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Symbol
Name
ID

Ltbp3
latent transforming growth factor beta binding protein 3
MGI:1101355

Phenotype annotations related to skeleton

Darker colors indicate more annotations

Human Phenotypes

Mandibular prognathia

Hypoplasia of the maxilla

Amelogenesis imperfecta

Brachydactyly

Short foot

Limited elbow movement

Limited wrist movement

Limb undergrowth

Delayed skeletal maturation

Epiphyseal dysplasia

Scoliosis

Herniation of intervertebral nuclei

Intervertebral space narrowing

Platyspondyly

Narrow vertebral interpedicular distance

Disease(s) Associated with LTBP3

brachyolmia-amelogenesis imperfecta syndrome

geleophysic dysplasia 3

Mouse Phenotypes

abnormal craniofacial bone morphology

abnormal cranium morphology

abnormal basicranium morphology

abnormal basioccipital bone morphology

abnormal basisphenoid bone morphology

abnormal foramen magnum morphology

short basicranium

abnormal neurocranium morphology

abnormal frontal bone morphology

occipital bossing

round orbits

misaligned incisors

abnormal enamel organ morphology

abnormal enamel morphology

reduced enamel thickness

malocclusion

short maxilla

prognathia

domed cranium

ectopic cranial bone

osteoarthritis

abnormal long bone epiphyseal plate proliferative zone

increased width of hypertrophic chondrocyte zone

abnormal long bone metaphysis morphology

decreased length of long bones

abnormal thoracic cage shape

abnormal thoracic vertebrae morphology

kyphosis

abnormal cervical vertebrae morphology

abnormal trabecular bone morphology

increased trabecular bone mass

osteosclerosis

abnormal synchondrosis

abnormal joint morphology

premature bone ossification

abnormal bone remodeling

Availability

Mouse Genotype

Ltbp3^blfc/Ltbp3^blfc

Ltbp3^m1Btlr/Ltbp3^m1Btlr

Ltbp3^tm1Bdvc/Ltbp3^tm1Bdvc

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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