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Dsc3 Gene Detail
Summary
  • Symbol
    Dsc3
  • Name
    desmocollin 3
  • Synonyms
    5430426I24Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194993
    NCBI Gene: 13507
  • Gene Overview
    MyGene.info: DSC3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr18:19960930-20002351 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      41422 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 11.11 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DSC3, desmocollin 3
  • Vertebrate Orthologs
    6
  • Human Ortholog
    DSC3, desmocollin 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDHF3, DSC, DSC1, DSC2, DSC4, HT-CP
  • Links
    NCBI Gene ID: 1825
    neXtProt AC: NX_Q14574
    UniProt: Q14574

  • Chr Location
    18q12.1; chr18:30989365-31042815 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    13 phenotypes from 2 alleles in 3 genetic backgrounds
    6 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice die before implantation. Heterozygous mice do not display any gross abnormalities and have normal epidermal development and keratinocyte differentiation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000059898 Ensembl Gene Model | MGI Sequence Detail 41422 C57BL/6J ±  kb
    transcript ENSMUST00000225110 Ensembl | MGI Sequence Detail 3123 Not Applicable  
    polypeptide ENSMUSP00000153261 Ensembl | MGI Sequence Detail 896 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      384 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 26
      cDNA 25
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1918578
    References
    more
    • Summaries
      All 39
      Developmental Gene Expression 11
      Gene Ontology 6
      Phenotypes 6
    • Earliest
      J:18927 Buxton RS, et al., Mouse desmocollin (Dsc3) and desmoglein (Dsg1) genes are closely linked in the proximal region of chromosome 18. Genomics. 1994 Jun;21(3):510-6
    • Latest
      J:253459 Inoue SI, et al., Activated Braf induces esophageal dilation and gastric epithelial hyperplasia in mice. Hum Mol Genet. 2017 Dec 1;26(23):4715-4727

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/08/2018
    MGI 6.12
    The Jackson Laboratory