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Per2
Gene Detail
Symbol

Name
ID
Per2
period circadian clock 2
MGI:1195265
Synonyms
mKIAA0347, mPer2
Feature Type
protein coding gene
Genetic Map
Chromosome 1
46.13 cM, cytoband C5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:91415982-91459324 bp, - strand
From VEGA annotation of GRCm38

  43343 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7885  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: PER2
Gene Tree: Per2

Human
homologs
PER2, period circadian clock 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8864
neXtProt AC: NX_O15055

Human Synonyms: FASPS, FASPS1

Human Chr (Location): 2q37.3; chr2:238244038-238290102 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PER2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Targeted(9) Transgenic(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mutants have a partially functional circadian clock, exhibiting a short circadian period followed by loss of circadian rhythmicity in constant darkness. Mutants are also deficient in DNA damage responses and show increased sensitivity to gamma radiation and tumor development.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Per2 interacts with 288 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (16 records)
Data Summary: Results (382)    Tissues (199)    Images (77)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 364
RT-PCR 11
cDNA source data(13)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase per2 ; ZFIN per2    NEW 
Molecular
reagents
All nucleic(16) cDNA(13) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000048493 (Evidence)
Ensembl Gene Model ENSMUSG00000055866 (Evidence)
Entrez Gene 18627 (Evidence)
DFCI TC1579956, TC1606867
DoTS DT.91369157, DT.60101432
Consensus CDS Project CCDS35663.1
International Mouse Phenotyping Consortium Status Per2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048493 VEGA Gene Model | MGI Sequence Detail 43343 C57BL/6J ±  kb
transcript OTTMUST00000124300 VEGA | MGI Sequence Detail 5833 Not Applicable 
polypeptide OTTMUSP00000067668 VEGA | MGI Sequence Detail 1257 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(6)
Polymorphisms
SNPs within 2kb(409 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000012548 period circadian protein homolog 2
References
(Earliest) J:44820 Albrecht U, et al., A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light. Cell. 1997 Dec 26;91(7):1055-64
(Latest) J:220692 Papp SJ, et al., DNA damage shifts circadian clock time via Hausp-dependent Cry1 stabilization. Elife. 2015;4
All references(227)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory