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Smad7
Gene Detail
Symbol

Name
ID
Smad7
SMAD family member 7
MGI:1100518
Synonyms
Madh7
Feature Type
protein coding gene
Genetic Map
Chromosome 18
51.06 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr18:75367529-75395935 bp, + strand
From VEGA annotation of GRCm38

  28407 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4314  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 2 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SMAD7
Protein SuperFamily: Smad protein
Gene Tree: Smad7

Human
homologs
SMAD7, SMAD family member 7
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 4092
neXtProt AC: NX_O15105

Human Synonyms: CRCS3, MADH7, MADH8

Human Chr (Location): 18q21.1; chr18:48919853-48950711 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human SMAD7

Mutations,
alleles, and
phenotypes
All mutations/alleles(86) : Gene trapped(78) Targeted(8)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a hypomorphic allele display partial penetrance of prenatal lethality, reduced body size and weight, smaller litter size and B cell abnormalities.
 
Phenotype Images(4)
Interactions
Smad7 interacts with 281 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (63 annotations)
Process adherens junction assembly, artery morphogenesis, ...
Component catenin complex, cell-cell adherens junction, ...
Function activin binding, beta-catenin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (36 records)
Data Summary: Results (111)    Tissues (46)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 40
RT-PCR 70
cDNA source data(30)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase smad7 ; ZFIN smad7    NEW 
Molecular
reagents
All nucleic(37) cDNA(32) Primer pair(4) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000024306 (Evidence)
Ensembl Gene Model ENSMUSG00000025880 (Evidence)
Entrez Gene 17131 (Evidence)
UniGene 34407
DFCI TC1581985
DoTS DT.101362861
NIA Mouse Gene Index U018903
Consensus CDS Project CCDS37860.1
International Mouse Phenotyping Consortium Status Smad7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024306 VEGA Gene Model | MGI Sequence Detail 28407 C57BL/6J ±  kb
transcript OTTMUST00000059530 VEGA | MGI Sequence Detail 4278 Not Applicable 
polypeptide OTTMUSP00000028959 VEGA | MGI Sequence Detail 426 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(5) UniProt(4)
Polymorphisms
SNPs within 2kb(166 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013790 Dwarfin
InterPro IPR003619 MAD homology 1, Dwarfin-type
InterPro IPR013019 MAD homology, MH1
InterPro IPR001132 SMAD domain, Dwarfin-type
InterPro IPR017855 SMAD domain-like
InterPro IPR008984 SMAD/FHA domain
Protein Ontology PR:000000374 smad7
References
(Earliest) J:43278 Nakao A, et al., Identification of Smad7, a TGFbeta-inducible antagonist of TGF-beta signalling [see comments]. Nature. 1997 Oct 9;389(6651):631-5
(Latest) J:221441 Li Q, Inhibitory SMADs: potential regulators of ovarian function. Biol Reprod. 2015 Feb;92(2):50
All references(134)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory