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H3f3b Gene Detail
Summary
  • Symbol
    H3f3b
  • Name
    H3.3 histone B
  • Synonyms
    9430068D06Rik, H3-3b, H3.3B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1101768
    NCBI Gene: 15081
  • Alliance
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:115912738-115918788 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 80.91 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    14 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1101768
protein coding gene Chr11:115912738-115921313 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019410
protein coding gene Chr11:120102778-120111377 (-)
A/J MGP_AJ_G0019379
protein coding gene Chr11:114856180-114857332 (-)
AKR/J MGP_AKRJ_G0019349
protein coding gene Chr11:118283444-118290130 (-)
BALB/cJ MGP_BALBcJ_G0019353
protein coding gene Chr11:115266897-115275497 (-)
C3H/HeJ MGP_C3HHeJ_G0019159
protein coding gene Chr11:118632161-118638078 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019803
protein coding gene Chr11:123768233-123787480 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017426
protein coding gene Chr11:111874008-111879695 (-)
CAST/EiJ MGP_CASTEiJ_G0018714
protein coding gene Chr11:119979379-119986416 (-)
CBA/J MGP_CBAJ_G0019131
protein coding gene Chr11:128669384-128676862 (-)
DBA/2J MGP_DBA2J_G0019242
protein coding gene Chr11:114273348-114279615 (-)
FVB/NJ MGP_FVBNJ_G0019234
protein coding gene Chr11:113784420-113785384 (-)
LP/J MGP_LPJ_G0019312
protein coding gene Chr11:120484573-120491098 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019267
protein coding gene Chr11:127768732-127775364 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019841
protein coding gene Chr11:118938283-118944284 (-)
PWK/PhJ MGP_PWKPhJ_G0018478
protein coding gene Chr11:115606241-115612880 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018271
protein coding gene Chr11:118691925-118699598 (-)
WSB/EiJ MGP_WSBEiJ_G0018766
protein coding gene Chr11:118897320-118904220 (-)



Homology
more
  • Human Ortholog
    H3-3A, H3.3 histone A
  • Vertebrate Orthologs
    9
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    H3-3A, H3.3 histone A
  • Synonyms
    BRYLIB1, H3.3A, H3-3B, H3F3, H3F3A
  • Links
    NCBI Gene ID: 3020
    neXtProt AC: NX_P84243
    UniProt: P84243

  • Chr Location
    1q42.12; chr1:226062707-226072002 (+)  GRCh38.p7

  • Human Ortholog
    H3-3B, H3.3 histone B
  • Synonyms
    BRYLIB2, H3-3A, H3.3B, H3F3B
  • Links
    NCBI Gene ID: 3021
    neXtProt AC: NX_P84243
    UniProt: P84243

  • Chr Location
    17q25.1; chr17:75776434-75779935 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 5 alleles in 5 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice heterozygous for a reporter allele exhibit reduced body size and male infertility due to failure of spermiogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000016559 Ensembl Gene Model | MGI Sequence Detail 6051 C57BL/6J ±  kb
    transcript ENSMUST00000016703 Ensembl | MGI Sequence Detail 1993 Not Applicable  
    polypeptide ENSMUSP00000016703 Ensembl | MGI Sequence Detail 136 Not Applicable  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 61
      cDNA 60
      Primer pair 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1926214
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 9
      Gene Ontology 7
      Phenotypes 17
    • Earliest
      J:42392 Hraba-Renevey S, et al., Expression of a mouse replacement histone H3.3 gene with a highly conserved 3' noncoding region during SV40- and polyoma-induced Go to S-phase transition. Nucleic Acids Res. 1989 Apr 11;17(7):2449-61
    • Latest
      J:318597 Guo P, et al., Histone variant H3.3 maintains adult haematopoietic stem cell homeostasis by enforcing chromatin adaptability. Nat Cell Biol. 2022 Jan;24(1):99-111

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    09/22/2022
    MGI 6.21
    The Jackson Laboratory