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Tmem38b Gene Detail
Summary
  • Symbol
    Tmem38b
  • Name
    transmembrane protein 38B
  • Synonyms
    1600017F22Rik, D4Ertd89e, TRIC-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098718
    NCBI Gene: 52076
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:53826045-53862019 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 28.76 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    167 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098718
protein coding gene Chr4:53826045-53862019 (+)
129S1/SvImJ MGP_129S1SvImJ_G0028303
protein coding gene Chr4:52480294-52524031 (+)
A/J MGP_AJ_G0028264
protein coding gene Chr4:50457470-50496817 (+)
AKR/J MGP_AKRJ_G0028213
protein coding gene Chr4:51842577-51887595 (+)
BALB/cJ MGP_BALBcJ_G0028283
protein coding gene Chr4:50645325-50682660 (+)
C3H/HeJ MGP_C3HHeJ_G0028004
protein coding gene Chr4:52380408-52421205 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028724
protein coding gene Chr4:54402847-54444899 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026032
protein coding gene Chr4:47404436-47440639 (+)
CAST/EiJ MGP_CASTEiJ_G0027442
protein coding gene Chr4:52028370-52068704 (+)
CBA/J MGP_CBAJ_G0027969
protein coding gene Chr4:56254593-56302403 (+)
DBA/2J MGP_DBA2J_G0028119
protein coding gene Chr4:50432860-50472877 (+)
FVB/NJ MGP_FVBNJ_G0028086
protein coding gene Chr4:49653994-49696178 (+)
LP/J MGP_LPJ_G0028218
protein coding gene Chr4:52585507-52625103 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028110
protein coding gene Chr4:59456439-59501965 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028760
protein coding gene Chr4:52064921-52107510 (+)
PWK/PhJ MGP_PWKPhJ_G0027167
protein coding gene Chr4:50372486-50411967 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026995
protein coding gene Chr4:51348174-51389636 (+)
WSB/EiJ MGP_WSBEiJ_G0027520
protein coding gene Chr4:51971349-52012500 (+)



Homology
more
  • Human Ortholog
    TMEM38B, transmembrane protein 38B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TMEM38B, transmembrane protein 38B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA219P18.1, C9orf87, D4Ertd89e, OI14, TRICB, TRIC-B
  • Links
    NCBI Gene ID: 55151
    neXtProt AC: NX_Q9NVV0
    UniProt: Q9NVV0

  • Chr Location
    9q31.2; chr9:105694525-105776611 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human TMEM38B associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 1 allele in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null newborn mice die of respiratory failure showing atelectasis, pulmonary congestion, impaired maturation of alveolar type II cells, reduced lamellar body formation, abnormal synthesis and secretion of surfactant phospholipids, and impaired Ca2+ release in alveolar type II cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 52076 NCBI Gene Model | MGI Sequence Detail 35975 C57BL/6J ±  kb
transcript NM_028053 RefSeq | MGI Sequence Detail 2861 C57BL/6  
polypeptide Q9DAV9 UniProt | EBI | MGI Sequence Detail 292 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 34
    cDNA 33
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
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MGI:1919255, MGI:3034371, MGI:3034649
References
more
  • Summaries
    All 37
    Gene Ontology 5
    Phenotypes 12
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:258631 Zhao C, et al., Mice lacking the intracellular cation channel TRIC-B have compromised collagen production and impaired bone mineralization. Sci Signal. 2016 May 17;9(428):ra49

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
03/13/2019
MGI 6.13
The Jackson Laboratory