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Nrp2
Gene Detail
Symbol

Name
ID
Nrp2
neuropilin 2
MGI:1100492
Synonyms
1110048P06Rik, NP2, NP-2, Npn2, Npn-2
Feature Type
protein coding gene
Genetic Map
Chromosome 1
31.35 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:62703285-62818695 bp, + strand
From VEGA annotation of GRCm38

  115411 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2875  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: NRP2
Protein SuperFamily: neuropilin
Gene Tree: Nrp2

Human
homologs
NRP2, neuropilin 2
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8828
neXtProt AC: NX_O60462

Human Synonyms: NP2, NPN2, PRO2714, VEGF165R2

Human Chr (Location): 2q33.3; chr2:205682449-205798133 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(34) : Gene trapped(27) Targeted(7)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Nullizygous mice may exhibit pre- or postnatal lethality, reduced fertility, hydrocephalus, aberrant sensory innervation, reduced interneuron count, seizure susceptibility and abnormal lymphangiogenesis. Homozygotes for a gene trap allele show abnormal neuronal development and axonal trajectories.
 
Human Diseases Modeled in Mice Using Nrp2 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Nrp2 interacts with 433 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (38 annotations)
Process angiogenesis, axon extension involved in axon guidance, ...
Component axon, integral component of membrane, ...
Function heparin binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (140 records)
Data Summary: Results (130)    Tissues (77)    Images (64)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 120
In situ reporter (knock in) 1
RT-PCR 4
cDNA source data(77)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA NRP2 ; Xenbase nrp2 ; ZFIN nrp2a, nrp2b    NEW 
Molecular
reagents
All nucleic(86) cDNA(78) Primer pair(3) Other(5)
Microarray probesets(6)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002566 VEGA Gene Model | MGI Sequence Detail 115411 C57BL/6J ±  kb
transcript OTTMUST00000004998 VEGA | MGI Sequence Detail 6357 Not Applicable 
polypeptide OTTMUSP00000002409 VEGA | MGI Sequence Detail 931 Not Applicable 

For the selected sequences
All sequences(97) RefSeq(12) UniProt(6)
Polymorphisms
SNPs within 2kb(651 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000421 Coagulation factor 5/8 C-terminal domain
InterPro IPR013320 Concanavalin A-like lectin/glucanase domain
InterPro IPR000859 CUB domain
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR000998 MAM domain
InterPro IPR014648 Neuropilin
InterPro IPR022579 Neuropilin-1, C-terminal
InterPro IPR027143 Neuropilin-2
Protein Ontology PR:000011436 neuropilin-2
References
(Earliest) J:43454 Chen H, et al., Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. Neuron. 1997 Sep;19(3):547-59
(Latest) J:221787 Arbeille E, et al., Cerebrospinal fluid-derived Semaphorin3B orients neuroepithelial cell divisions in the apicobasal axis. Nat Commun. 2015;6:6366
All references(206)
Disease annotation references (1)
Other
accession IDs
MGI:1916002

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory