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Prss12 Gene Detail
Summary
  • Symbol
    Prss12
  • Name
    protease, serine 12 neurotrypsin (motopsin)
  • Synonyms
    Bssp-3, motopsin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100881
    NCBI Gene: 19142
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:123446913-123506597 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 54.58 cM, cytoband G3
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    716 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100881
protein coding gene Chr3:123446913-123506602 (.)
129S1/SvImJ MGP_129S1SvImJ_G0027850
protein coding gene Chr3:125757132-125814373 (+)
A/J MGP_AJ_G0027809
protein coding gene Chr3:121547398-121603588 (+)
AKR/J MGP_AKRJ_G0027774
protein coding gene Chr3:124648911-124707027 (+)
BALB/cJ MGP_BALBcJ_G0027821
protein coding gene Chr3:121357672-121411508 (+)
C3H/HeJ MGP_C3HHeJ_G0027551
protein coding gene Chr3:125045348-125101219 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028266
protein coding gene Chr3:130310175-130373817 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025603
protein coding gene Chr3:116966390-117021681 (+)
CAST/EiJ MGP_CASTEiJ_G0027006
protein coding gene Chr3:124461738-124520519 (+)
CBA/J MGP_CBAJ_G0027526
protein coding gene Chr3:134711221-134773386 (+)
DBA/2J MGP_DBA2J_G0027667
protein coding gene Chr3:120679029-120734629 (+)
FVB/NJ MGP_FVBNJ_G0027635
protein coding gene Chr3:118299475-118355901 (+)
LP/J MGP_LPJ_G0027777
protein coding gene Chr3:127291289-127355296 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027665
protein coding gene Chr3:142291164-142350629 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028322
protein coding gene Chr3:124217795-124277360 (+)
PWK/PhJ MGP_PWKPhJ_G0026732
protein coding gene Chr3:120423086-120479152 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026556
protein coding gene Chr3:122324428-122388211 (+)
WSB/EiJ MGP_WSBEiJ_G0027086
protein coding gene Chr3:124968666-125029082 (+)



Homology
more
  • Human Ortholog
    PRSS12, serine protease 12
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRSS12, serine protease 12
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BSSP3, BSSP-3, MRT1
  • Links
    NCBI Gene ID: 8492
    neXtProt AC: NX_P56730
    UniProt: P56730

  • Chr Location
    4q26; chr4:118280038-118353042 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human PRSS12 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted mutation display hypoactivity and increased anxiety.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000027978 Ensembl Gene Model | MGI Sequence Detail 59685 C57BL/6J ±  kb
transcript ENSMUST00000029603 Ensembl | MGI Sequence Detail 2602 Not Applicable  
polypeptide ENSMUSP00000029603 Ensembl | MGI Sequence Detail 761 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    cDNA 20
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 46
    Developmental Gene Expression 11
    Diseases 1
    Gene Ontology 8
    Phenotypes 13
  • Earliest
    J:43684 Yamamura Y, et al., Molecular cloning of a novel brain-specific serine protease with a kringle-like structure and three scavenger receptor cysteine-rich motifs. Biochem Biophys Res Commun. 1997 Oct 20;239(2):386-92
  • Latest
    J:259548 Reinhard JR, et al., Linker proteins restore basement membrane and correct LAMA2-related muscular dystrophy in mice. Sci Transl Med. 2017 Jun 28;9(396)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/11/2018
MGI 6.13
The Jackson Laboratory