Phenotypes Associated with This Genotype

Genotype
MGI:2669541

• Allelic Composition: Serpini1^tm1Dpw/Serpini1^tm1Dpw
• Genetic Background: involves: 129/Sv * C57BL/6JBom

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal anxiety-related response ( J:84427 )

• anxiety -like response to the "O-maze"

abnormal response to novelty ( J:84427 )

• increased avoidance of novel stimuli

decreased exploration in new environment ( J:84427 )

• novelty induced hypolocomotion in various testing situations whereas locomotion in familiar environments was unchanged or perhaps slightly elevated

abnormal motor capabilities/coordination/movement ( J:84427 )

• reduced activity during examination or handling

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
familial encephalopathy with neuroserpin inclusion bodies		DOID:0050831	OMIM:604218	J:84427