Nrp2
Gene Detail

Symbol Name ID

Nrp2 neuropilin 2 MGI:1100492

Synonyms

1110048P06Rik, NP2, NP-2, Npn2, Npn-2

Feature Type

protein coding gene

Genetic Map

Chromosome 1

31.35 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr1:62703285-62818695 bp, + strand From VEGA annotation of GRCm38   115411 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2875  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: neuropilin
Gene Tree: Nrp2

Human homologs

Human Homolog		NRP2, neuropilin 2
NCBI Gene ID		8828
neXtProt AC		NX_O60462
Human Synonyms		NP2, NPN2, PRO2714, VEGF165R2
Human Chr (Location)		2q33.3; chr2:206547224-206662857 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(37) : Targeted(7) Gene trapped(30)
 

Nullizygous mice may exhibit pre- or postnatal lethality, reduced fertility, hydrocephalus, aberrant sensory innervation, reduced interneuron count, seizure susceptibility and abnormal lymphangiogenesis. Homozygotes for a gene trap allele show abnormal neuronal development and axonal trajectories.

 
Human Diseases Modeled Using Mouse Nrp2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	angiogenesis, axon guidance, ...
Component	axon, integral to membrane, ...
Function	heparin binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (113 records)
Data Summary: Results (126)    Tissues (73)    Images (60)
Theiler Stages: 17, 19, 20, 21, 22, 23, 24, 26, 28

Assay Type	Results
Immunohistochemistry	1
RNA in situ	120
In situ reporter (knock in)	1
RT-PCR	4

cDNA source data(77)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(86) cDNA(78) Primer pair(3) Other(5)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000002566 (Evidence)
Ensembl Gene Model	ENSMUSG00000025969 (Evidence)
Entrez Gene	18187 (Evidence)
UniGene	266341
DFCI	TC1579111, TC1583685, TC1594714, TC1594851, TC1595028, TC1595875, TC1596612, TC1603083, TC1603233, TC1689698
DoTS	DT.101397720, DT.101737250, DT.110909541, DT.110909574, DT.110909584, DT.40133893, DT.528843, DT.91324629, DT.91336940, DT.91426565
NIA Mouse Gene Index	U000361
Consensus CDS Project	CCDS14995.1, CCDS35589.1, CCDS35590.1, CCDS35591.1, CCDS35592.1, CCDS35593.1
International Mouse Knockout Project Status	Nrp2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002566	VEGA Gene Model | MGI Sequence Detail	115411	C57BL/6J
transcript	OTTMUST00000004998	VEGA | MGI Sequence Detail	6357	Not Applicable
polypeptide	OTTMUSP00000002409	VEGA | MGI Sequence Detail	931	Not Applicable

All sequences(97) RefSeq(12) UniProt(9)

Polymorphisms

SNPs(493 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000421	Coagulation factor 5/8 C-terminal type domain
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR000859	CUB
InterPro	IPR008979	Galactose-binding domain-like
InterPro	IPR000998	MAM domain
InterPro	IPR014648	Neuropilin
InterPro	IPR022579	Neuropilin-1, C-terminal
Protein Ontology	PR:000011436	neuropilin-2

References

(Earliest) J:43454 Chen H, et al., Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. Neuron. 1997 Sep;19(3):547-59
(Latest) J:190719 Joza S, et al., Loss of semaphorin-neuropilin-1 signaling causes dysmorphic vascularization reminiscent of alveolar capillary dysplasia. Am J Pathol. 2012 Dec;181(6):2003-17
All references(176)

Other accession IDs

MGI:1916002