Fubp1 MGI Mouse Gene Detail - MGI:1196294 - far upstream element (FUSE) binding protein 1

Fubp1 Gene Detail

Symbol

Fubp1
Name

far upstream element (FUSE) binding protein 1
Synonyms

9530027K12Rik, FBP, Fubp, Fubp4

Feature Type

protein coding gene
IDs

MGI:1196294
NCBI Gene: 51886

Sequence Map

Chr3:152210422-152236826 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

26405 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 77.05 cM
Mapping Data

7 experiments

Human Ortholog

FUBP1, far upstream element binding protein 1

Vertebrate Orthologs

9

Human Ortholog

FUBP1, far upstream element binding protein 1
Orthology source: HomoloGene, HGNC
Synonyms

FBP, FUBP, hDH V
Links

HGNC:4004

NCBI Gene ID: 8880

neXtProt AC: NX_Q96AE4

UniProt: Q96AE4
Chr Location

1p31.1; chr1:77944055-77979494 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 48253
1 human;1 mouse;1 rat;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: FUBP1
Gene Tree

Fubp1

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Phenotype Summary

33 phenotypes from 1 allele in 1 genetic background
10 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

69
Gene trapped

67
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

46 strains or lines available

Mice homozygous for a null allele exhibit pre- and perinatal lethality, cerebral hyperplasia, pale liver, hypoplastic lungs, spleen, thymus and bone marrow, cardiac hypertrophy, placental distress, small size, and anemia associated with variable, multilineage hematopoietic deficiency.

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All GO Annotations

14
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

97
Tissues

76
cDNA Data

310
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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Fubp1 interacts with 496 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

150
RefSeq

43
UniProt

14
CCDS

CCDS38672.1
UniGene

278922

			Length	Strain/Species	Flank
genomic	OTTMUSG00000053719	VEGA Gene Model \| MGI Sequence Detail	26405	C57BL/6J	± kb
transcript	OTTMUST00000133762	VEGA \| MGI Sequence Detail	4846	Not Applicable
polypeptide	OTTMUSP00000071043	VEGA \| MGI Sequence Detail	700	Not Applicable

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SNPs within 2kb

168 from dbSNP Build 142

PCR

1

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UniProt

14 Sequences
Protein Ontology

PR:000007695 far upstream element-binding protein 1

(term hierarchy)
PDB

1X4M, 1X4N
InterPro Domains

IPR015096 Far upstream element-binding protein, C-terminal

IPR004087 K Homology domain

IPR015946 K homology domain-like, alpha/beta

IPR004088 K Homology domain, type 1

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All nucleic 315

Genomic 1

cDNA 310

Primer pair 4

Microarray probesets 5

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MGI:1336165, MGI:1924642

Summaries

All 50

Developmental Gene Expression 12

Gene Ontology 6

Phenotypes 10
Earliest

J:40384 Craig JC, et al., Developmental expression of morphoregulatory genes in the mouse embryo: an analytical approach using a novel technology. Biochem Mol Med. 1997 Apr;60(2):81-91
Latest

J:229985 Zhou W, et al., Far Upstream Element Binding Protein Plays a Crucial Role in Embryonic Development, Hematopoiesis, and Stabilizing Myc Expression Levels. Am J Pathol. 2016 Mar;186(3):701-15

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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