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Smad7 Gene Detail
Summary
  • Symbol
    Smad7
  • Name
    SMAD family member 7
  • Synonyms
    Madh7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100518
    NCBI Gene: 17131
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:75367529-75395935 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 51.06 cM, cytoband E2
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    165 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1100518
protein coding gene Chr18:75367365-75395935 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024564
protein coding gene Chr18:76069192-76097824 (+)
A/J MGP_AJ_G0024531
protein coding gene Chr18:72741649-72770149 (+)
AKR/J MGP_AKRJ_G0024502
protein coding gene Chr18:74921037-74949367 (+)
BALB/cJ MGP_BALBcJ_G0024531
protein coding gene Chr18:72939702-72968785 (+)
C3H/HeJ MGP_C3HHeJ_G0024299
protein coding gene Chr18:75006579-75036636 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024977
protein coding gene Chr18:78057233-78085754 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022407
protein coding gene Chr18:71796423-71825414 (+)
CAST/EiJ MGP_CASTEiJ_G0023772
protein coding gene Chr18:75209666-75238594 (+)
CBA/J MGP_CBAJ_G0024268
protein coding gene Chr18:80761594-80792206 (+)
DBA/2J MGP_DBA2J_G0024398
protein coding gene Chr18:72327493-72356012 (+)
FVB/NJ MGP_FVBNJ_G0024364
protein coding gene Chr18:71675743-71704381 (+)
LP/J MGP_LPJ_G0024482
protein coding gene Chr18:75934388-75966040 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024394
protein coding gene Chr18:82163603-82193115 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025025
protein coding gene Chr18:75040154-75068607 (+)
PWK/PhJ MGP_PWKPhJ_G0023516
protein coding gene Chr18:72719719-72749548 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023320
protein coding gene Chr18:75191009-75220263 (+)
WSB/EiJ MGP_WSBEiJ_G0023835
protein coding gene Chr18:74983710-75015169 (+)



Homology
more
  • Human Ortholog
    SMAD7, SMAD family member 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SMAD7, SMAD family member 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CRCS3, MADH7, MADH8
  • Links
    NCBI Gene ID: 4092
    neXtProt AC: NX_O15105
    UniProt: O15105

  • Chr Location
    18q21.1; chr18:48919853-48950711 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human SMAD7 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    49 phenotypes from 9 alleles in 10 genetic backgrounds
    6 phenotypes from multigenic genotypes
    4 images
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a hypomorphic allele display partial penetrance of prenatal lethality, reduced body size and weight, smaller litter size and B cell abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025880 Ensembl Gene Model | MGI Sequence Detail 28407 C57BL/6J ±  kb
    transcript ENSMUST00000168918 Ensembl | MGI Sequence Detail 1882 Not Applicable  
    polypeptide ENSMUSP00000129322 Ensembl | MGI Sequence Detail 426 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      cDNA 34
      Primer pair 4
      Other 3

      Microarray probesets 3
    References
    more
    • Summaries
      All 169
      Developmental Gene Expression 43
      Gene Ontology 16
      Phenotypes 35
    • Earliest
      J:43278 Nakao A, et al., Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling [see comments]. Nature. 1997 Oct 9;389(6651):631-5
    • Latest
      J:261006 Li X, et al., MicroRNA-21 promotes wound healing via the Smad7-Smad2/3-Elastin pathway. Exp Cell Res. 2018 Jan 15;362(2):245-251

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory