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Symbol
Name
ID

Crx
cone-rod homeobox
MGI:1194883

Phenotype annotations related to vision/eye

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Human Phenotypes

Keratoconus

Cataract

Chorioretinal atrophy

Macular hyperpigmentation

Bone spicule pigmentation of the retina

Retinal pigment epithelial atrophy

Cone/cone-rod dystrophy

Abnormal electroretinogram

Undetectable electroretinogram

Nystagmus

Pendular nystagmus

Color vision defect

Metamorphopsia

Nyctalopia

Photophobia

Visual impairment

Reduced visual acuity

Blindness

Constriction of peripheral visual field

Peripheral visual field loss

Central scotoma

Disease(s) Associated with CRX

cone-rod dystrophy 2

Leber congenital amaurosis 7

Mouse Phenotypes

vision/eye phenotype

abnormal retina blood vessel morphology

decreased retina cone cell number

abnormal retina bipolar cell morphology

abnormal retina cone bipolar cell morphology

abnormal retina rod bipolar cell morphology

abnormal retina horizontal cell morphology

abnormal retina photoreceptor morphology

abnormal photoreceptor inner segment morphology

absent photoreceptor inner segment

short photoreceptor inner segment

abnormal photoreceptor outer segment morphology

absent photoreceptor outer segment

short retina rod cell outer segment

abnormal retina cone cell morphology

retina photoreceptor degeneration

abnormal retina pigmentation

abnormal retina progenitor cell morphology

abnormal ocular fundus morphology

abnormal retina morphology

abnormal retina layer morphology

abnormal retina outer nuclear layer morphology

abnormal retina outer nuclear layer thickness

thin retina outer nuclear layer

disorganized retina outer nuclear layer

retina outer nuclear layer degeneration

abnormal retina outer plexiform layer morphology

thin retina outer plexiform layer

abnormal retina photoreceptor layer morphology

retina spots

abnormal electroretinogram waveform feature

decreased a-wave amplitude

decreased b-wave amplitude

abnormal eye electrophysiology

abnormal cone electrophysiology

abnormal rod electrophysiology

absent visual evoked potential

blindness

binocular blindness

Availability

Mouse Genotype

Crx^{em1(IMPC)Ccpcz}/Crx^{em1(IMPC)Ccpcz}

Crx^em1Smgc/Crx^em1Smgc

*

Crx^em2Smgc/Crx^em2Smgc

Crx^Rip/Crx^Rip

Crx^tm1.1Smgc/Crx^tm1.1Smgc

*

Crx^tm1Clc/Crx^tm1Clc

*

Crx^tm2.1Smgc/Crx^tm2.1Smgc

*

Crx^tvrm65/Crx^tvrm65

Crx^em1Smgc/Crx⁺

*

Crx^em2Smgc/Crx⁺

Crx^Rip/Crx⁺

*

Crx^tm1.1Smgc/Crx⁺

Crx^tm1Clc/Crx⁺

Crx^tm1Smgc/Crx⁺

*

Crx^tm2.1Smgc/Crx⁺

*

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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