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Per2 Gene Detail
Summary
  • Symbol
    Per2
  • Name
    period circadian clock 2
  • Synonyms
    mKIAA0347, mPer2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1195265
    NCBI Gene: 18627
  • Gene Overview
    MyGene.info: PER2
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:91415982-91459324 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 46.13 cM, cytoband C5
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    405 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1195265
protein coding gene Chr1:91415977-91459402 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016310
protein coding gene Chr1:92958230-93001791 (-)
A/J MGP_AJ_G0016291
protein coding gene Chr1:89609984-89653299 (-)
AKR/J MGP_AKRJ_G0016252
protein coding gene Chr1:92271196-92314260 (-)
BALB/cJ MGP_BALBcJ_G0016247
protein coding gene Chr1:89796125-89841744 (-)
C3H/HeJ MGP_C3HHeJ_G0016076
protein coding gene Chr1:92493092-92535876 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016706
protein coding gene Chr1:96520397-96563842 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014424
protein coding gene Chr1:83869033-83912193 (-)
CAST/EiJ MGP_CASTEiJ_G0015661
protein coding gene Chr1:91836637-91881808 (-)
CBA/J MGP_CBAJ_G0016052
protein coding gene Chr1:99607366-99652214 (-)
DBA/2J MGP_DBA2J_G0016155
protein coding gene Chr1:88841122-88883598 (-)
FVB/NJ MGP_FVBNJ_G0016154
protein coding gene Chr1:87871753-87916236 (-)
LP/J MGP_LPJ_G0016226
protein coding gene Chr1:94131188-94174091 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016179
protein coding gene Chr1:102849927-102893976 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016746
protein coding gene Chr1:92295543-92338163 (-)
PWK/PhJ MGP_PWKPhJ_G0015445
protein coding gene Chr1:88255103-88298335 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015228
protein coding gene Chr1:91217696-91263830 (-)
WSB/EiJ MGP_WSBEiJ_G0015719
protein coding gene Chr1:92093257-92135969 (-)



Homology
more
  • Human Ortholog
    PER2, period circadian regulator 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    PER2, period circadian regulator 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FASPS, FASPS1
  • Links
    NCBI Gene ID: 8864
    neXtProt AC: NX_O15055
    UniProt: O15055

  • Chr Location
    2q37.3; chr2:238244038-238290102 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Per2 mouse models; 1 with human PER2 associations

Human Disease Mouse Models
      
IDs
View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    49 phenotypes from 6 alleles in 7 genetic backgrounds
    23 phenotypes from multigenic genotypes
    237 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mutants have a partially functional circadian clock, exhibiting a short circadian period followed by loss of circadian rhythmicity in constant darkness. Mutants are also deficient in DNA damage responses and show increased sensitivity togamma radiation and tumor development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000055866 Ensembl Gene Model | MGI Sequence Detail 43343 C57BL/6J ±  kb
    transcript ENSMUST00000069620 Ensembl | MGI Sequence Detail 5833 Not Applicable  
    polypeptide ENSMUSP00000066620 Ensembl | MGI Sequence Detail 1257 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 14
      Primer pair 2
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 380
      Developmental Gene Expression 19
      Diseases 2
      Gene Ontology 54
      Phenotypes 237
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:266644 Walter LM, et al., Light modulation ameliorates expression of circadian genes and disease progression in spinal muscular atrophy mice. Hum Mol Genet. 2018 Oct 15;27(20):3582-3597

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/27/2018
    MGI 6.13
    The Jackson Laboratory