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Golgb1 Gene Detail
Summary
  • Symbol
    Golgb1
  • Name
    golgi autoantigen, golgin subfamily b, macrogolgin 1
  • Synonyms
    6330407A06Rik, C130074L01Rik, F730017E11Rik, Giantin, Gm6840
  • Feature Type
    protein coding gene
  • IDs
    MGI:1099447
    NCBI Gene: 224139
  • Gene Overview
    MyGene.info: GOLGB1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:36875140-36933085 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      57946 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 26.19 cM, cytoband B4
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    GOLGB1, golgin B1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GOLGB1, golgin B1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GCP, GCP372, GOLIM1
  • Links
    NCBI Gene ID: 2804
    neXtProt AC: NX_Q14789
    UniProt: Q14789

  • Chr Location
    3q13.33; chr3:121663199-121749908 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Golgb1 mouse models

Human Disease Mouse Models
      
IDs
View 5 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    7 phenotypes from multigenic genotypes
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous knockout affects glycosylation of glycoproteins in the extra-cellular matrix of the palatal shelves, resulting in their failure to elevate and fuse, leading to cleft palate.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000026955 VEGA Gene Model | MGI Sequence Detail 57946 C57BL/6J ±  kb
    transcript OTTMUST00000060899 VEGA | MGI Sequence Detail 11012 Not Applicable  
    polypeptide OTTMUSP00000029768 VEGA | MGI Sequence Detail 3197 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      383 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      13 Sequences
    • InterPro Domains
      IPR026202 Golgin subfamily B member 1
    Molecular
    Reagents
    less
    • All nucleic 134
      Genomic 1
      cDNA 133

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1925340, MGI:2146577, MGI:2443094, MGI:3779635
    References
    more
    • Summaries
      All 43
      Developmental Gene Expression 9
      Diseases 1
      Gene Ontology 5
      Phenotypes 8
    • Earliest
      J:42083 Diella F, et al., Characterization of the INT6 mammary tumor gene product. DNA Cell Biol. 1997 Jul;16(7):839-47
    • Latest
      J:242905 McGee LJ, et al., Golga5 is dispensable for mouse embryonic development and postnatal survival. Genesis. 2017 Jul;55(7)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory