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Prss12 Gene Detail
Summary
  • Symbol
    Prss12
  • Name
    protease, serine 12 neurotrypsin (motopsin)
  • Synonyms
    Bssp-3, motopsin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100881
    NCBI Gene: 19142
Location & Maps
more
  • Sequence Map
    Chr3:123446913-123506597 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      59685 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 54.58 cM, cytoband G3
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    PRSS12, protease, serine 12
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRSS12, protease, serine 12
    Orthology source: HGNC, HomoloGene
  • Synonyms
    BSSP3, BSSP-3, MRT1
  • Links
    NCBI Gene ID: 8492
    neXtProt AC: NX_P56730

  • Chr Location
    4q28.1; chr4:118280038-118352815 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human PRSS12 associations

Human Disease Mouse Models
       Mental Retardation, Autosomal Recessive 1; MRT1   OMIM: 249500
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Radiation induced
    1
  • Targeted
    6
  • Transgenic
    2
  • Genomic Mutations
    2 involving Prss12
  • Incidental Mutations
Mice homozygous for a targeted mutation display hypoactivity and increased anxiety.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000052551 VEGA Gene Model | MGI Sequence Detail 59685 C57BL/6J ±  kb
transcript OTTMUST00000131751 VEGA | MGI Sequence Detail 2602 Not Applicable  
polypeptide OTTMUSP00000070384 VEGA | MGI Sequence Detail 761 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    716 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 20
    cDNA 19
    Primer pair 1

    Microarray probesets 3
References
more
  • Summaries
    All 36
    Developmental Gene Expression 10
    Gene Ontology 6
    Phenotypes 12
  • Earliest
    J:43684 Yamamura Y, et al., Molecular cloning of a novel brain-specific serine protease with a kringle-like structure and three scavenger receptor cysteine-rich motifs. Biochem Biophys Res Commun. 1997 Oct 20;239(2):386-92
  • Latest
    J:209333 Almenar-Queralt A, et al., Presenilins regulate neurotrypsin gene expression and neurotrypsin-dependent agrin cleavage via cyclic AMP response element-binding protein (CREB) modulation. J Biol Chem. 2013 Dec 6;288(49):35222-36

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory