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Ilk Gene Detail
Summary
  • Symbol
    Ilk
  • Name
    integrin linked kinase
  • Synonyms
    ESTM24
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195267
    NCBI Gene: 16202
  • Gene Overview
    MyGene.info: ILK
Location & Maps
more
  • Sequence Map
    Chr7:105736592-105742925 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6334 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 55.97 cM, cytoband E1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    ILK, integrin linked kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    ILK, integrin linked kinase
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL-S-28, ILK-1, ILK-2, P59, p59ILK
  • Links
    NCBI Gene ID: 3611
    neXtProt AC: NX_Q13418

  • Chr Location
    11p15.4; chr11:6603708-6610874 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    100 phenotypes from 12 alleles in 8 genetic backgrounds
    4 phenotypes from multigenic genotypes
    1 images
    70 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    19
  • Chemically induced (other)
    1
  • Gene trapped
    2
  • Radiation induced
    1
  • Targeted
    15
  • Genomic Mutations
    2 involving Ilk
  • Incidental Mutations
Nullizygous embryos do not polarize the epiblast and die after implantation. Mice with mutations in the ATP-binding site show aphagia, hunched posture, and neonatal death due to renal aplasia. Mice with mutations in the paxillin-binding site show vasculogenesis and growth defects, and die at ~E12.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025598 VEGA Gene Model | MGI Sequence Detail 6334 C57BL/6J ±  kb
transcript OTTMUST00000062972 VEGA | MGI Sequence Detail 1795 Not Applicable  
polypeptide OTTMUSP00000031102 VEGA | MGI Sequence Detail 452 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    38 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 13
    cDNA 11
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGI:1201384
References
more
  • Summaries
    All 123
    Developmental Gene Expression 27
    Gene Ontology 22
    Phenotypes 70
  • Earliest
    J:43595 Li F, et al., Identification and characterization of a mouse protein kinase that is highly homologous to human integrin-linked kinase. Biochim Biophys Acta. 1997 Oct 11;1358(3):215-20
  • Latest
    J:231630 Krenn PW, et al., ILK Induction in Lymphoid Organs by a TNFalpha-NF-kappaB-Regulated Pathway Promotes the Development of Chronic Lymphocytic Leukemia. Cancer Res. 2016 Apr 15;76(8):2186-96

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory