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Crx Gene Detail
Summary
  • Symbol
    Crx
  • Name
    cone-rod homeobox
  • Synonyms
    Crx1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194883
    NCBI Gene: 12951
  • Gene Overview
    MyGene.info: CRX
Location & Maps
more
  • Sequence Map
    Chr7:15865947-15879968 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14022 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 8.60 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    CRX, cone-rod homeobox
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CRX, cone-rod homeobox
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CORD2, CRD, LCA7, OTX3
  • Links
    NCBI Gene ID: 1406
    neXtProt AC: NX_O43186

  • Chr Location
    19q13.3; chr19:47821842-47843330 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Crx mouse models; 3 with human CRX associations

Human Disease Mouse Models
       Leber Congenital Amaurosis 7; LCA7   OMIM: 613829 View 2 models
       Cone-Rod Dystrophy 2; CORD2   OMIM: 120970
Retinitis Pigmentosa; RP   OMIM: 268000
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 6 alleles in 7 genetic backgrounds
    4 phenotypes from multigenic genotypes
    14 images
    25 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    7
  • Chemically induced (ENU)
    1
  • Gene trapped
    1
  • Spontaneous
    1
  • Targeted
    4
  • Incidental Mutations
Homozygotes for a targeted null mutation exhibit a lack of photoreceptor outer segments and rod and cone activity, reduced expression of several photoreceptor- and pineal-specific genes, and altered circadian behavior.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029352 VEGA Gene Model | MGI Sequence Detail 14022 C57BL/6J ±  kb
transcript OTTMUST00000096852 VEGA | MGI Sequence Detail 2880 Not Applicable  
polypeptide OTTMUSP00000054167 VEGA | MGI Sequence Detail 323 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    63 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 94
    Genomic 3
    cDNA 83
    Primer pair 7
    Other 1

    Microarray probesets 4
References
more
  • Summaries
    All 122
    Developmental Gene Expression 62
    Diseases 2
    Gene Ontology 11
    Phenotypes 25
  • Earliest
    J:44327 Chen S, et al., Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes. Neuron. 1997 Nov;19(5):1017-30
  • Latest
    J:229933 Faits MC, et al., Dendritic mitochondria reach stable positions during circuit development. Elife. 2016;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory