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Dsc3
Gene Detail
 Symbol
Name
ID
Dsc3
desmocollin 3
MGI:1194993
Synonyms 5430426I24Rik
Feature Type protein coding gene
Genetic Map
Chromosome 18
11.11 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:19960930-20002097 bp, - strand
From NCBI annotation of GRCm38

  41168 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1462  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog

Gene Tree: Dsc3

Human
homologs
Human Homolog DSC3, desmocollin 3
NCBI Gene ID 1825
neXtProt AC  NX_Q14574
Human Synonyms  CDHF3, DSC, DSC1, DSC2, DSC4, HT-CP
Human Chr (Location)  18q12.1; chr18:30990086-31042815 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human DSC3
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice die before implantation. Heterozygous mice do not display any gross abnormalities and have normal epidermal development and keratinocyte differentiation.
 
Interactions
Dsc3 interacts with 323 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell adhesion, homophilic cell adhesion, ...
Component cell junction, cytoplasm, ...
Function calcium ion binding, gamma-catenin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (53)    Tissues (50)    Images (3)
Theiler Stages: 20, 21, 23, 25
Assay TypeResults
Immunohistochemistry 6
RNA in situ 47
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) cDNA(25) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000059898 (Evidence)
Entrez Gene13507 (Evidence)
UniGene89935
DFCITC1609783, TC1700417
DoTSDT.101205167, DT.40173393, DT.91332354
NIA Mouse Gene IndexU144854
Consensus CDS ProjectCCDS37744.1
International Mouse Knockout Project StatusDsc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13507 NCBI Gene Model | MGI Sequence Detail 41168 C57BL/6J ±  kb
transcript NM_001291809 RefSeq | MGI Sequence Detail 5348 C57BL/6 
polypeptide P55850 UniProt | EBI | MGI Sequence Detail 895 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(10) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(386 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002126 Cadherin
InterPro IPR020894 Cadherin conserved site
InterPro IPR000233 Cadherin, cytoplasmic domain
InterPro IPR009124 Cadherin/Desmocollin
InterPro IPR015919 Cadherin-like
InterPro IPR014868 Cadherin prodomain
InterPro IPR027397 Catenin binding domain
InterPro IPR009122 Desmosomal cadherin
Protein Ontology PR:000006694 desmocollin-3
Graphical View of Protein Domain Structure
References (Earliest) J:18927 Buxton RS, et al., Mouse desmocollin (Dsc3) and desmoglein (Dsg1) genes are closely linked in the proximal region of chromosome 18. Genomics. 1994 Jun;21(3):510-6
(Latest) J:202875 Tokonzaba E, et al., Plakoglobin as a regulator of desmocollin gene expression. J Invest Dermatol. 2013 Dec;133(12):2732-40
All references(41)
Other
accession IDs
MGI:1918578

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory