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Tnfsf12 Gene Detail
Summary
  • Symbol
    Tnfsf12
  • Name
    tumor necrosis factor (ligand) superfamily, member 12
  • Synonyms
    APO3L, DR3L, Tweak
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196259
    NCBI Gene: 21944
  • Gene Overview
    MyGene.info: TNFSF12
Location & Maps
more
  • Sequence Map
    Chr11:69686250-69695849 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9600 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 42.86 cM, cytoband B4
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    TNFSF12, tumor necrosis factor superfamily member 12
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TNFSF12, tumor necrosis factor superfamily member 12
    Orthology source: HomoloGene
  • Synonyms
    APO3L, DR3LG, TNLG4A, TWEAK
  • Links
    NCBI Gene ID: 8742
    neXtProt AC: NX_O43508

  • Chr Location
    17p13; chr17:7549058-7557890 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 2 alleles in 2 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    8
  • Transgenic
    1
  • Genomic Mutations
    2 involving Tnfsf12
  • Incidental Mutations
    APF
Mice homozygous for disruptions in this gene have increased numbers of natural killer cells, particulalry in secondary lymph organs. They display an enhanced inflammatory response, increased susceptibility to lipopolysaccharide, and increased tumor resistance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005999 VEGA Gene Model | MGI Sequence Detail 9600 C57BL/6J ±  kb
transcript OTTMUST00000013428 VEGA | MGI Sequence Detail 1435 Not Applicable  
polypeptide OTTMUSP00000006216 VEGA | MGI Sequence Detail 249 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    72 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000016487 tumor necrosis factor ligand superfamily member 12
  • InterPro Domains
    IPR006052 Tumour necrosis factor domain
    IPR008983 Tumour necrosis factor-like domain
Molecular
Reagents
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  • All nucleic 10
    cDNA 9
    Other 1

    Microarray probesets 2
References
more
  • Summaries
    All 63
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 31
  • Earliest
    J:44733 Chicheportiche Y, et al., TWEAK, a new secreted ligand in the tumor necrosis factor family that weakly induces apoptosis. J Biol Chem. 1997 Dec 19;272(51):32401-10
  • Latest
    J:221345 Bowerman M, et al., Tweak regulates astrogliosis, microgliosis and skeletal muscle atrophy in a mouse model of amyotrophic lateral sclerosis. Hum Mol Genet. 2015 Jun 15;24(12):3440-56

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory