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Cdk8 Gene Detail
Summary
  • Symbol
    Cdk8
  • Name
    cyclin dependent kinase 8
  • Synonyms
    MGC:37111
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196224
    NCBI Gene: 264064
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:146168040-146239684 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 5, 85.19 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    286 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1196224
protein coding gene Chr5:146167432-146239684 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030375
protein coding gene Chr5:151794415-151867814 (+)
A/J MGP_AJ_G0030348
protein coding gene Chr5:145380672-145456347 (+)
AKR/J MGP_AKRJ_G0030275
protein coding gene Chr5:149804895-149883046 (+)
BALB/cJ MGP_BALBcJ_G0030357
protein coding gene Chr5:146589557-146664183 (+)
C3H/HeJ MGP_C3HHeJ_G0030071
protein coding gene Chr5:150757517-150835524 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030812
protein coding gene Chr5:157370045-157444030 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028025
protein coding gene Chr5:139799439-139873362 (+)
CAST/EiJ MGP_CASTEiJ_G0029473
protein coding gene Chr5:150263693-150340219 (+)
CBA/J MGP_CBAJ_G0030049
protein coding gene Chr5:163899310-163980845 (+)
DBA/2J MGP_DBA2J_G0030193
protein coding gene Chr5:145042042-145116118 (+)
FVB/NJ MGP_FVBNJ_G0030147
protein coding gene Chr5:144254449-144325617 (+)
LP/J MGP_LPJ_G0030280
protein coding gene Chr5:152474812-152547164 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030183
protein coding gene Chr5:166261513-166335882 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030842
protein coding gene Chr5:149723529-149795629 (+)
PWK/PhJ MGP_PWKPhJ_G0029187
protein coding gene Chr5:144129037-144202795 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029023
protein coding gene Chr5:146973902-147054865 (+)
WSB/EiJ MGP_WSBEiJ_G0029550
protein coding gene Chr5:150527802-150607276 (+)



Homology
more
  • Human Ortholog
    CDK8, cyclin dependent kinase 8
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CDK8, cyclin dependent kinase 8
  • Synonyms
    IDDHBA, K35
  • Links
    NCBI Gene ID: 1024
    neXtProt AC: NX_P49336
    UniProt: P49336

  • Chr Location
    13q12.13; chr13:26254104-26420982 (+)  GRCh38

Human Diseases
more
  • Diseases
    1 with human CDK8 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 3 alleles in 4 genetic backgrounds
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene-trapped allele die prior to implantation exhibiting fragmented blastomeres and failure to undergo compaction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029635 Ensembl Gene Model | MGI Sequence Detail 71645 C57BL/6J ±  kb
    transcript ENSMUST00000031640 Ensembl | MGI Sequence Detail 2973 Not Applicable  
    polypeptide ENSMUSP00000031640 Ensembl | MGI Sequence Detail 464 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 94
      cDNA 93
      Primer pair 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 5
      Gene Ontology 11
      Phenotypes 24
    • Earliest
      J:45218 Ahuja HS, et al., Association of cyclin-dependent kinase 5 and its activator p35 with apoptotic cell death. Dev Genet. 1997;21(4):258-67
    • Latest
      J:341371 Prieto S, et al., CDK8 and CDK19 act redundantly to control the CFTR pathway in the intestinal epithelium. EMBO Rep. 2023 Feb 6;24(2):e54261

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory