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Nrp2
Gene Detail
 Symbol
Name
ID
Nrp2
neuropilin 2
MGI:1100492
Synonyms 1110048P06Rik, NP2, NP-2, Npn2, Npn-2
Feature Type protein coding gene
Genetic Map
Chromosome 1
31.35 cM, cytoband C2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr1:62703285-62818695 bp, + strand
From VEGA annotation of GRCm38

  115411 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2875  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: neuropilin
Gene Tree: Nrp2

Human
homologs
Human Homolog NRP2, neuropilin 2
NCBI Gene ID 8828
neXtProt AC  NX_O60462
Human Synonyms  NP2, NPN2, PRO2714, VEGF165R2
Human Chr (Location)  2q33.3; chr2:205682460-205798133 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(37) : Gene trapped(30) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Nullizygous mice may exhibit pre- or postnatal lethality, reduced fertility, hydrocephalus, aberrant sensory innervation, reduced interneuron count, seizure susceptibility and abnormal lymphangiogenesis. Homozygotes for a gene trap allele show abnormal neuronal development and axonal trajectories.
 
Human Diseases Modeled Using Mouse Nrp2 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Nrp2 interacts with 434 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process angiogenesis, axon extension involved in axon guidance, ...
Component axon, integral component of membrane, ...
Function heparin binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (123 records)
Data Summary: Results (127)    Tissues (74)    Images (61)
Theiler Stages: 17, 19, 20, 21, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 120
In situ reporter (knock in) 1
RT-PCR 4
cDNA source data(77)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(86) cDNA(78) Primer pair(3) Other(5)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000002566 (Evidence)
Ensembl Gene ModelENSMUSG00000025969 (Evidence)
Entrez Gene18187 (Evidence)
UniGene266341
DFCITC1579111, TC1583685, TC1594714, TC1594851, TC1595028, TC1595875, TC1596612, TC1603083, TC1603233, TC1689698
DoTSDT.101397720, DT.101737250, DT.110909541, DT.110909574, DT.110909584, DT.40133893, DT.528843, DT.91324629, DT.91336940, DT.91426565
NIA Mouse Gene IndexU000361
Consensus CDS ProjectCCDS14995.1, CCDS35589.1, CCDS35590.1, CCDS35591.1, CCDS35592.1, CCDS35593.1
International Mouse Knockout Project StatusNrp2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002566 VEGA Gene Model | MGI Sequence Detail 115411 C57BL/6J ±  kb
transcript OTTMUST00000004998 VEGA | MGI Sequence Detail 6357 Not Applicable 
polypeptide OTTMUSP00000002409 VEGA | MGI Sequence Detail 931 Not Applicable 

For the selected sequences
All sequences(94) RefSeq(12) UniProt(6)
Polymorphisms SNPs within 2kb(651 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000421 Coagulation factor 5/8 C-terminal type domain
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR000859 CUB domain
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR000998 MAM domain
InterPro IPR014648 Neuropilin
InterPro IPR022579 Neuropilin-1, C-terminal
Protein Ontology PR:000011436 neuropilin-2
References (Earliest) J:43454 Chen H, et al., Neuropilin-2, a novel member of the neuropilin family, is a high affinity receptor for the semaphorins Sema E and Sema IV but not Sema III. Neuron. 1997 Sep;19(3):547-59
(Latest) J:211667 Shahrabi-Farahani S, et al., Neuropilin 1 expression correlates with differentiation status of epidermal cells and cutaneous squamous cell carcinomas. Lab Invest. 2014 Jul;94(7):752-65
All references(191)
Disease annotation references (1)
Other
accession IDs
MGI:1916002

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory