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Tgif1
Gene Detail
Symbol

Name
ID
Tgif1
TGFB-induced factor homeobox 1
MGI:1194497
Synonyms
Tgif
Feature Type
protein coding gene
Genetic Map
Chromosome 17
41.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr17:70844205-70853546 bp, - strand
From VEGA annotation of GRCm38

  9342 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7574  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TGIF1
Gene Tree: Tgif1

Human
homologs
TGIF1, TGFB-induced factor homeobox 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 7050
neXtProt AC: NX_Q15583

Human Synonyms: HPE4, TGIF

Human Chr (Location): 18p11.3; chr18:3411927-3458411 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TGIF1

Mutations,
alleles, and
phenotypes
All mutations/alleles(118) : Gene trapped(109) Targeted(9)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display normal growth, behavior and fertility.
 
Human Diseases Modeled in Mice Using Tgif1 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Tgif1 interacts with 132 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process determination of left/right symmetry, dorsal/ventral pattern formation, ...
Component nucleoplasm, nucleus
Function chromatin binding, co-SMAD binding, ...
External Resources: FuncBase
Expression
Literature Summary: (20 records)
Data Summary: Results (240)    Tissues (139)    Images (38)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 144
RT-PCR 96
cDNA source data(173)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase tgif1 ; ZFIN tgif1    NEW 
Molecular
reagents
All nucleic(176) cDNA(173) Primer pair(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000031400 (Evidence)
Ensembl Gene Model ENSMUSG00000047407 (Evidence)
Entrez Gene 21815 (Evidence)
UniGene 101034
DFCI TC1574986, TC1703875, TC1593722, TC1637895
DoTS DT.97414571, DT.101147484, DT.493828, DT.101201822
NIA Mouse Gene Index U038033
Consensus CDS Project CCDS37683.1, CCDS50174.1, CCDS50175.1
International Mouse Phenotyping Consortium Status Tgif1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031400 VEGA Gene Model | MGI Sequence Detail 9342 C57BL/6J ±  kb
transcript OTTMUST00000078088 VEGA | MGI Sequence Detail 1714 Not Applicable 
polypeptide OTTMUSP00000041459 VEGA | MGI Sequence Detail 305 Not Applicable 

For the selected sequences
All sequences(89) RefSeq(16) UniProt(8)
Polymorphisms
SNPs within 2kb(71 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008422 Homeobox KN domain
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
Protein Ontology PR:000016288 homeobox protein TGIF1
References
(Earliest) J:32973 Bertolino E, et al., Expression of a novel murine homeobox gene in the developing cerebellar external granular layer during its proliferation. Dev Dyn. 1996 Apr;205(4):410-20
(Latest) J:220301 Zhang MZ, et al., TGIF Governs a Feed-Forward Network that Empowers Wnt Signaling to Drive Mammary Tumorigenesis. Cancer Cell. 2015 Apr 13;27(4):547-60
All references(73)
Disease annotation references (2)
Other
accession IDs
MGI:2146782, MGI:2146872

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory