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Tnfsf12 Gene Detail
Summary
  • Symbol
    Tnfsf12
  • Name
    tumor necrosis factor (ligand) superfamily, member 12
  • Synonyms
    APO3L, DR3L, Tweak
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196259
    NCBI Gene: 21944
  • Gene Overview
    MyGene.info: TNFSF12
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69686250-69695849 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.86 cM, cytoband B4
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    72 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196259
protein coding gene Chr11:69686240-69696098 (-)
129S1/SvImJ MGP_129S1SvImJ_G0018550
protein coding gene Chr11:70145262-70155097 (-)
A/J MGP_AJ_G0018518
protein coding gene Chr11:67503199-67512767 (-)
AKR/J MGP_AKRJ_G0018487
protein coding gene Chr11:69512943-69524360 (-)
BALB/cJ MGP_BALBcJ_G0018490
protein coding gene Chr11:67812625-67822599 (-)
C3H/HeJ MGP_C3HHeJ_G0018303
protein coding gene Chr11:69544728-69556287 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018941
protein coding gene Chr11:72266316-72278806 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0016586
protein coding gene Chr11:64422038-64431148 (-)
CAST/EiJ MGP_CASTEiJ_G0017858
protein coding gene Chr11:69786029-69797345 (-)
CBA/J MGP_CBAJ_G0018276
protein coding gene Chr11:75502674-75513506 (-)
DBA/2J MGP_DBA2J_G0018385
protein coding gene Chr11:67085665-67097038 (-)
FVB/NJ MGP_FVBNJ_G0018375
protein coding gene Chr11:66728972-66739425 (-)
LP/J MGP_LPJ_G0018455
protein coding gene Chr11:70713825-70723342 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0018398
protein coding gene Chr11:76093218-76104902 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018983
protein coding gene Chr11:69774569-69785553 (-)
PWK/PhJ MGP_PWKPhJ_G0017632
protein coding gene Chr11:67735545-67745484 (-)
SPRET/EiJ MGP_SPRETEiJ_G0017422
protein coding gene Chr11:69594511-69604036 (-)
WSB/EiJ MGP_WSBEiJ_G0017912
protein coding gene Chr11:69446870-69458155 (-)



Homology
more
  • Human Ortholog
    TNFSF12, TNF superfamily member 12
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TNFSF12, TNF superfamily member 12
    Orthology source: HomoloGene, HGNC
  • Synonyms
    APO3L, DR3LG, TNLG4A, TWEAK
  • Links
    NCBI Gene ID: 8742
    neXtProt AC: NX_O43508
    UniProt: O43508

  • Chr Location
    17p13.1; chr17:7549058-7557890 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    34 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have increased numbers of natural killer cells, particulalry in secondary lymph organs. They display an enhanced inflammatory response, increased susceptibility to lipopolysaccharide, and increased tumor resistance.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000097328 Ensembl Gene Model | MGI Sequence Detail 9600 C57BL/6J ±  kb
    transcript ENSMUST00000181810 Ensembl | MGI Sequence Detail 1435 Not Applicable  
    polypeptide ENSMUSP00000137972 Ensembl | MGI Sequence Detail 249 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 10
      cDNA 10

      Microarray probesets 2
    References
    more
    • Summaries
      All 94
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 34
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:261428 Martin-Sanchez D, et al., TWEAK and RIPK1 mediate a second wave of cell death during AKI. Proc Natl Acad Sci U S A. 2018 Apr 17;115(16):4182-4187

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory