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Celsr1
Gene Detail
 Symbol
Name
ID
Celsr1
cadherin, EGF LAG seven-pass G-type receptor 1 (flamingo homolog, Drosophila)
MGI:1100883
Synonyms crash, Crsh, Scy
Feature Type protein coding gene
Genetic Map
Chromosome 15
40.42 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr15:85898758-86033777 bp, - strand
From NCBI annotation of GRCm38

  135020 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7665  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: cadherin EGF LAG seven-pass G-type receptor
Gene Tree: Celsr1

Human
homologs
Human Homolog CELSR1, cadherin, EGF LAG seven-pass G-type receptor 1
NCBI Gene ID 9620
neXtProt AC  NX_Q9NYQ6
Human Synonyms  CDHF9, FMI2, HFMI2, ME2
Human Chr (Location)  22q13.3; chr22:46360834-46537170 (-)  GRCh38
Alleles
and
phenotypes
All alleles(8) : Targeted(6) Chemically induced(2)
 
Both heterozygous and homozygous mutant mice show an inner ear defect characterized by the disorganization of hair cells. Additionally, homozygous mutant mice exhibit severe neural tube defects and impaired lung branching morphogenesis.
 
Gene Ontology
(GO)
classifications
All GO classifications: (46 annotations)
Process anterior/posterior pattern specification, apical protein localization, ...
Component integral component of membrane, integral component of plasma membrane, ...
Function calcium ion binding, G-protein coupled receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (18 records)
Data Summary: Results (66)    Tissues (53)    Images (33)
Theiler Stages: 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 20, 21, 23, 26, 28
Assay TypeResults
Immunohistochemistry 6
RNA in situ 60
cDNA source data(56)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(59) Genomic(1) cDNA(56) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000016028 (Evidence)
Entrez Gene12614 (Evidence)
UniGene22680
DFCITC1582428, TC1728474, TC1775431
DoTSDT.485096, DT.94012385, DT.94012391
NIA Mouse Gene IndexU036504
Consensus CDS ProjectCCDS37172.1
International Mouse Knockout Project StatusCelsr1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 12614 NCBI Gene Model | MGI Sequence Detail 135020 C57BL/6J ±  kb
transcript NM_009886 RefSeq | MGI Sequence Detail 11050 C57BL/6 
polypeptide O35161 UniProt | EBI | MGI Sequence Detail 3034 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(10) UniProt(2)
Polymorphisms RFLP(4) : SNPs within 2kb(1880 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002126 Cadherin
InterPro IPR020894 Cadherin conserved site
InterPro IPR015919 Cadherin-like
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR022624 Domain of unknown function DUF3497
InterPro IPR013032 EGF-like, conserved site
InterPro IPR002049 EGF-like, laminin
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR001879 GPCR, family 2, extracellular hormone receptor domain
InterPro IPR017981 GPCR, family 2-like
InterPro IPR000832 GPCR, family 2, secretin-like
InterPro IPR000203 GPS domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR001791 Laminin G domain
Protein Ontology PR:000005318 cadherin EGF LAG seven-pass G-type receptor 1
Graphical View of Protein Domain Structure
References (Earliest) J:43499 Hadjantonakis AK, et al., Celsr1, a neural-specific gene encoding an unusual seven-pass transmembrane receptor, maps to mouse chromosome 15 and human chromosome 22qter. Genomics. 1997 Oct 1;45(1):97-104
(Latest) J:201287 Hermle T, et al., Drosophila ATP6AP2/VhaPRR functions both as a novel planar cell polarity core protein and a regulator of endosomal trafficking. EMBO J. 2013 Jan 23;32(2):245-59
All references(49)
Other
accession IDs
MGI:1861995, MGI:2387968

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory