	protein coding gene	Chr3:145239440-145266613 (+)
CAST/EiJ	MGP_CASTEiJ_G0027142	protein coding gene	Chr3:154882108-154908418 (+)
CBA/J	MGP_CBAJ_G0027664	protein coding gene	Chr3:166992371-167018681 (+)
DBA/2J	MGP_DBA2J_G0027804	protein coding gene	Chr3:149509818-149536235 (+)
FVB/NJ	MGP_FVBNJ_G0027771	protein coding gene	Chr3:146886766-146913129 (+)
LP/J	MGP_LPJ_G0027915	protein coding gene	Chr3:157438803-157465087 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027804	protein coding gene	Chr3:175522995-175550611 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028461	protein coding gene	Chr3:154056887-154083289 (+)
PWK/PhJ	MGP_PWKPhJ_G0026865	protein coding gene	Chr3:149395291-149422118 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0026693	protein coding gene	Chr3:152216442-152242642 (+)
WSB/EiJ	MGP_WSBEiJ_G0027222	protein coding gene	Chr3:155065872-155092406 (+)

Human Ortholog

FUBP1, far upstream element binding protein 1

Vertebrate Orthologs

9

Human Ortholog

FUBP1, far upstream element binding protein 1
Orthology source: HomoloGene, HGNC
Synonyms

FBP, FUBP, hDH V
Links

HGNC:4004

NCBI Gene ID: 8880

neXtProt AC: NX_Q96AE4

UniProt: Q96AE4
Chr Location

1p31.1; chr1:77944055-77979494 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 48253
1 human;1 mouse;1 rat;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: FUBP1
Gene Tree

Fubp1

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Phenotype Summary

33 phenotypes from 1 allele in 1 genetic background
11 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

70
Endonuclease-mediated

1
Gene trapped

67
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

46 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a null allele exhibit pre- and perinatal lethality, cerebral hyperplasia, pale liver, hypoplastic lungs, spleen, thymus and bone marrow, cardiac hypertrophy, placental distress, small size, and anemia associated with variable, multilineage hematopoietic deficiency.

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All GO Annotations

18
GO References

8

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

97
Tissues

76
cDNA Data

312
Literature Summary

12

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase fubp1

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Fubp1 interacts with 496 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

135
RefSeq

43
UniProt

14
CCDS

CCDS38672.1
UniGene

278922

Ensembl

ENSMUSG00000028034 (Evidence)
NCBI Gene

51886

			Length	Strain/Species	Flank
genomic	51886	NCBI Gene Model \| MGI Sequence Detail	26404	C57BL/6J	± kb
transcript	NM_001355369	RefSeq \| MGI Sequence Detail	6670	C57BL/6
polypeptide	Q91WJ8	UniProt \| EBI \| MGI Sequence Detail	651	Not Applicable

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UniProt

14 Sequences
PDB

1X4M, 1X4N
InterPro Domains

IPR015096 Far upstream element-binding protein, C-terminal

IPR004087 K Homology domain

IPR004088 K Homology domain, type 1

IPR036612 K Homology domain, type 1 superfamily

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All nucleic 317

Genomic 1

cDNA 312

Primer pair 4

Microarray probesets 5

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MGI:1336165, MGI:1924642

Summaries

All 52

Developmental Gene Expression 12

Gene Ontology 8

Phenotypes 11
Earliest

J:40384 Craig JC, et al., Developmental expression of morphoregulatory genes in the mouse embryo: an analytical approach using a novel technology. Biochem Mol Med. 1997 Apr;60(2):81-91
Latest

J:229985 Zhou W, et al., Far Upstream Element Binding Protein Plays a Crucial Role in Embryonic Development, Hematopoiesis, and Stabilizing Myc Expression Levels. Am J Pathol. 2016 Mar;186(3):701-15

TSS for Fubp1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr32396	Chr3:152209899-152209928 (+)	-513 bp
Tssr32397	Chr3:152210454-152210465 (+)	33 bp
Tssr32398	Chr3:152210469-152210534 (+)	75 bp
Tssr32401	Chr3:152226143-152226162 (+)	15,726 bp
Tssr32403	Chr3:152234794-152234800 (+)	24,370 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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