Ctnnd2 MGI Mouse Gene Detail - MGI:1195966 - catenin delta 2

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Ctnnd2 Gene Detail

Symbol

Ctnnd2
Name

catenin delta 2
Synonyms

catenin (cadherin associated protein), delta 2, Catnd2, neurojugin, Nprap

Feature Type

protein coding gene
IDs

MGI:1195966
NCBI Gene: 18163
Alliance

gene page
Transcription Start Sites

29 TSS

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Sequence Map

Chr15:30172739-31029487 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 12.02 cM
Mapping Data

1 experiment

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SNPs within 2kb

10382 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_1195966	protein coding gene	Chr15:30172680-31029490 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021761	protein coding gene	Chr15:28375212-29251789 (+)
A/J	MGP_AJ_G0021721	protein coding gene	Chr15:27229468-28073769 (+)
AKR/J	MGP_AKRJ_G0021699	protein coding gene	Chr15:27921815-28789936 (+)
BALB/cJ	MGP_BALBcJ_G0021728	protein coding gene	Chr15:27241742-28081786 (+)
C3H/HeJ	MGP_C3HHeJ_G0021503	protein coding gene	Chr15:27950966-28815073 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022167	protein coding gene	Chr15:29510957-30417850 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019706	protein coding gene	Chr15:25405836-26198775 (+)
CAST/EiJ	MGP_CASTEiJ_G0021019	protein coding gene	Chr15:28444666-29319601 (+)
CBA/J	MGP_CBAJ_G0021472	protein coding gene	Chr15:30361869-31290435 (+)
DBA/2J	MGP_DBA2J_G0021596	protein coding gene	Chr15:26978955-27825853 (+)
FVB/NJ	MGP_FVBNJ_G0021574	protein coding gene	Chr15:26556744-27399803 (+)
LP/J	MGP_LPJ_G0021665	protein coding gene	Chr15:28246191-29123420 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021599	protein coding gene	Chr15:33313738-34261667 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022190	protein coding gene	Chr15:28148220-29027427 (+)
PWK/PhJ	MGP_PWKPhJ_G0020763	protein coding gene	Chr15:27201322-28056760 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020601	protein coding gene	Chr15:27951192-28829447 (+)
WSB/EiJ	MGP_WSBEiJ_G0021075	protein coding gene	Chr15:28107723-28991662 (+)

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Human Ortholog

CTNND2, catenin delta 2

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CTNND2, catenin delta 2
Synonyms

GT24, NPRAP
Links

HGNC:2516

NCBI Gene ID: 1501

neXtProt AC: NX_Q9UQB3

UniProt: Q9UQB3
Chr Location

5p15.2; chr5:10971836-11904446 (-) GRCh38

MGI Vertebrate Homology

Ctnnd2 stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: CTNND2
Gene Tree

Ctnnd2

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Diseases

3 with human CTNND2 associations

				Human Disease	Mouse Models
				anxiety disorder IDs anxiety disorder DOID:2030 DOID:12884 ICD10CM:F41.9 ICD9CM:300.09 MESH:D001008 NCI:C2878 OMIM:607834 UMLS_CUI:C0003469
				major depressive disorder IDs major depressive disorder DOID:1470 DOID:10614 DOID:2240 DOID:2241 DOID:7580 EFO:0003761 ICD10CM:F32 ICD10CM:F33.9 ICD9CM:296.2 ICD9CM:296.20 ICD9CM:296.3 ICD9CM:296.30 NCI:C34796 OMIM:608520 OMIM:608691 UMLS_CUI:C0024517 UMLS_CUI:C0154409
				schizophrenia IDs schizophrenia DOID:5419 DOID:14734 ICD10CM:F20 ICD9CM:295 ICD9CM:295.8 ICD9CM:295.80 ICD9CM:295.9 ICD9CM:295.90 MESH:D012559 NCI:C3362 OMIM:181500 UMLS_CUI:C0036341

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

5 phenotypes from 1 allele in 1 genetic background
19 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

2
Endonuclease-mediated

5
Targeted

1
Genomic Mutations

2 involving Ctnnd2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

65 strains or lines available

Mice homozygous for a reporter allele exhibit abnormal conditioning, spatial learning and coordination behaviors and abnormal long term potentiation.

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All GO Annotations

25
GO References

10

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

801
Tissues

48
cDNA Data

78
Literature Summary

11

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase ctnnd2

ZFIN ctnnd2a, ctnnd2b

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All Sequences

75
RefSeq

12
UniProt

10
CCDS

CCDS27405.1, CCDS88745.1

Ensembl

ENSMUSG00000022240 (Evidence)
NCBI Gene

18163

Representative Sequences				Length	Strain/Species	Flank
	genomic	ENSMUSG00000022240	Ensembl Gene Model \| MGI Sequence Detail	856749	C57BL/6J	± kb
	transcript	ENSMUST00000081728	Ensembl \| MGI Sequence Detail	5944	Not Applicable
	polypeptide	ENSMUSP00000080427	Ensembl \| MGI Sequence Detail	1246	Not Applicable

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UniProt

10 Sequences
Protein Ontology

PR:000006013 catenin delta-2

(term hierarchy)
InterPro Domains

IPR000225 Armadillo

IPR011989 Armadillo-like helical

IPR016024 Armadillo-type fold

IPR028435 Plakophilin/Delta catenin

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All nucleic 81

cDNA 79

Primer pair 2

Microarray probesets 4

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Summaries

All 60

Developmental Gene Expression 11

Gene Ontology 10

Phenotypes 19
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:342969 Mendez-Vazquez H, et al., The autism-associated loss of delta-catenin functions disrupts social behavior. Proc Natl Acad Sci U S A. 2023 May 30;120(22):e2300773120

TSS for Ctnnd2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr130913	Chr15:30172665-30172713 (+)	-50 bp
Tssr130914	Chr15:30172716-30172746 (+)	-8 bp
Tssr130915	Chr15:30172800-30172811 (+)	67 bp
Tssr130916	Chr15:30172824-30172877 (+)	112 bp
Tssr130917	Chr15:30172887-30172914 (+)	162 bp
Tssr130924	Chr15:30303597-30303600 (+)	130,860 bp
Tssr130925	Chr15:30333353-30333360 (+)	160,618 bp
Tssr130926	Chr15:30333977-30333994 (+)	161,247 bp
Tssr130927	Chr15:30338601-30338604 (+)	165,864 bp
Tssr130928	Chr15:30457737-30457745 (+)	285,002 bp
Tssr130929	Chr15:30457773-30457856 (+)	285,076 bp
Tssr130930	Chr15:30457997-30458014 (+)	285,267 bp
Tssr130931	Chr15:30486009-30486026 (+)	313,279 bp
Tssr130935	Chr15:30539729-30539742 (+)	366,997 bp
Tssr130936	Chr15:30633128-30633131 (+)	460,391 bp
Tssr130937	Chr15:30634839-30634855 (+)	462,108 bp
Tssr130938	Chr15:30634889-30634902 (+)	462,157 bp
Tssr130939	Chr15:30646381-30646383 (+)	473,643 bp
Tssr130940	Chr15:30646660-30646718 (+)	473,950 bp
Tssr130941	Chr15:30646728-30646745 (+)	473,998 bp
Tssr130942	Chr15:30646813-30646832 (+)	474,084 bp
Tssr130943	Chr15:30646849-30646862 (+)	474,117 bp
Tssr130944	Chr15:30646879-30646921 (+)	474,161 bp
Tssr130945	Chr15:30646993-30647057 (+)	474,286 bp
Tssr130946	Chr15:30647082-30647102 (+)	474,353 bp
Tssr130947	Chr15:30647154-30647230 (+)	474,453 bp
Tssr130948	Chr15:30730351-30730357 (+)	557,615 bp
Tssr130949	Chr15:31004918-31004944 (+)	832,192 bp
Tssr130950	Chr15:31027920-31027926 (+)	855,184 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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