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Cdk8
Gene Detail
Symbol

Name
ID
Cdk8
cyclin-dependent kinase 8
MGI:1196224
Synonyms
MGC:37111
Feature Type
protein coding gene
Genetic Map
Chromosome 5
85.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr5:146231230-146302874 bp, + strand
From VEGA annotation of GRCm38

  71645 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55565  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdk8

Human
homologs
Human Homolog CDK8, cyclin-dependent kinase 8
NCBI Gene ID 1024
neXtProt AC  NX_P49336
Human Synonyms  K35
Human Chr (Location)  13q12; chr13:26254125-26405238 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(29) : Gene trapped(26) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a gene-trapped allele die prior to implantation exhibiting fragmented blastomeres and failure to undergo compaction.
 
Interactions
Cdk8 interacts with 407 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (18 annotations)
Process phosphorylation, protein phosphorylation, ...
Component mediator complex, nucleus
Function ATP binding, cyclin-dependent protein serine/threonine kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (1)    Tissues (1)    Tissue x Stage Matrix (view)
Assay TypeResults
In situ reporter (knock in) 1
cDNA source data(91)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(93) cDNA(91) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000025856 (Evidence)
Ensembl Gene ModelENSMUSG00000029635 (Evidence)
Entrez Gene264064 (Evidence)
UniGene260576
DFCITC1639432, TC1637730, TC1603330, TC1578979
DoTSDT.110698035, DT.101717503, DT.110698058, DT.535542
NIA Mouse Gene IndexU094921, U006436
EC2.7.11.23, 2.7.11.22
Consensus CDS ProjectCCDS19869.1
International Mouse Knockout Project StatusCdk8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025856 VEGA Gene Model | MGI Sequence Detail 71645 C57BL/6J ±  kb
transcript OTTMUST00000063710 VEGA | MGI Sequence Detail 2973 Not Applicable 
polypeptide OTTMUSP00000031548 VEGA | MGI Sequence Detail 464 Not Applicable 

For the selected sequences
All sequences(76) RefSeq(15) UniProt(11)
Polymorphisms
SNPs within 2kb(287 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
Protein Ontology PR:000005266 cyclin-dependent kinase 8
References
(Earliest) J:45218 Ahuja HS, et al., Association of cyclin-dependent kinase 5 and its activator p35 with apoptotic cell death. Dev Genet. 1997;21(4):258-67
(Latest) J:188596 Porter DC, et al., Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13799-804
All references(44)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory