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Serpini1
Gene Detail
Symbol

Name
ID
Serpini1
serine (or cysteine) peptidase inhibitor, clade I, member 1
MGI:1194506
Synonyms
Neuroserpin, Ns, PI12, Spi17
Feature Type
protein coding gene
Genetic Map
Chromosome 3
33.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr3:75557547-75643495 bp, + strand
From VEGA annotation of GRCm38

  85949 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21045  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SERPINI1
Protein SuperFamily: serpin
Gene Tree: Serpini1

Human
homologs
SERPINI1, serpin peptidase inhibitor, clade I (neuroserpin), member 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5274
neXtProt AC: NX_Q99574

Human Synonyms: neuroserpin, PI12

Human Chr (Location): 3q26.1; chr3:167735644-167825569 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SERPINI1

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(1) Targeted(4) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a disruption in this gene show no change in brain morphology or histology. However, they show an increase avoidance of novel stimuli and increased anxiety responses in some situations.
 
Human Diseases Modeled in Mice Using Serpini1 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Serpini1 interacts with 327 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (9 records)
Data Summary: Results (47)    Tissues (35)    Images (18)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 37
RT-PCR 10
cDNA source data(8)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase serpini1 ; ZFIN serpini1    NEW 
Molecular
reagents
All nucleic(22) Genomic(11) cDNA(10) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000021878 (Evidence)
Ensembl Gene Model ENSMUSG00000027834 (Evidence)
Entrez Gene 20713 (Evidence)
DFCI TC1576132, TC1760077
DoTS DT.40179557, DT.91279089
NIA Mouse Gene Index U003338
PDB 1JJO
Consensus CDS Project CCDS17415.1
International Mouse Phenotyping Consortium Status Serpini1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021878 VEGA Gene Model | MGI Sequence Detail 85949 C57BL/6J ±  kb
transcript OTTMUST00000051936 VEGA | MGI Sequence Detail 4091 Not Applicable 
polypeptide OTTMUSP00000024524 VEGA | MGI Sequence Detail 410 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(613 from dbSNP Build 137)    SNPs within 2kb including multiple locations(615)
Protein-related
information
ResourceIDDescription
InterPro IPR023795 Serpin, conserved site
InterPro IPR023796 Serpin domain
InterPro IPR000215 Serpin family
Protein Ontology PR:000014709 neuroserpin
References
(Earliest) J:44285 Krueger SR, et al., Expression of neuroserpin, an inhibitor of tissue plasminogen activator, in the developing and adult nervous system of the mouse. J Neurosci. 1997 Dec 1;17(23):8984-96
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(46)
Disease annotation references (1)
Other
accession IDs
MGI:2139802

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory