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Smad7 Gene Detail
Summary
  • Symbol
    Smad7
  • Name
    SMAD family member 7
  • Synonyms
    Madh7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100518
    NCBI Gene: 17131
Location & Maps
more
  • Sequence Map
    Chr18:75367529-75395935 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      28407 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 51.06 cM, cytoband E2
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    SMAD7, SMAD family member 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SMAD7, SMAD family member 7
    Orthology source: HomoloGene
  • Synonyms
    CRCS3, MADH7, MADH8
  • Links
    NCBI Gene ID: 4092
    neXtProt AC: NX_O15105

  • Chr Location
    18q21.1; chr18:48919853-48950711 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human SMAD7 associations

Human Disease Mouse Models
       Colorectal Cancer, Susceptibility to, 3; CRCS3   OMIM: 612229
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    49 phenotypes from 9 alleles in 10 genetic backgrounds
    6 phenotypes from multigenic genotypes
    4 images
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    88
  • Gene trapped
    78
  • Targeted
    8
  • Transgenic
    1
  • Transposon induced
    1
  • Genomic Mutations
    1 involving Smad7
  • Incidental Mutations
Mice homozygous for a hypomorphic allele display partial penetrance of prenatal lethality, reduced body size and weight, smaller litter size and B cell abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024306 VEGA Gene Model | MGI Sequence Detail 28407 C57BL/6J ±  kb
transcript OTTMUST00000059530 VEGA | MGI Sequence Detail 4278 Not Applicable  
polypeptide OTTMUSP00000028959 VEGA | MGI Sequence Detail 426 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    165 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 38
    cDNA 32
    Primer pair 4
    Other 2

    Microarray probesets 3
References
more
  • Summaries
    All 134
    Developmental Gene Expression 38
    Gene Ontology 14
    Phenotypes 33
  • Earliest
    J:43278 Nakao A, et al., Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling [see comments]. Nature. 1997 Oct 9;389(6651):631-5
  • Latest
    J:226028 Lewandowski JP, et al., Spatiotemporal regulation of GLI target genes in the mammalian limb bud. Dev Biol. 2015 Oct 1;406(1):92-103

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory