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Crx
Gene Detail
 Symbol
Name
ID
Crx
cone-rod homeobox
MGI:1194883
Synonyms Crx1
Feature Type protein coding gene
Genetic Map
Chromosome 7
8.60 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr7:15865947-15879968 bp, - strand
From VEGA annotation of GRCm38

  14022 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:467  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Gene Tree: Crx

Human
homologs
Human Homolog CRX, cone-rod homeobox
NCBI Gene ID 1406
neXtProt AC  NX_O43186
Human Synonyms  CORD2, CRD, LCA7, OTX3
Human Chr (Location)  19q13.3; chr19:47821842-47843330 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human CRX
Alleles
and
phenotypes
All alleles(4) : Targeted(1) Gene trapped(1) Spontaneous(1) Chemically induced(1)
 
Homozygotes for a targeted null mutation exhibit a lack of photoreceptor outer segments and rod and cone activity, reduced expression of several photoreceptor- and pineal-specific genes, and altered circadian behavior.
 
Human Diseases Modeled Using Mouse Crx (1)    Alleles Annotated to Human Diseases(2)    Phenotype Images(7)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process multicellular organismal development, positive regulation of transcription from RNA polymerase II promoter, ...
Component nucleus, transcription factor complex
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (54 records)
Data Summary: Results (265)    Tissues (180)    Images (44)
Theiler Stages: 2, 3, 4, 5, 15, 17, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 190
Northern blot 10
Western blot 1
RT-PCR 62
cDNA source data(82)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(94) Genomic(3) cDNA(83) Primer pair(7) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000029352 (Evidence)
Ensembl Gene ModelENSMUSG00000041578 (Evidence)
Entrez Gene12951 (Evidence)
UniGene441911
DFCITC1579975, TC1607973
DoTSDT.101317294, DT.60100260
NIA Mouse Gene IndexU028171
Consensus CDS ProjectCCDS20840.1, CCDS52035.1
International Mouse Knockout Project StatusCrx
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029352 VEGA Gene Model | MGI Sequence Detail 14022 C57BL/6J ±  kb
transcript OTTMUST00000096852 VEGA | MGI Sequence Detail 2879 Not Applicable 
polypeptide OTTMUSP00000054167 VEGA | MGI Sequence Detail 323 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(4) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(64 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR013851 Transcription factor Otx, C-terminal
Protein Ontology PR:000005904 cone-rod homeobox protein
References (Earliest) J:44327 Chen S, et al., Crx, a novel Otx-like paired-homeodomain protein, binds to and transactivates photoreceptor cell-specific genes. Neuron. 1997 Nov;19(5):1017-30
(Latest) J:203337 Roger JE, et al., OTX2 loss causes rod differentiation defect in CRX-associated congenital blindness. J Clin Invest. 2014 Jan 2;
All references(111)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory