Dsc3
Gene Detail

Symbol Name ID

Dsc3 desmocollin 3 MGI:1194993

Synonyms

5430426I24Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 18

11.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr18:19960930-20002097 bp, - strand From NCBI annotation of GRCm38   41168 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1462  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Gene Tree: Dsc3

Human homologs

Human Homolog		DSC3, desmocollin 3
NCBI Gene ID		1825
neXtProt AC		NX_Q14574
Human Synonyms		CDHF3, DSC, DSC1, DSC2, DSC4, HT-CP
Human Chr (Location)		18q12.1; chr18:28570052-28622781 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human DSC3

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous null mice die before implantation. Heterozygous mice do not display any gross abnormalities and have normal epidermal development and keratinocyte differentiation.

 

Gene Ontology (GO) classifications

All GO classifications: (16 annotations)

Process	cell adhesion, homophilic cell adhesion, ...
Component	cell junction, cytoplasm, ...
Function	calcium ion binding, gamma-catenin binding, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (53)    Tissues (50)    Images (3)
Theiler Stages: 20, 21, 23, 25

Assay Type	Results
Immunohistochemistry	6
RNA in situ	47

cDNA source data(24)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(26) cDNA(25) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000059898 (Evidence)
Entrez Gene	13507 (Evidence)
UniGene	89935
DFCI	TC1609783, TC1700417
DoTS	DT.101205167, DT.40173393, DT.91332354
NIA Mouse Gene Index	U144854
Consensus CDS Project	CCDS37744.1
International Mouse Knockout Project Status	Dsc3

Sequences

Length	Strain/Species
genomic	13507	NCBI Gene Model | MGI Sequence Detail	41168	C57BL/6J
transcript	NM_007882	RefSeq | MGI Sequence Detail	5305	C57BL/6
polypeptide	P55850	UniProt | EBI | MGI Sequence Detail	895	Not Applicable

All sequences(26) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(89 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002126	Cadherin
InterPro	IPR020894	Cadherin conserved site
InterPro	IPR000233	Cadherin, cytoplasmic domain
InterPro	IPR009124	Cadherin/Desmocollin
InterPro	IPR015919	Cadherin-like
InterPro	IPR014868	Cadherin prodomain
InterPro	IPR009122	Desmosomal cadherin
Protein Ontology	PR:000006694	desmocollin-3

Graphical View of Protein Domain Structure

References

(Earliest) J:18927 Buxton RS, et al., Mouse desmocollin (Dsc3) and desmoglein (Dsg1) genes are closely linked in the proximal region of chromosome 18. Genomics. 1994 Jun;21(3):510-6
(Latest) J:191121 Ferone G, et al., p63 control of desmosome gene expression and adhesion is compromised in AEC syndrome. Hum Mol Genet. 2013 Feb 1;22(3):531-43
All references(40)

Other accession IDs

MGI:1918578