About   Help   FAQ
Ilk
Gene Detail
Symbol

Name
ID
Ilk
integrin linked kinase
MGI:1195267
Synonyms
ESTM24
Feature Type
protein coding gene
Genetic Map
Chromosome 7
55.97 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:105736592-105742925 bp, + strand
From VEGA annotation of GRCm38

  6334 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3318  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: integrin-linked protein kinase
Gene Tree: Ilk

Human
homologs
Human Homolog ILK, integrin-linked kinase
NCBI Gene ID 3611
neXtProt AC  NX_Q13418
Human Synonyms  HEL-S-28, ILK-1, ILK-2, P59, p59ILK
Human Chr (Location)  11p15.4; chr11:6603708-6610874 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(2) Targeted(14)
 
Homozygous disruptions of this gene result in embryonic lethality. Homozygous mutant embryos fail to form a mature epiblast and die around time of implantation. Conditional deletion targeted specifically to chondrocytes lead to reduced cell proliferation, dwarfism, and shortened limbs.
 
Interactions
Ilk interacts with 47 markers (Mir30c-1, Mir30c-2, Mir31, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (92 annotations)
Process branching involved in ureteric bud morphogenesis, cell aging, ...
Component axon, cell-cell junction, ...
Function ATP binding, integrin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (68)    Tissues (60)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 15
RT-PCR 46
cDNA source data(9)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(11) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000025598 (Evidence)
Ensembl Gene ModelENSMUSG00000030890 (Evidence)
Entrez Gene16202 (Evidence)
EC2.7.11.1
Consensus CDS ProjectCCDS21659.1
International Mouse Knockout Project StatusIlk
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000025598 VEGA Gene Model | MGI Sequence Detail 6334 C57BL/6J ±  kb
transcript OTTMUST00000062972 VEGA | MGI Sequence Detail 1795 Not Applicable 
polypeptide OTTMUSP00000031102 VEGA | MGI Sequence Detail 452 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(8) UniProt(5)
Polymorphisms
SNPs within 2kb(38 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR016253 Integrin-linked protein kinase
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology PR:000009009 integrin-linked protein kinase
References
(Earliest) J:43595 Li F, et al., Identification and characterization of a mouse protein kinase that is highly homologous to human integrin-linked kinase. Biochim Biophys Acta. 1997 Oct 11;1358(3):215-20
(Latest) J:208648 Montani L, et al., Profilin 1 is required for peripheral nervous system myelination. Development. 2014 Apr;141(7):1553-61
All references(108)
Other
accession IDs
MGI:1201384

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/18/2014
MGI 5.20
The Jackson Laboratory