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Prss12
Gene Detail
 Symbol
Name
ID
Prss12
protease, serine 12 neurotrypsin (motopsin)
MGI:1100881
Synonyms Bssp-3, motopsin
Feature Type protein coding gene
Genetic Map
Chromosome 3
54.58 cM, cytoband G3
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr3:123446913-123506602 bp, + strand
From NCBI annotation of GRCm38

  59690 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7490  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: neurotrypsin
Gene Tree: Prss12

Human
homologs
Human Homolog PRSS12, protease, serine, 12 (neurotrypsin, motopsin)
NCBI Gene ID 8492
neXtProt AC  NX_P56730
Human Synonyms  BSSP3, BSSP-3, MRT1
Human Chr (Location)  4q28.1; chr4:118280038-118352896 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human PRSS12
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation display hypoactivity and increased anxiety.
 
Interactions
Prss12 interacts with 16 markers (Mir146, Mir190b, Mir218-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process exocytosis, proteolysis, ...
Component axon, cytoplasmic vesicle, ...
Function catalytic activity, hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (147)    Tissues (63)    Images (42)
Theiler Stages: 23, 24, 26, 28
Assay TypeResults
RNA in situ 53
In situ reporter (knock in) 42
Western blot 14
RT-PCR 38
cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(20) cDNA(19) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000027978 (Evidence)
Entrez Gene19142 (Evidence)
UniGene9431
DFCITC1583499
DoTSDT.485604
NIA Mouse Gene IndexU003815
EC3.4.21.-
Consensus CDS ProjectCCDS17817.1
International Mouse Knockout Project StatusPrss12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19142 NCBI Gene Model | MGI Sequence Detail 59690 C57BL/6J ±  kb
transcript NM_008939 RefSeq | MGI Sequence Detail 2607 C57BL/6 
polypeptide O08762 UniProt | EBI | MGI Sequence Detail 761 Not Applicable 

For the selected sequences
All sequences(17) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(743 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000001 Kringle
InterPro IPR018056 Kringle, conserved site
InterPro IPR013806 Kringle-like fold
InterPro IPR001254 Peptidase S1
InterPro IPR001314 Peptidase S1A, chymotrypsin-type
InterPro IPR018114 Peptidase S1, trypsin family, active site
InterPro IPR001190 Speract/scavenger receptor
InterPro IPR017448 Speract/scavenger receptor-related
InterPro IPR009003 Trypsin-like cysteine/serine peptidase domain
Protein Ontology PR:000013319 neurotrypsin
Graphical View of Protein Domain Structure
References (Earliest) J:43684 Yamamura Y, et al., Molecular cloning of a novel brain-specific serine protease with a kringle-like structure and three scavenger receptor cysteine-rich motifs. Biochem Biophys Res Commun. 1997 Oct 20;239(2):386-92
(Latest) J:198977 Gisler C, et al., Zymogen activation of neurotrypsin and neurotrypsin-dependent agrin cleavage on the cell surface are enhanced by glycosaminoglycans. Biochem J. 2013 Jul 1;453(1):83-100
All references(39)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory