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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Tgif1
TGFB-induced factor homeobox 1
MGI:1194497
36 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Edil3Tg(Sox2-cre)1Amc/Edil3+
Tgif1tm1Caw/Tgif1tm1Caw
Tgif2tm1Dwot/Tgif2tm1Dwot
involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA 		abnormal cephalic neural fold morphology J:183402
abnormal direction of heart looping J:157256
abnormal forebrain development J:183402
abnormal forebrain morphology J:183402
abnormal heart looping J:157256
abnormal left-right axis patterning J:157256
abnormal olfactory epithelium morphology J:183402
abnormal optic vesicle formation J:183402
abnormal primitive streak elongation J:157256
cyclopia J:183402
decreased embryonic neuroepithelial cell proliferation J:183402
decreased embryonic neuroepithelium thickness J:183402
decreased forebrain size J:183402
embryonic lethality during organogenesis, complete penetrance J:157256
embryonic lethality during organogenesis, incomplete penetrance J:183402
failure of heart looping J:157256
heterotaxia J:183402
incomplete rostral neuropore closure J:183402
increased apoptosis J:183402
proboscis J:183402
Gli3tm1Alj/Gli3+
Tgif1tm1Caw/Tgif1tm1Caw
Tgif2tm1Dwot/Tgif2tm1Dwot
Edil3Tg(Sox2-cre)1Amc/Edil3+
involves: 129S6/SvEvTac * 129X1/SvJ * C57BL/6J * CBA 		abnormal cephalic neural fold morphology J:183402
abnormal forebrain development J:183402
abnormal olfactory epithelium morphology J:183402
decreased embryonic neuroepithelial cell proliferation J:183402
exencephaly J:183402
Nodaltm1Rob/Nodal+
Edil3Tg(Sox2-cre)1Amc/Edil3+
Tgif1tm1Caw/Tgif1tm1Caw
Tgif2tm1Dwot/Tgif2tm1Dwot
involves: 129S/SvEv * C57BL/6 * C57BL/6J * CBA 		abnormal embryonic neuroepithelium morphology J:183402
abnormal forebrain development J:183402
abnormal left-right axis patterning J:157256
normal cardiovascular system phenotype J:157256
decreased forebrain size J:183402
embryonic growth retardation J:183402
holoprosencephaly J:183402
rostral body truncation J:183402
Nodaltm1Rob/Nodal+
Tgif1tm1Dwot/Tgif1tm1Dwot
Tgif2tm1Dwot/Tgif2tm1Dwot
involves: 129S/SvEv * 129X1/SvJ * C57BL/6 		normal embryo phenotype J:157256
Tgif1tm1Dwot/Tgif1+
Tgif2tm1Dwot/Tgif2tm1Dwot
involves: 129S/SvEv * 129X1/SvJ * C57BL/6J 		abnormal proximal-distal axis patterning J:157256
decreased body size J:157256
reduced fertility J:157256
Tgif1tm1Dwot/Tgif1tm1Dwot
Tgif2tm1Dwot/Tgif2+
involves: 129S/SvEv * 129X1/SvJ * C57BL/6J 		abnormal proximal-distal axis patterning J:157256
decreased body size J:157256
reduced fertility J:157256
Tgif1tm1Dwot/Tgif1tm1Dwot
Tgif2tm1Dwot/Tgif2tm1Dwot
involves: 129S/SvEv * 129X1/SvJ * C57BL/6J 		abnormal embryonic epiblast morphology J:157256
abnormal gastrulation J:157256
abnormal germ layer development J:157256
abnormal mesoderm development J:157256
abnormal primitive streak elongation J:157256
abnormal proximal-distal axis patterning J:157256
abnormal rostral-caudal axis patterning J:157256
decreased body size J:157256
decreased embryonic epiblast cell proliferation J:157256
embryonic lethality during organogenesis, complete penetrance J:157256
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory