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Fmo3
Gene Detail
Symbol

Name
ID
Fmo3
flavin containing monooxygenase 3
MGI:1100496
Feature Type
protein coding gene
Genetic Map
Chromosome 1
70.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:162953800-162984528 bp, - strand
From VEGA annotation of GRCm38

  30729 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:128199  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog

HCOP human homology predictions: FMO3
Protein SuperFamily: dimethylaniline monooxygenase (N-oxide-forming)
Gene Tree: Fmo3

Human
homologs
FMO3, flavin containing monooxygenase 3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2328
neXtProt AC: NX_P31513

Human Synonyms: dJ127D3.1, FMOII, TMAU

Human Chr (Location): 1q24.3; chr1:171090877-171117821 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human FMO3

Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Fmo3 interacts with 67 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (123)    Tissues (123)    Images (8)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 123
cDNA source data(20)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase fmo3    NEW 
Molecular
reagents
All nucleic(23) cDNA(20) Primer pair(1) Other(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000024141 (Evidence)
Ensembl Gene Model ENSMUSG00000026691 (Evidence)
Entrez Gene 14262 (Evidence)
UniGene 2900
DFCI TC1596699, TC1585511
DoTS DT.94149774, DT.490637
NIA Mouse Gene Index U021975
EC 1.14.13.8, 1.14.13.148
Consensus CDS Project CCDS15426.1
International Mouse Phenotyping Consortium Status Fmo3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024141 VEGA Gene Model | MGI Sequence Detail 30729 C57BL/6J ±  kb
transcript OTTMUST00000059064 VEGA | MGI Sequence Detail 2046 Not Applicable 
polypeptide OTTMUSP00000028696 VEGA | MGI Sequence Detail 534 Not Applicable 

For the selected sequences
All sequences(25) RefSeq(2) UniProt(3)
Polymorphisms
SNPs within 2kb(290 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012143 Dimethylaniline monooxygenase, N-oxide-forming
InterPro IPR000960 Flavin monooxygenase FMO
InterPro IPR002255 Flavin monooxygenase (FMO) 3
InterPro IPR020946 Flavin monooxygenase-like
InterPro IPR016040 NAD(P)-binding domain
Protein Ontology PR:000007576 dimethylaniline monooxygenase [N-oxide-forming] 3
References
(Earliest) J:16633 Lawton MP, et al., A nomenclature for the mammalian flavin-containing monooxygenase gene family based on amino acid sequence identities. Arch Biochem Biophys. 1994 Jan;308(1):254-7
(Latest) J:195072 Bennett BJ, et al., Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell Metab. 2013 Jan 8;17(1):49-60
All references(33)
Other
accession IDs
MGI:2138561

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory