Phenotypes Associated with This Genotype

Genotype
MGI:4843917

• Allelic Composition: Nrp2^tm1.2Mom/Nrp2^tm1.2Mom
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * FVB/NJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:166116 )

• all mutants treated with KA to induce seizures die within a week

postnatal lethality, incomplete penetrance ( J:166116 )

• some mice die in spontaneous status epilepticus between P7 and P21

behavior/neurological

seizures ( J:166116 )

increased susceptibility to pharmacologically induced seizures ( J:166116 )

• all mutants treated with kainic acid (KA) to induce seizures die within a week

environmentally induced seizures ( J:166116 )

• 12 of 51 mice exhibit random handling-induced seizures

myoclonus ( J:166116 )

• 12 of 51 mice exhibit random handling-induced seizures

muscle

myoclonus ( J:166116 )

• 12 of 51 mice exhibit random handling-induced seizures

nervous system

seizures ( J:166116 )

increased susceptibility to pharmacologically induced seizures ( J:166116 )

• all mutants treated with kainic acid (KA) to induce seizures die within a week

environmentally induced seizures ( J:166116 )

• 12 of 51 mice exhibit random handling-induced seizures

myoclonus ( J:166116 )

• 12 of 51 mice exhibit random handling-induced seizures

abnormal hippocampus neuron morphology ( J:166116 )

• mutants exhibit selective loss of GABAergic cells in the hippocampus

• Parv+ and NPY+ neurons are reduced in the hippocampus

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autism spectrum disorder		DOID:0060041		J:166116