Serpini1
Gene Detail

Symbol Name ID

Serpini1 serine (or cysteine) peptidase inhibitor, clade I, member 1 MGI:1194506

Synonyms

Neuroserpin, Ns, PI12, Spi17

Feature Type

protein coding gene

Genetic Map

Chromosome 3

33.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr3:75557547-75643495 bp, + strand From VEGA annotation of GRCm38   85949 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21045  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: serpin
Gene Tree: Serpini1

Human homologs

Human Homolog		SERPINI1, serpin peptidase inhibitor, clade I (neuroserpin), member 1
NCBI Gene ID		5274
neXtProt AC		NX_Q99574
Human Synonyms		neuroserpin, PI12
Human Chr (Location)		3q26.1; chr3:167453432-167543357 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SERPINI1

Alleles and phenotypes

All alleles(5) : Targeted(4) Gene trapped(1)
 

Mice homozygous for a disruption in this gene show no change in brain morphology or histology. However, they show an increase avoidance of novel stimuli and increased anxiety responses in some situations.

 
Human Diseases Modeled Using Mouse Serpini1 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (8 annotations)

Process	negative regulation of endopeptidase activity, negative regulation of peptidase activity, ...
Component	extracellular region
Function	peptidase inhibitor activity, serine-type endopeptidase inhibitor activity

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (51)    Tissues (35)    Images (18)
Theiler Stages: 1, 2, 3, 5, 17, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
RNA in situ	37
RT-PCR	14

cDNA source data(7)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(21) Genomic(11) cDNA(9) Primer pair(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000021878 (Evidence)
Ensembl Gene Model	ENSMUSG00000027834 (Evidence)
Entrez Gene	20713 (Evidence)
DFCI	TC1576132, TC1760077
DoTS	DT.40179557, DT.91279089
NIA Mouse Gene Index	U003338
PDB	1JJO
Consensus CDS Project	CCDS17415.1
International Mouse Knockout Project Status	Serpini1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021878	VEGA Gene Model | MGI Sequence Detail	85949	C57BL/6J
transcript	OTTMUST00000051936	VEGA | MGI Sequence Detail	4091	Not Applicable
polypeptide	OTTMUSP00000024524	VEGA | MGI Sequence Detail	410	Not Applicable

All sequences(28) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(485 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023795	Protease inhibitor I4, serpin, conserved site
InterPro	IPR023796	Serpin domain
InterPro	IPR000215	Serpin family
Protein Ontology	PR:000014709	neuroserpin

References

(Earliest) J:44285 Krueger SR, et al., Expression of neuroserpin, an inhibitor of tissue plasminogen activator, in the developing and adult nervous system of the mouse. J Neurosci. 1997 Dec 1;17(23):8984-96
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(43)

Other accession IDs

MGI:2139802