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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID
Ilk
integrin linked kinase
MGI:1195267
95 phenotypes from 6 alleles in 9 genetic backgrounds
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Allelic Composition
Genetic Background
Annotated Term Reference
Ilktm1.1(KOMP)Vlcg/Ilk+
C57BL/6N-Ilktm1.1(KOMP)Vlcg/J
abnormal embryo size J:211773
hyperactivity J:211773
increased circulating phosphate level J:211773
increased vertical activity J:211773
Ilktm1.1(KOMP)Vlcg/Ilktm1.1(KOMP)Vlcg
C57BL/6N-Ilktm1.1(KOMP)Vlcg/J
embryonic lethality prior to organogenesis J:211773
preweaning lethality, complete penetrance J:211773
Ilktm1Ref/Ilktm1Ref
Not Specified
abnormal basement membrane morphology J:82761
abnormal embryonic epiblast morphology J:82761
embryonic lethality between implantation and somite formation, complete penetrance J:82761
Ilktm1Star/Ilktm1Star
involves: 129S1/Sv * 129X1/SvJ
abnormal keratinocyte morphology J:172934
decreased keratinocyte migration J:172934
Ilktm1Star/Ilktm1Star
Tg(Ckmm-cre)1Lrsn/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N
abnormal heart echocardiography feature J:112174
abnormal heart morphology J:112174
cardiac interstitial fibrosis J:112174
congestive heart failure J:112174
decreased cardiac muscle contractility J:112174
dilated cardiomyopathy J:112174
dilated heart left ventricle J:112174
enlarged heart J:112174
premature death J:112174
Ilktm1Star/Ilktm1Star
Tg(Col2a1-cre)1Star/?
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal skeleton development J:84273
chondrodystrophy J:84273
disproportionate dwarf J:84273
Ilktm1Star/Ilktm1Star
Tg(Krt1-15-cre/PGR*)22Cot/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL/J
delayed wound healing J:172933
Ilktm1Star/Ilktm1Star
Tg(KRT14-cre)1Amc/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
abnormal epidermal layer morphology J:172934
abnormal hair follicle development J:172934
abnormal hair follicle physiology J:172934
abnormal hair growth J:172934
abnormal skin pigmentation J:172934
acanthosis J:172934
blistering J:172934
decreased hair follicle number J:172934
decreased keratinocyte proliferation J:172934
decreased skin tensile strength J:172934
postnatal growth retardation J:172934
postnatal lethality, complete penetrance J:172934
scaly skin J:172934
skin edema J:172934
skin inflammation J:172934
thin skin J:172934
Ilktm1Star/Ilktm1Star
Tg(NPHS2-cre)295Lbh/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
abnormal glomerular capillary morphology J:129244
abnormal glomerular filtration barrier function J:129244
abnormal kidney morphology J:129244
abnormal podocyte morphology J:129244, J:129286
abnormal podocyte slit diaphragm morphology J:129244, J:129286
abnormal renal glomerulus basement membrane morphology J:129244, J:129286
abnormal renal glomerulus morphology J:129286
albuminuria J:129244, J:129286
decreased body weight J:129286
decreased podocyte number J:129286
decreased survivor rate J:129286
detached podocyte J:129244, J:129286
dilated renal tubule J:129286
expanded mesangial matrix J:129244, J:129286
fused podocyte foot processes J:129286
glomerular crescent J:129244
glomerulosclerosis J:129244, J:129286
increased blood urea nitrogen level J:129244
increased circulating cholesterol level J:129244
increased circulating creatinine level J:129286
increased kidney apoptosis J:129286
increased podocyte apoptosis J:129286
increased renal glomerulus basement membrane thickness J:129244, J:129286
increased urine protein level J:129244, J:129286
kidney failure J:129244, J:129286
podocyte foot process effacement J:129244, J:129286
podocyte microvillus transformation J:129244, J:129286
premature death J:129244, J:129286
renal glomerular synechia J:129244
renal glomerulus hypertrophy J:129286
renal interstitial fibrosis J:129244, J:129286
renal tubule atrophy J:129244
tubulointerstitial nephritis J:129244, J:129286
Ilktm1Star/Ilktm2Star
Tg(Acp5-cre)1Star/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6
abnormal osteoclast physiology J:197593
normal craniofacial phenotype J:197593
normal growth/size/body region phenotype J:197593
increased bone volume J:197593
increased osteoclast cell number J:197593
increased trabecular bone thickness J:197593
Ilktm3Ref/Ilktm3Ref
involves: 129S1/Sv * 129X1/SvJ
abnormal ureteric bud morphology J:154054
Ilktm3Ref/Ilktm3Ref
Tg(Col2a1-cre)1Asz/0
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA
abnormal cell adhesion J:110783
abnormal cell cycle J:110783
abnormal chest morphology J:110783
abnormal long bone hypertrophic chondrocyte zone J:110783
cleft palate J:110783
decreased cell proliferation J:110783
decreased fetal size J:110783
decreased long bone epiphyseal plate size J:110783
disorganized long bone epiphyseal plate J:110783
disproportionate dwarf J:110783
neonatal lethality, complete penetrance J:110783
pulmonary hypoplasia J:110783
Ilktm10.1Ref/Ilktm10.1Ref
B6.129(Cg)-Ilktm10.1Ref
absent vitelline blood vessels J:199658
delayed embryo turning J:199658
embryonic growth retardation J:199658
embryonic lethality between somite formation and embryo turning, incomplete penetrance J:199658
embryonic lethality during organogenesis, complete penetrance J:199658

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory