Cdk8
Gene Detail

Symbol Name ID

Cdk8 cyclin-dependent kinase 8 MGI:1196224

Synonyms

MGC:37111

Feature Type

protein coding gene

Genetic Map

Chromosome 5

85.19 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr5:146231230-146302874 bp, + strand From VEGA annotation of GRCm38   71645 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55565  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Cdk8

Human homologs

Human Homolog		CDK8, cyclin-dependent kinase 8
NCBI Gene ID		1024
neXtProt AC		NX_P49336
Human Synonyms		K35
Human Chr (Location)		13q12; chr13:26828756-26978569 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(26) : Targeted(2) Gene trapped(24)
 

Mice homozygous for a gene-trapped allele die prior to implantation exhibiting fragmented blastomeres and failure to undergo compaction.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	phosphorylation, protein phosphorylation, ...
Component	mediator complex, nucleus
Function	ATP binding, cyclin-dependent protein serine/threonine kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (1)    Tissues (1)   
Theiler Stages: 19

Assay Type	Results
In situ reporter (knock in)	1

cDNA source data(94)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(96) cDNA(94) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000025856 (Evidence)
Ensembl Gene Model	ENSMUSG00000029635 (Evidence)
Entrez Gene	264064 (Evidence)
UniGene	260576
DFCI	TC1578979, TC1603330, TC1637730, TC1639432
DoTS	DT.101717503, DT.110698035, DT.110698058, DT.535542
NIA Mouse Gene Index	U006436, U094921
EC	2.7.11.22, 2.7.11.23
Consensus CDS Project	CCDS19869.1
International Mouse Knockout Project Status	Cdk8

Sequences

Length	Strain/Species
genomic	OTTMUSG00000025856	VEGA Gene Model | MGI Sequence Detail	71645	C57BL/6J
transcript	OTTMUST00000063710	VEGA | MGI Sequence Detail	2973	Not Applicable
polypeptide	OTTMUSP00000031548	VEGA | MGI Sequence Detail	464	Not Applicable

All sequences(59) RefSeq(3) UniProt(6)

Polymorphisms

SNPs(259 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual-specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
Protein Ontology	PR:000005266	cyclin-dependent kinase 8

References

(Earliest) J:45218 Ahuja HS, et al., Association of cyclin-dependent kinase 5 and its activator p35 with apoptotic cell death. Dev Genet. 1997;21(4):258-67
(Latest) J:188596 Porter DC, et al., Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13799-804
All references(41)