Ltbp3
Gene Detail

Symbol Name ID

Ltbp3 latent transforming growth factor beta binding protein 3 MGI:1101355

Synonyms

Ltbp2

Feature Type

protein coding gene

Genetic Map

Chromosome 19

4.34 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr19:5740904-5758532 bp, + strand From NCBI annotation of GRCm38   17629 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7405  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Ltbp3

Human homologs

Human Homolog		LTBP3, latent transforming growth factor beta binding protein 3
NCBI Gene ID		4054
neXtProt AC		NX_Q9NS15
Human Synonyms		LTBP2, LTBP-3, pp6425, STHAG6
Human Chr (Location)		11q13.1; chr11:65306030-65325699 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human LTBP3

Alleles and phenotypes

All alleles(6) : Targeted(2) Gene trapped(3) Chemically induced(1)
 

Homozygotes for a targeted null mutation exhibit craniofacial malformations including an overshot mandible and ossification of synchondroses. Mutants develop osteosclerosis of long bones and osteoarthritis, and, in some cases, high corticosterone levels.

 
Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	bone morphogenesis, bone remodeling, ...
Component	extracellular region, proteinaceous extracellular matrix
Function	calcium ion binding, growth factor binding

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (344)    Tissues (133)    Images (51)
Theiler Stages: 13, 14, 17, 19, 20, 21, 22, 23, 24, 28

Assay Type	Results
RNA in situ	344

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(27) Genomic(2) cDNA(21) Primer pair(3) Other(1)
Microarray probesets(7)

Other database links

Ensembl Gene Model	ENSMUSG00000024940 (Evidence)
Entrez Gene	16998 (Evidence)
NIA Mouse Gene Index	U038709
Consensus CDS Project	CCDS37891.1
International Mouse Knockout Project Status	Ltbp3

Sequences

Length	Strain/Species
genomic	16998	NCBI Gene Model | MGI Sequence Detail	17629	C57BL/6J
transcript	NM_008520	RefSeq | MGI Sequence Detail	5209	C57BL/6
polypeptide	Q61810	UniProt | EBI | MGI Sequence Detail	1268	Not Applicable

All sequences(24) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(46 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR017878	TB domain
Protein Ontology	PR:000009974	latent-transforming growth factor beta-binding protein 3

Graphical View of Protein Domain Structure

References

(Earliest) J:22443 Li X, et al., Mapping of human and murine genes for latent TGF-beta binding protein-2 (LTBP2). Mamm Genome. 1995 Jan;6(1):42-5
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(44)