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Prss12
Gene Detail
Symbol

Name
ID
Prss12
protease, serine 12 neurotrypsin (motopsin)
MGI:1100881
Synonyms
Bssp-3, motopsin
Feature Type
protein coding gene
Genetic Map
Chromosome 3
54.58 cM, cytoband G3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:123446913-123506597 bp, + strand
From VEGA annotation of GRCm38

  59685 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7490  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PRSS12
Protein SuperFamily: neurotrypsin
Gene Tree: Prss12

Human
homologs
PRSS12, protease, serine, 12 (neurotrypsin, motopsin)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8492
neXtProt AC: NX_P56730

Human Synonyms: BSSP3, BSSP-3, MRT1

Human Chr (Location): 4q28.1; chr4:118280038-118352815 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PRSS12

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a targeted mutation display hypoactivity and increased anxiety.
 
Interactions
Prss12 interacts with 16 markers (Mir146, Mir190b, Mir218-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (20 annotations)
Process exocytosis, proteolysis, ...
Component axon, cytoplasmic vesicle, ...
Function hydrolase activity, peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (147)    Tissues (64)    Images (42)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 53
In situ reporter (knock in) 42
Western blot 14
RT-PCR 38
cDNA source data(19)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(19) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000052551 (Evidence)
Ensembl Gene Model ENSMUSG00000027978 (Evidence)
Entrez Gene 19142 (Evidence)
UniGene 9431
DFCI TC1583499
DoTS DT.485604
NIA Mouse Gene Index U003815
EC 3.4.21.-
Consensus CDS Project CCDS17817.1
International Mouse Phenotyping Consortium Status Prss12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052551 VEGA Gene Model | MGI Sequence Detail 59685 C57BL/6J ±  kb
transcript OTTMUST00000131751 VEGA | MGI Sequence Detail 2602 Not Applicable 
polypeptide OTTMUSP00000070384 VEGA | MGI Sequence Detail 761 Not Applicable 

For the selected sequences
All sequences(21) RefSeq(2) UniProt(1)
Polymorphisms
SNPs within 2kb(743 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000001 Kringle
InterPro IPR018056 Kringle, conserved site
InterPro IPR013806 Kringle-like fold
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR009003 Peptidase S1, PA clan
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR001254 Serine proteases, trypsin domain
InterPro IPR001190 SRCR domain
InterPro IPR017448 SRCR-like domain
Protein Ontology PR:000013319 neurotrypsin
References
(Earliest) J:43684 Yamamura Y, et al., Molecular cloning of a novel brain-specific serine protease with a kringle-like structure and three scavenger receptor cysteine-rich motifs. Biochem Biophys Res Commun. 1997 Oct 20;239(2):386-92
(Latest) J:209333 Almenar-Queralt A, et al., Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation. J Biol Chem. 2013 Dec 6;288(49):35222-36
All references(39)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory