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H3f3b Gene Detail
Summary
  • Symbol
    H3f3b
  • Name
    H3 histone, family 3B
  • Synonyms
    9430068D06Rik, H3.3B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1101768
    NCBI Gene: 15081
  • Gene Overview
    MyGene.info: H3F3B
Location & Maps
more
  • Sequence Map
    Chr11:116021912-116027962 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      6051 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 80.91 cM, cytoband E2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    H3F3A, H3 histone, family 3A
  • Vertebrate Orthologs
    17
  • Human Ortholog
    H3F3A, H3 histone, family 3A
    Orthology source: HomoloGene
  • Synonyms
    H3.3A, H3F3
  • Links
    NCBI Gene ID: 3020
    neXtProt AC: NX_P84243

  • Chr Location
    1q42.12; chr1:226062707-226072002 (+)  GRCh38.p2

  • Human Ortholog
    H3F3B, H3 histone, family 3B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    H3.3B
  • Links
    NCBI Gene ID: 3021
    neXtProt AC: NX_P84243

  • Chr Location
    17q25.1; chr17:75776434-75779935 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 4 alleles in 4 genetic backgrounds
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    20
  • Gene trapped
    11
  • Targeted
    9
  • Incidental Mutations
    APF
Mice heterozygous for a reporter allele exhibit reduced body size and male infertility due to failure of spermiogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003689 VEGA Gene Model | MGI Sequence Detail 6051 C57BL/6J ±  kb
transcript OTTMUST00000007997 VEGA | MGI Sequence Detail 2514 Not Applicable  
polypeptide OTTMUSP00000003888 VEGA | MGI Sequence Detail 136 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    26 from dbSNP Build 142
Molecular
Reagents
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  • All nucleic 60
    cDNA 59
    Primer pair 1

    Microarray probesets 5
Other
Accession IDs
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MGI:1926214
References
more
  • Summaries
    All 41
    Developmental Gene Expression 7
    Gene Ontology 7
    Phenotypes 11
  • Earliest
    J:42392 Hraba-Renevey S, et al., Expression of a mouse replacement histone H3.3 gene with a highly conserved 3' noncoding region during SV40- and polyoma-induced Go to S-phase transition. Nucleic Acids Res. 1989 Apr 11;17(7):2449-61
  • Latest
    J:225909 Jang CW, et al., Histone H3.3 maintains genome integrity during mammalian development. Genes Dev. 2015 Jul 1;29(13):1377-92

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory