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Cdk8 Gene Detail
Summary
  • Symbol
    Cdk8
  • Name
    cyclin-dependent kinase 8
  • Synonyms
    MGC:37111
  • Feature Type
    protein coding gene
  • IDs
    MGI:1196224
    NCBI Gene: 264064
  • Gene Overview
    MyGene.info: CDK8
Location & Maps
more
  • Sequence Map
    Chr5:146231230-146302874 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      71645 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 85.19 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    CDK8, cyclin dependent kinase 8
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CDK8, cyclin dependent kinase 8
    Orthology source: HomoloGene, HGNC
  • Synonyms
    K35
  • Links
    NCBI Gene ID: 1024
    neXtProt AC: NX_P49336

  • Chr Location
    13q12.13; chr13:26254125-26405238 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    29
  • Gene trapped
    25
  • Targeted
    4
  • Incidental Mutations
Mice homozygous for a gene-trapped allele die prior to implantation exhibiting fragmented blastomeres and failure to undergo compaction.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025856 VEGA Gene Model | MGI Sequence Detail 71645 C57BL/6J ±  kb
transcript OTTMUST00000063710 VEGA | MGI Sequence Detail 2973 Not Applicable  
polypeptide OTTMUSP00000031548 VEGA | MGI Sequence Detail 464 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    288 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 94
    cDNA 92
    Primer pair 1
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 43
    Developmental Gene Expression 3
    Gene Ontology 8
    Phenotypes 13
  • Earliest
    J:45218 Ahuja HS, et al., Association of cyclin-dependent kinase 5 and its activator p35 with apoptotic cell death. Dev Genet. 1997;21(4):258-67
  • Latest
    J:233814 Feng D, et al., mTORC1 Down-Regulates Cyclin-Dependent Kinase 8 (CDK8) and Cyclin C (CycC). PLoS One. 2015;10(6):e0126240

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory