Prss12
Gene Detail

Symbol Name ID

Prss12 protease, serine, 12 neurotrypsin (motopsin) MGI:1100881

Synonyms

Bssp-3, motopsin

Feature Type

protein coding gene

Genetic Map

Chromosome 3

54.58 cM, cytoband G3
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr3:123446913-123506602 bp, + strand From NCBI annotation of GRCm38   59690 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Prss12 ± 2 cM)

Protein SuperFamily: neurotrypsin
Gene Tree: Prss12

Human ortholog

PRSS12 protease, serine, 12 (neurotrypsin, motopsin) NCBI Gene ID 8492
Human Synonyms: BSSP3, BSSP-3, MRT1
Human Chr4:119201193-119273922 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human PRSS12 (1)

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Mice homozygous for a targeted mutation display hypoactivity and increased anxiety.

 

Gene Ontology (GO) classifications

All GO classifications: (18 annotations)

Process	proteolysis, zymogen activation
Component	cytoplasmic vesicle, dendrite, ...
Function	catalytic activity, hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (147)    Tissues (63)    Images (42)
Theiler Stages: 23, 24, 26, 28

Assay Type	Results
RNA in situ	53
In situ reporter (knock in)	42
Western blot	14
RT-PCR	38

cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(20) cDNA(19) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000027978 (Evidence)
Entrez Gene	19142 (Evidence)
UniGene	9431
DFCI	TC1583499
DoTS	DT.485604
NIA Mouse Gene Index	U003815
EC	3.4.21.-
Consensus CDS Project	CCDS17817.1
International Mouse Knockout Project Status	Prss12

Sequences

Length	Strain/Species
genomic	19142	NCBI Gene Model | MGI Sequence Detail	59690	C57BL/6J
transcript	NM_008939	RefSeq | MGI Sequence Detail	2607	C57BL/6
polypeptide	O08762	UniProt | EBI | MGI Sequence Detail	761	Not Applicable

All sequences(17) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(528 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000001	Kringle
InterPro	IPR018056	Kringle, conserved site
InterPro	IPR013806	Kringle-like fold
InterPro	IPR009003	Peptidase cysteine/serine, trypsin-like
InterPro	IPR001314	Peptidase S1A, chymotrypsin-type
InterPro	IPR001254	Peptidase S1/S6, chymotrypsin/Hap
InterPro	IPR018114	Peptidase S1/S6, chymotrypsin/Hap, active site
InterPro	IPR001190	Speract/scavenger receptor
InterPro	IPR017448	Speract/scavenger receptor-related
Protein Ontology	PR:000013319	neurotrypsin

Graphical View of Protein Domain Structure

References

(Earliest) J:43684 Yamamura Y, et al., Molecular cloning of a novel brain-specific serine protease with a kringle-like structure and three scavenger receptor cysteine-rich motifs. Biochem Biophys Res Commun. 1997 Oct 20;239(2):386-92
(Latest) J:178376 Butikofer L, et al., Destabilization of the neuromuscular junction by proteolytic cleavage of agrin results in precocious sarcopenia. FASEB J. 2011 Dec;25(12):4378-93
All references(37)