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Celsr1
Gene Detail
Symbol

Name
ID
Celsr1
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
MGI:1100883
Synonyms
Adgrc1, crash, Crsh, Scy
Feature Type
protein coding gene
Genetic Map
Chromosome 15
40.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:85898758-86033777 bp, - strand
From Ensembl annotation of GRCm38

  135020 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7665  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: CELSR1
Protein SuperFamily: cadherin EGF LAG seven-pass G-type receptor
Gene Tree: Celsr1

Human
homologs
CELSR1, cadherin, EGF LAG seven-pass G-type receptor 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9620
neXtProt AC: NX_Q9NYQ6

Human Synonyms: ADGRC1, CDHF9, FMI2, HFMI2, ME2

Human Chr (Location): 22q13.3; chr22:46360834-46537502 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Chemically induced (ENU)(2) Radiation induced(1) Targeted(7)
Genomic Mutations involving Celsr1 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
Phenotype Images(2)
Interactions
Celsr1 interacts with 273 markers (Mir1b, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (22 records)
Data Summary: Results (66)    Tissues (53)    Images (33)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 60
cDNA source data(56)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase celsr1 ; ZFIN celsr1a, celsr1b    NEW 
Molecular
reagents
All nucleic(59) Genomic(1) cDNA(56) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000016028 (Evidence)
Entrez Gene 12614 (Evidence)
UniGene 22680
DFCI TC1582428, TC1728474, TC1775431
DoTS DT.485096, DT.94012385, DT.94012391
NIA Mouse Gene Index U036504
Consensus CDS Project CCDS37172.1
International Mouse Phenotyping Consortium Status Celsr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000016028 Ensembl Gene Model | MGI Sequence Detail 135020 C57BL/6J ±  kb
transcript ENSMUST00000016172 Ensembl | MGI Sequence Detail 11050 Not Applicable 
polypeptide ENSMUSP00000016172 Ensembl | MGI Sequence Detail 3034 Not Applicable 

For the selected sequences
All sequences(32) RefSeq(13) UniProt(2)
Polymorphisms
RFLP(4) : SNPs within 2kb(1880 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002126 Cadherin
InterPro IPR020894 Cadherin conserved site
InterPro IPR015919 Cadherin-like
InterPro IPR013320 Concanavalin A-like lectin/glucanase domain
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 EGF-like domain
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR000203 GPS motif
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR002049 Laminin EGF domain
InterPro IPR001791 Laminin G domain
Protein Ontology PR:000005318 cadherin EGF LAG seven-pass G-type receptor 1
References
(Earliest) J:43499 Hadjantonakis AK, et al., Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter. Genomics. 1997 Oct 1;45(1):97-104
(Latest) J:222308 Fairfield H, et al., Exome sequencing reveals pathogenic mutations in 91 strains of mice with Mendelian disorders. Genome Res. 2015 Jul;25(7):948-57
All references(56)
Other
accession IDs
MGI:1861995, MGI:2387968

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory