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Ilk
Gene Detail
Symbol

Name
ID
Ilk
integrin linked kinase
MGI:1195267
Synonyms
ESTM24
Feature Type
protein coding gene
Genetic Map
Chromosome 7
55.97 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:105736592-105742925 bp, + strand
From VEGA annotation of GRCm38

  6334 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3318  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: ILK
Protein SuperFamily: integrin-linked protein kinase
Gene Tree: Ilk

Human
homologs
ILK, integrin-linked kinase
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3611
neXtProt AC: NX_Q13418

Human Synonyms: HEL-S-28, ILK-1, ILK-2, P59, p59ILK

Human Chr (Location): 11p15.4; chr11:6603708-6610874 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(17) : Gene trapped(2) Targeted(15)
Incidental mutations (data from CvDC )
Phenotype Images(1)
Interactions
Ilk interacts with 47 markers (Mir30c-1, Mir30c-2, Mir31, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (90 annotations)
Process branching involved in ureteric bud morphogenesis, cell aging, ...
Component axon, cell-cell junction, ...
Function ATP binding, integrin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (24 records)
Data Summary: Results (68)    Tissues (60)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 15
RT-PCR 46
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ilk ; ZFIN ilk    NEW 
Molecular
reagents
All nucleic(13) cDNA(11) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000025598 (Evidence)
Ensembl Gene Model ENSMUSG00000030890 (Evidence)
Entrez Gene 16202 (Evidence)
EC 2.7.11.1
Consensus CDS Project CCDS21659.1
International Mouse Phenotyping Consortium Status Ilk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025598 VEGA Gene Model | MGI Sequence Detail 6334 C57BL/6J ±  kb
transcript OTTMUST00000062972 VEGA | MGI Sequence Detail 1795 Not Applicable 
polypeptide OTTMUSP00000031102 VEGA | MGI Sequence Detail 452 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(8) UniProt(3)
Polymorphisms
SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology PR:000009009 integrin-linked protein kinase
References
(Earliest) J:43595 Li F, et al., Identification and characterization of a mouse protein kinase that is highly homologous to human integrin-linked kinase. Biochim Biophys Acta. 1997 Oct 11;1358(3):215-20
(Latest) J:218617 Vi L, et al., Modulation of Type II TGF-beta Receptor Degradation by Integrin-Linked Kinase. J Invest Dermatol. 2015 Mar;135(3):885-94
All references(112)
Other
accession IDs
MGI:1201384

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory