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Serpini1 Gene Detail
Summary
  • Symbol
    Serpini1
  • Name
    serine (or cysteine) peptidase inhibitor, clade I, member 1
  • Synonyms
    Neuroserpin, Ns, PI12, Spi17
  • Feature Type
    protein coding gene
  • IDs
    MGI:1194506
    NCBI Gene: 20713
  • Gene Overview
    MyGene.info: SERPINI1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:75557533-75642523 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 33.76 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    600 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1194506
protein coding gene Chr3:75557533-75643495 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027307
protein coding gene Chr3:75029601-75120182 (+)
A/J MGP_AJ_G0027269
protein coding gene Chr3:72703969-72789857 (+)
AKR/J MGP_AKRJ_G0027237
protein coding gene Chr3:74348961-74436839 (+)
BALB/cJ MGP_BALBcJ_G0027280
protein coding gene Chr3:72689874-72776812 (+)
C3H/HeJ MGP_C3HHeJ_G0027024
protein coding gene Chr3:74672899-74761754 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027726
protein coding gene Chr3:77992179-78087341 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025079
protein coding gene Chr3:68527146-68613227 (+)
CAST/EiJ MGP_CASTEiJ_G0026471
protein coding gene Chr3:74622406-74714511 (+)
CBA/J MGP_CBAJ_G0026999
protein coding gene Chr3:80479166-80575491 (+)
DBA/2J MGP_DBA2J_G0027135
protein coding gene Chr3:72254716-72344492 (+)
FVB/NJ MGP_FVBNJ_G0027103
protein coding gene Chr3:70640303-70726204 (+)
LP/J MGP_LPJ_G0027243
protein coding gene Chr3:76034605-76128544 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027122
protein coding gene Chr3:86301675-86418063 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027784
protein coding gene Chr3:74168958-74254571 (+)
PWK/PhJ MGP_PWKPhJ_G0026205
protein coding gene Chr3:71977884-72065972 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026021
protein coding gene Chr3:73255971-73350681 (+)
WSB/EiJ MGP_WSBEiJ_G0026549
protein coding gene Chr3:74442729-74535367 (+)



Homology
more
  • Human Ortholog
    SERPINI1, serpin family I member 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SERPINI1, serpin family I member 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    neuroserpin, PI12
  • Links
    NCBI Gene ID: 5274
    neXtProt AC: NX_Q99574
    UniProt: Q99574

  • Chr Location
    3q26.1; chr3:167735335-167825569 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Serpini1 mouse models; 1 with human SERPINI1 associations

Human Disease Mouse Models
      
IDs
View 3 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a disruption in this gene show no change in brain morphology or histology. However, they show an increase avoidance of novel stimuli and increased anxiety responses in some situations.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20713 NCBI Gene Model | MGI Sequence Detail 84991 C57BL/6J ±  kb
transcript NM_009250 RefSeq | MGI Sequence Detail 3173 C57BL/6  
polypeptide O35684 UniProt | EBI | MGI Sequence Detail 410 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    Genomic 11
    cDNA 11
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
less
MGI:2139802
References
more
  • Summaries
    All 54
    Developmental Gene Expression 9
    Diseases 3
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:44285 Krueger SR, et al., Expression of neuroserpin, an inhibitor of tissue plasminogen activator, in the developing and adult nervous system of the mouse. J Neurosci. 1997 Dec 1;17(23):8984-96
  • Latest
    J:238532 Gu RP, et al., Retina Is Protected by Neuroserpin from Ischemic/Reperfusion-Induced Injury Independent of Tissue-Type Plasminogen Activator. PLoS One. 2015;10(7):e0130440

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory