Per2
Gene Detail

Symbol Name ID

Per2 period circadian clock 2 MGI:1195265

Synonyms

mKIAA0347, mPer2

Feature Type

protein coding gene

Genetic Map

Chromosome 1

46.13 cM, cytoband C5
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:91415982-91459328 bp, - strand From NCBI annotation of GRCm38   43347 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Per2 ± 2 cM)

Gene Tree: Per2

Human ortholog

PER2 period circadian clock 2 NCBI Gene ID 8864
Human Synonyms: FASPS
Human Chr2:239152679-239197207 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human PER2 (1)

Alleles and phenotypes

All alleles(9) : Targeted(9)
 

Homozygous null mutants have a partially functional circadian clock, exhibiting a short circadian period followed by loss of circadian rhythmicity in constant darkness. Mutants are also deficient in DNA damage responses and show increased sensitivity to gamma radiation and tumor development.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	circadian rhythm, negative regulation of transcription from RNA polymerase II promoter, ...
Component	cytoplasm, nucleus
Function	protein binding, protein binding transcription factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (16 records)
Data Summary: Results (382)    Tissues (189)    Images (77)
Theiler Stages: 17, 19, 21, 22, 23, 25, 28

Assay Type	Results
Immunohistochemistry	7
RNA in situ	364
RT-PCR	11

cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(12) Primer pair(2) Other(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000055866 (Evidence)
Entrez Gene	18627 (Evidence)
DFCI	TC1579956, TC1606867
DoTS	DT.60101432, DT.91369157
PDB	3GDI
Consensus CDS Project	CCDS35663.1
International Mouse Knockout Project Status	Per2

Sequences

Length	Strain/Species
genomic	18627	NCBI Gene Model | MGI Sequence Detail	43347	C57BL/6J
transcript	NM_011066	RefSeq | MGI Sequence Detail	5845	C57BL/6
polypeptide	O54943	UniProt | EBI | MGI Sequence Detail	1257	Not Applicable

All sequences(26) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(353 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001610	PAC motif
InterPro	IPR000014	PAS domain
InterPro	IPR013655	PAS fold-3
InterPro	IPR022728	Period circadian-like, C-terminal
Protein Ontology	PR:000012548	period circadian protein 2

Graphical View of Protein Domain Structure

References

(Earliest) J:44820 Albrecht U, et al., A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light. Cell. 1997 Dec 26;91(7):1055-64
(Latest) J:193434 Carvas JM, et al., Period2 gene mutant mice show compromised insulin-mediated endothelial nitric oxide release and altered glucose homeostasis. Front Physiol. 2012;3:337
All references(184)