About   Help   FAQ
H3f3b Gene Detail
Summary
  • Symbol
    H3f3b
  • Name
    H3.3 histone B
  • Synonyms
    9430068D06Rik, H3-3b, H3.3B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1101768
    NCBI Gene: 15081
  • Alliance
    genome feature page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:115912738-115918788 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 80.91 cM, cytoband E2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    176 from dbSNP Build 142
  • Strain Annotations
    11
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1101768
 protein coding gene Chr11:115912738-115921313 (-)
129S1/SvImJ ENSMUSG00200048530
 protein coding gene Chr11:113279083-113285120 (-)
A/J no annotation
AKR/J no annotation
BALB/cJ ENSMUSG00180050307
 protein coding gene Chr11:113280510-113286552 (-)
C3H/HeJ no annotation
C57BL/6NJ no annotation
CAROLI/EiJ MGP_CAROLIEiJ_G0017426
 protein coding gene Chr11:111874008-111879695 (-)
CAST/EiJ ENSTCUG00005030628
 protein coding gene Chr11:112641612-112647545 (-)
CBA/J no annotation
DBA/2J ENSMUSG00185023933
 protein coding gene Chr11:113272020-113278062 (-)
FVB/NJ ENSMUSG00205034196
 protein coding gene Chr11:113077801-113083837 (-)
JF1/MsJ ENSUMUG00000050980
 protein coding gene Chr11:113540314-113546176 (-)
LP/J no annotation
NOD/ShiLtJ ENSMUSG00190042724
 protein coding gene Chr11:113303508-113309545 (-)
NZO/HlLtJ no annotation
PWK/PhJ ENSLUMG00010023174
 protein coding gene Chr11:113060169-113066030 (-)
SPRET/EiJ no annotation
WSB/EiJ ENSIUOG00005046328
 protein coding gene Chr11:113044859-113050693 (-)



Homology
more
  • Human Ortholog
    H3-3B, H3.3 histone B
  • Vertebrate Orthologs
    9
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    H3-3B, H3.3 histone B
  • Synonyms
    BRYLIB2, H3.3B, H3F3B
  • Links
    NCBI Gene ID: 3021
    UniProt: P84243

  • Chr Location
    17q25.1; chr17:75776434-75785893 (-)  GRCh38
  • Human Ortholog
    H3-5, H3.5 histone
  • Synonyms
    H3.3C, H3.5, H3F3C
  • Links
    NCBI Gene ID: 440093
    UniProt: Q6NXT2

  • Chr Location
    12p11.21; chr12:31791185-31792298 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human H3-3A,H3-3B associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    15 phenotypes from 5 alleles in 5 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice heterozygous for a reporter allele exhibit reduced body size and male infertility due to failure of spermiogenesis.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    751
  • Tissues
    57
  • cDNA Data
    59
  • Literature Summary
    9
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000016559 Ensembl Gene Model | MGI Sequence Detail 6051 C57BL/6J ±  kb
    transcript ENSMUST00000106454 Ensembl | MGI Sequence Detail 2514 Not Applicable  
    polypeptide ENSMUSP00000102062 Ensembl | MGI Sequence Detail 136 Not Applicable  
    For the selected sequence
    Molecular
    Reagents
    less
    • All nucleic 63
      cDNA 60
      Primer pair 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1926214
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 9
      Phenotypes 18
    • Earliest
      J:42392 Hraba-Renevey S, et al., Expression of a mouse replacement histone H3.3 gene with a highly conserved 3' noncoding region during SV40- and polyoma-induced Go to S-phase transition. Nucleic Acids Res. 1989 Apr 11;17(7):2449-61
    • Latest
      J:390413 Chauhan S, et al., Histone H3.3 ensures cell proliferation and genomic stability during myeloid cell development. iScience. 2026 Jul 17;29(7):116501
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    09/08/2026
    MGI 6.24     		The Jackson Laboratory