Tgif1
Gene Detail

Symbol Name ID

Tgif1 TGFB-induced factor homeobox 1 MGI:1194497

Synonyms

Tgif

Feature Type

protein coding gene

Genetic Map

Chromosome 17

41.87 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr17:70844205-70853546 bp, - strand From VEGA annotation of GRCm38   9342 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7574  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tgif1

Human homologs

Human Homolog		TGIF1, TGFB-induced factor homeobox 1
NCBI Gene ID		7050
neXtProt AC		NX_Q15583
Human Synonyms		HPE4, TGIF
Human Chr (Location)		18p11.3; chr18:3412072-3458409 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TGIF1

Alleles and phenotypes

All alleles(118) : Targeted(9) Gene trapped(109)
 

Homozygous null mice display normal growth, behavior and fertility.

 

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	determination of left/right symmetry, dorsal/ventral pattern formation, ...
Component	nucleus
Function	chromatin binding, co-SMAD binding, ...

External Resources: FuncBase

Expression

Literature Summary: (20 records)
Data Summary: Results (225)    Tissues (109)    Images (27)
Theiler Stages: 2, 3, 4, 5, 11, 13, 16, 17, 21, 22, 23, 26, 28

Assay Type	Results
RNA in situ	122
RT-PCR	103

cDNA source data(201)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(204) cDNA(201) Primer pair(3)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000031400 (Evidence)
Ensembl Gene Model	ENSMUSG00000047407 (Evidence)
Entrez Gene	21815 (Evidence)
UniGene	101034
DFCI	TC1574986, TC1593722, TC1637895, TC1703875
DoTS	DT.101147484, DT.101201822, DT.493828, DT.97414571
NIA Mouse Gene Index	U038033
Consensus CDS Project	CCDS37683.1, CCDS50174.1, CCDS50175.1
International Mouse Knockout Project Status	Tgif1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000031400	VEGA Gene Model | MGI Sequence Detail	9342	C57BL/6J
transcript	OTTMUST00000078088	VEGA | MGI Sequence Detail	1714	Not Applicable
polypeptide	OTTMUSP00000041459	VEGA | MGI Sequence Detail	305	Not Applicable

All sequences(79) RefSeq(10) UniProt(8)

Polymorphisms

SNPs(43 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008422	Homeobox KN domain
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
Protein Ontology	PR:000016288	homeobox protein TGIF1

References

(Earliest) J:32973 Bertolino E, et al., Expression of a novel murine homeobox gene in the developing cerebellar external granular layer during its proliferation. Dev Dyn. 1996 Apr;205(4):410-20
(Latest) J:192644 Hneino M, et al., The TG-interacting factor TGIF1 regulates stress-induced proinflammatory phenotype of endothelial cells. J Biol Chem. 2012 Nov 9;287(46):38913-21
All references(69)

Other accession IDs

MGI:2146782, MGI:2146872