Celsr1
Gene Detail

Symbol Name ID

Celsr1 cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila) MGI:1100883

Synonyms

crash, Crsh, Scy

Feature Type

protein coding gene

Genetic Map

Chromosome 15

40.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr15:85898758-86033777 bp, - strand From NCBI annotation of GRCm38   135020 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7665  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: cadherin EGF LAG seven-pass G-type receptor
Gene Tree: Celsr1

Human homologs

Human Homolog		CELSR1, cadherin, EGF LAG seven-pass G-type receptor 1
NCBI Gene ID		9620
neXtProt AC		NX_Q9NYQ6
Human Synonyms		CDHF9, FMI2, HFMI2, ME2
Human Chr (Location)		22q13.3; chr22:46756731-46933067 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(7) : Targeted(5) Chemically induced(2)
 

Both heterozygous and homozygous mutant mice show an inner ear defect characterized by the disorganization of hair cells. Additionally, homozygous mutant mice exhibit severe neural tube defects and impaired lung branching morphogenesis.

 

Gene Ontology (GO) classifications

All GO classifications: (44 annotations)

Process	anterior/posterior pattern specification, apical protein localization, ...
Component	integral to membrane, integral to plasma membrane, ...
Function	calcium ion binding, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (18 records)
Data Summary: Results (66)    Tissues (53)    Images (33)
Theiler Stages: 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 20, 21, 23, 26, 28

Assay Type	Results
Immunohistochemistry	6
RNA in situ	60

cDNA source data(56)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(59) Genomic(1) cDNA(56) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000016028 (Evidence)
Entrez Gene	12614 (Evidence)
UniGene	22680
DFCI	TC1582428, TC1728474, TC1775431
DoTS	DT.485096, DT.94012385, DT.94012391
NIA Mouse Gene Index	U036504
Consensus CDS Project	CCDS37172.1
International Mouse Knockout Project Status	Celsr1

Sequences

Length	Strain/Species
genomic	12614	NCBI Gene Model | MGI Sequence Detail	135020	C57BL/6J
transcript	NM_009886	RefSeq | MGI Sequence Detail	11050	C57BL/6
polypeptide	O35161	UniProt | EBI | MGI Sequence Detail	3034	Not Applicable

All sequences(21) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(4) : SNPs(1069 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002126	Cadherin
InterPro	IPR020894	Cadherin conserved site
InterPro	IPR015919	Cadherin-like
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR013320	Concanavalin A-like lectin/glucanase, subgroup
InterPro	IPR022624	Domain of unknown function DUF3497
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR002049	EGF-like, laminin
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR001879	GPCR, family 2, extracellular hormone receptor domain
InterPro	IPR017981	GPCR, family 2-like
InterPro	IPR000832	GPCR, family 2, secretin-like
InterPro	IPR000203	GPS domain
InterPro	IPR001791	Laminin G domain
Protein Ontology	PR:000005318	cadherin EGF LAG seven-pass G-type receptor 1

Graphical View of Protein Domain Structure

References

(Earliest) J:43499 Hadjantonakis AK, et al., Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter. Genomics. 1997 Oct 1;45(1):97-104
(Latest) J:194042 Mahaffey JP, et al., Cofilin and Vangl2 cooperate in the initiation of planar cell polarity in the mouse embryo. Development. 2013 Mar;140(6):1262-71
All references(46)

Other accession IDs

MGI:1861995, MGI:2387968