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Nrp2 Gene Detail
Summary
  • Symbol
    Nrp2
  • Name
    neuropilin 2
  • Synonyms
    1110048P06Rik, NP2, NP-2, Npn2, Npn-2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1100492
    NCBI Gene: 18187
  • Gene Overview
    MyGene.info: NRP2
Location & Maps
more
  • Sequence Map
    Chr1:62703285-62818695 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      115411 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 31.35 cM, cytoband C2
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    NRP2, neuropilin 2
  • Vertebrate Orthologs
    11
  • Human Ortholog
    NRP2, neuropilin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    NP2, NPN2, PRO2714, VEGF165R2
  • Links
    NCBI Gene ID: 8828
    neXtProt AC: NX_O60462

  • Chr Location
    2q33.3; chr2:205682449-205798133 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 2875
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: NRP2
  • Protein SuperFamily
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Nrp2 mouse models

Human Disease Mouse Models
       Autism   OMIM: 209850 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 5 alleles in 8 genetic backgrounds
    15 phenotypes from multigenic genotypes
    77 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    36
  • Chemically induced (other)
    1
  • Gene trapped
    27
  • Radiation induced
    1
  • Targeted
    7
  • Genomic Mutations
    2 involving Nrp2
  • Incidental Mutations
Nullizygous mice may exhibit pre- or postnatal lethality, reduced fertility, hydrocephalus, aberrant sensory innervation, reduced interneuron count, seizure susceptibility and abnormal lymphangiogenesis. Homozygotes for a gene trap allele show abnormal neuronal development and axonal trajectories.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002566 VEGA Gene Model | MGI Sequence Detail 115411 C57BL/6J ±  kb
transcript OTTMUST00000004998 VEGA | MGI Sequence Detail 6357 Not Applicable  
polypeptide OTTMUSP00000002409 VEGA | MGI Sequence Detail 931 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    636 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 87
    cDNA 78
    Primer pair 3
    Other 6

    Microarray probesets 6
Other
Accession IDs
less
MGI:1916002
References
more
  • Summaries
    All 224
    Developmental Gene Expression 158
    Diseases 1
    Gene Ontology 12
    Phenotypes 77
  • Earliest
    J:43454 Chen H, et al., Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. Neuron. 1997 Sep;19(3):547-59
  • Latest
    J:235538 Tomann P, et al., Lhx2 is a direct NF-kappaB target gene that promotes primary hair follicle placode down-growth. Development. 2016 May 1;143(9):1512-22

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory