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Fmo3
Gene Detail
 Symbol
Name
ID
Fmo3
flavin containing monooxygenase 3
MGI:1100496
Feature Type protein coding gene
Genetic Map
Chromosome 1
70.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:162953802-162984528 bp, - strand
From VEGA annotation of GRCm38

  30727 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128199  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: dimethylaniline monooxygenase (N-oxide-forming)
Gene Tree: Fmo3

Human
homologs
Human Homolog FMO3, flavin containing monooxygenase 3
NCBI Gene ID 2328
neXtProt AC  NX_P31513
Human Synonyms  dJ127D3.1, FMOII, TMAU
Human Chr (Location)  1q24.3; chr1:171090877-171117821 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human FMO3
Alleles
and
phenotypes
All alleles(1) : Targeted(1)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process drug metabolic process, oxidation-reduction process
Component endoplasmic reticulum, integral component of membrane, ...
Function amino acid binding, flavin adenine dinucleotide binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (123)    Tissues (123)    Images (8)
Theiler Stages: 19, 22, 23, 28
Assay TypeResults
RNA in situ 123
cDNA source data(20)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(23) cDNA(20) Primer pair(1) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000024141 (Evidence)
Ensembl Gene ModelENSMUSG00000026691 (Evidence)
Entrez Gene14262 (Evidence)
UniGene2900
DFCITC1585511, TC1596699
DoTSDT.490637, DT.94149774
NIA Mouse Gene IndexU021975
EC1.14.13.148, 1.14.13.8
Consensus CDS ProjectCCDS15426.1
International Mouse Knockout Project StatusFmo3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024141 VEGA Gene Model | MGI Sequence Detail 30727 C57BL/6J ±  kb
transcript OTTMUST00000059064 VEGA | MGI Sequence Detail 2044 Not Applicable 
polypeptide OTTMUSP00000028696 VEGA | MGI Sequence Detail 534 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(3)
Polymorphisms SNPs within 2kb(290 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012143 Dimethylaniline monooxygenase, N-oxide-forming
InterPro IPR000960 Flavin monooxygenase FMO
InterPro IPR002255 Flavin monooxygenase (FMO) 3
InterPro IPR020946 Flavin monooxygenase-like
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000007576 dimethylaniline monooxygenase [N-oxide-forming] 3
References (Earliest) J:16633 Lawton MP, et al., A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities. Arch Biochem Biophys. 1994 Jan;308(1):254-7
(Latest) J:195072 Bennett BJ, et al., Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab. 2013 Jan 8;17(1):49-60
All references(33)
Other
accession IDs
MGI:2138561

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory