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Tnfaip6 Gene Detail
Summary
  • Symbol
    Tnfaip6
  • Name
    tumor necrosis factor alpha induced protein 6
  • Synonyms
    Tnfip6, Tsg6, TSG-6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195266
    NCBI Gene: 21930
  • Gene Overview
    MyGene.info: TNFAIP6
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:52038113-52056681 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 29.98 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    300 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1195266
protein coding gene Chr2:52038009-52056686 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025731
protein coding gene Chr2:51350290-51371109 (+)
A/J MGP_AJ_G0025707
protein coding gene Chr2:49370134-49389491 (+)
AKR/J MGP_AKRJ_G0025677
protein coding gene Chr2:50795430-50814865 (+)
BALB/cJ MGP_BALBcJ_G0025702
protein coding gene Chr2:49466103-49484744 (+)
C3H/HeJ MGP_C3HHeJ_G0025463
protein coding gene Chr2:50790232-50809737 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026148
protein coding gene Chr2:52856976-52878769 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023554
protein coding gene Chr2:47353595-47370868 (+)
CAST/EiJ MGP_CASTEiJ_G0024928
protein coding gene Chr2:50896597-50916597 (+)
CBA/J MGP_CBAJ_G0025443
protein coding gene Chr2:54867407-54891183 (+)
DBA/2J MGP_DBA2J_G0025574
protein coding gene Chr2:49017537-49040335 (+)
FVB/NJ MGP_FVBNJ_G0025536
protein coding gene Chr2:48705092-48723665 (+)
LP/J MGP_LPJ_G0025662
protein coding gene Chr2:51238295-51257085 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025567
protein coding gene Chr2:55916263-55934868 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026206
protein coding gene Chr2:50701628-50721394 (+)
PWK/PhJ MGP_PWKPhJ_G0024669
protein coding gene Chr2:48893955-48912665 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024475
protein coding gene Chr2:50906721-50927711 (+)
WSB/EiJ MGP_WSBEiJ_G0024995
protein coding gene Chr2:50992477-51013054 (+)



Homology
more
  • Human Ortholog
    TNFAIP6, TNF alpha induced protein 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TNFAIP6, TNF alpha induced protein 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    TSG6, TSG-6
  • Links
    NCBI Gene ID: 7130
    neXtProt AC: NX_P98066
    UniProt: P98066

  • Chr Location
    2q23.3; chr2:151357592-151380048 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Females lacking functional copies of this gene are infertile due to failed cumulus-oocyte complex expansion. Mice show attenuated acute allergic pulmonary inflammation and are resistant to induction of airway hyperresponsiveness.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 21930 NCBI Gene Model | MGI Sequence Detail 18569 C57BL/6J ±  kb
transcript NM_009398 RefSeq | MGI Sequence Detail 1601 C57BL/6  
polypeptide O08859 UniProt | EBI | MGI Sequence Detail 275 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 12
    Genomic 1
    cDNA 11

    Microarray probesets 3
References
more
  • Summaries
    All 41
    Gene Ontology 6
    Phenotypes 9
  • Earliest
    J:44617 Fulop C, et al., Coding sequence, exon-intron structure and chromosomal localization of murine TNF-stimulated gene 6 that is specifically expressed by expanding cumulus cell-oocyte complexes. Gene. 1997 Nov 20;202(1-2):95-102
  • Latest
    J:254672 Di G, et al., Mesenchymal Stem Cells Promote Diabetic Corneal Epithelial Wound Healing Through TSG-6-Dependent Stem Cell Activation and Macrophage Switch. Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):4344-4354

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory