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Nrp2
Gene Detail
Symbol

Name
ID
Nrp2
neuropilin 2
MGI:1100492
Synonyms
1110048P06Rik, NP2, NP-2, Npn2, Npn-2
Feature Type
protein coding gene
Genetic Map
Chromosome 1
31.35 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:62703285-62818695 bp, + strand
From VEGA annotation of GRCm38

  115411 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2875  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: neuropilin
Gene Tree: Nrp2

Human
homologs
Human Homolog NRP2, neuropilin 2
NCBI Gene ID 8828
neXtProt AC  NX_O60462
Human Synonyms  NP2, NPN2, PRO2714, VEGF165R2
Human Chr (Location)  2q33.3; chr2:205682460-205798133 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(37) : Gene trapped(30) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mice may exhibit pre- or postnatal lethality, reduced fertility, hydrocephalus, aberrant sensory innervation, reduced interneuron count, seizure susceptibility and abnormal lymphangiogenesis. Homozygotes for a gene trap allele show abnormal neuronal development and axonal trajectories.
 
Human Diseases Modeled Using Mouse Nrp2 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Nrp2 interacts with 434 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process angiogenesis, axon extension involved in axon guidance, ...
Component axon, integral component of membrane, ...
Function heparin binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (126 records)
Data Summary: Results (127)    Tissues (74)    Images (61)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 120
In situ reporter (knock in) 1
RT-PCR 4
cDNA source data(77)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(86) cDNA(78) Primer pair(3) Other(5)
Microarray probesets(6)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002566 VEGA Gene Model | MGI Sequence Detail 115411 C57BL/6J ±  kb
transcript OTTMUST00000004998 VEGA | MGI Sequence Detail 6357 Not Applicable 
polypeptide OTTMUSP00000002409 VEGA | MGI Sequence Detail 931 Not Applicable 

For the selected sequences
All sequences(99) RefSeq(12) UniProt(11)
Polymorphisms
SNPs within 2kb(651 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000421 Coagulation factor 5/8 C-terminal type domain
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR000859 CUB domain
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR000998 MAM domain
InterPro IPR014648 Neuropilin
InterPro IPR022579 Neuropilin-1, C-terminal
Protein Ontology PR:000011436 neuropilin-2
References
(Earliest) J:43454 Chen H, et al., Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. Neuron. 1997 Sep;19(3):547-59
(Latest) J:211667 Shahrabi-Farahani S, et al., Neuropilin 1 expression correlates with differentiation status of epidermal cells and cutaneous squamous cell carcinomas. Lab Invest. 2014 Jul;94(7):752-65
All references(195)
Disease annotation references (1)
Other
accession IDs
MGI:1916002

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory