Serpini1 MGI Mouse Gene Detail - MGI:1194506 - serine (or cysteine) peptidase inhibitor, clade I, member 1

Symbol

Serpini1
Name

serine (or cysteine) peptidase inhibitor, clade I, member 1
Synonyms

Neuroserpin, Ns, PI12, Spi17

Feature Type

protein coding gene
IDs

MGI:1194506
NCBI Gene: 20713
Alliance

genome feature page
Transcription Start Sites

5 TSS

Sequence Map

Chr3:75464800-75549830 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 33.76 cM
Mapping Data

2 experiments

SNPs within 2kb

2579 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1194506	protein coding gene	Chr3:75464800-75550802 (+)
129S1/SvImJ	ENSMUSG00200019014	protein coding gene	Chr3:72180420-72266393 (+)
A/J	ENSMUSG00195011798	protein coding gene	Chr3:72301288-72387178 (+)
AKR/J	ENSMUSG00220001436	protein coding gene	Chr3:72318214-72404136 (+)
BALB/cJ	ENSMUSG00180001847	protein coding gene	Chr3:72380921-72466871 (+)
C3H/HeJ	ENSMUSG00175007357	protein coding gene	Chr3:72259054-72345001 (+)
C57BL/6NJ	ENSMUSG00215001974	protein coding gene	Chr3:72686879-72772829 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025079	protein coding gene	Chr3:68527146-68613227 (+)
CAST/EiJ	ENSTCUG00005021489	protein coding gene	Chr3:71780790-71864841 (+)
CBA/J	ENSMUSG00210025283	protein coding gene	Chr3:72341648-72427602 (+)
DBA/2J	ENSMUSG00185012447	protein coding gene	Chr3:72490472-72582027 (+)
FVB/NJ	ENSMUSG00205009469	protein coding gene	Chr3:71353257-71439178 (+)
JF1/MsJ	ENSUMUG00000001336	protein coding gene	Chr3:72051959-72136119 (+)
LP/J	ENSMUSG00230008917	protein coding gene	Chr3:74472764-74558731 (+)
NOD/ShiLtJ	ENSMUSG00190002636	protein coding gene	Chr3:72824484-72916045 (+)
NZO/HlLtJ	ENSMUSG00225004469	protein coding gene	Chr3:77199654-77285535 (+)
PWK/PhJ	ENSLUMG00010014988	protein coding gene	Chr3:72105000-72190776 (+)
SPRET/EiJ	ENSMSPG00010017082	protein coding gene	Chr3:72730028-72817938 (+)
WSB/EiJ	ENSIUOG00005003036	protein coding gene	Chr3:72678189-72764117 (+)

Human Ortholog

SERPINI1, serpin family I member 1

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

SERPINI1, serpin family I member 1
Synonyms

HNS-S1, HNS-S2, neuroserpin, PI12
Links

HGNC:8943

NCBI Gene ID: 5274

UniProt: Q99574
Chr Location

3q26.1; chr3:167735068-167825573 (+) GRCh38

MGI Vertebrate Homology

Serpini1 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: SERPINI1
Gene Tree

Serpini1

Diseases

1 with Serpini1 mouse models; 1 with human SERPINI1 associations

Human Disease

Mouse Models

familial encephalopathy with neuroserpin inclusion bodies

IDs

View 1 model

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

2 with disease annotations

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Phenotype Summary

4 phenotypes from 1 allele in 1 genetic background
17 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Chemically induced (other)

1
Endonuclease-mediated

1
Gene trapped

1
Radiation induced

1
Targeted

4
Genomic Mutations

2 involving Serpini1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

27 strains or lines available

Mice homozygous for a disruption in this gene show no change in brain morphology or histology. However, they show an increase avoidance of novel stimuli and increased anxiety responses in some situations.

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All GO Annotations

24
GO References

9

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

650
Tissues

41
cDNA Data

9
Literature Summary

11

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

Xenbase serpini1

ZFIN serpini1

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All Sequences

40
RefSeq

4
UniProt

2
CCDS

CCDS17415.1

Ensembl

ENSMUSG00000027834 (Evidence)
NCBI Gene

20713

			Length	Strain/Species	Flank
genomic	20713	NCBI Gene Model \| MGI Sequence Detail	85031	C57BL/6J	± kb
transcript	NM_009250	RefSeq \| MGI Sequence Detail	3173	C57BL/6
polypeptide	O35684	UniProt \| EBI \| MGI Sequence Detail	410	Not Applicable

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UniProt

2 Sequences
Protein Ontology

PR:000014709 neuroserpin

(term hierarchy)
PDB

1JJO
InterPro Domains

IPR023795 Serpin, conserved site

IPR023796 Serpin domain

IPR000215 Serpin family

IPR036186 Serpin superfamily

IPR042178 Serpin superfamily, domain 1

IPR042185 Serpin superfamily, domain 2
GlyGen

O35684 4 sites, 5 N-linked glycans (2 sites)

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All nucleic 23

Genomic 11

cDNA 11

Primer pair 1

Microarray probesets 5

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MGI:2139802

Summaries

All 65

Developmental Gene Expression 11

Diseases 2

Gene Ontology 9

Phenotypes 17
Earliest

J:44285 Krueger SR, et al., Expression of neuroserpin, an inhibitor of tissue plasminogen activator, in the developing and adult nervous system of the mouse. J Neurosci. 1997 Dec 1;17(23):8984-96
Latest

J:385830 Zhang T, et al., Human PSC-derived sinoatrial node-cardiac plexus assembloids model innervation-associated maturation of pacemaker systems. Cell Stem Cell. 2026 May 15;

TSS for Serpini1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr29563	Chr3:75464817-75464828 (+)	23 bp
Tssr29564	Chr3:75464837-75464868 (+)	53 bp
Tssr29565	Chr3:75464883-75464894 (+)	89 bp
Tssr29566	Chr3:75464901-75464912 (+)	107 bp
Tssr29567	Chr3:75470221-75470225 (+)	5,423 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24