Tmem38b
Gene Detail

Symbol Name ID

Tmem38b transmembrane protein 38B MGI:1098718

Synonyms

1600017F22Rik, D4Ertd89e, TRIC-B

Feature Type

protein coding gene

Genetic Map

Chromosome 4

28.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr4:53826045-53862019 bp, + strand From VEGA annotation of GRCm38   35975 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:10010  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tmem38b

Human homologs

Human Homolog		TMEM38B, transmembrane protein 38B
NCBI Gene ID		55151
neXtProt AC		NX_Q9NVV0
Human Synonyms		bA219P18.1, C9orf87, D4Ertd89e, OI14, TRICB, TRIC-B
Human Chr (Location)		9q31.2; chr9:108456825-108537444 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human TMEM38B

Alleles and phenotypes

All alleles(50) : Targeted(4) Gene trapped(46)
 

Homozygous null newborn mice die of respiratory failure showing atelectasis, pulmonary congestion, impaired maturation of alveolar type II cells, reduced lamellar body formation, abnormal synthesis and secretion of surfactant phospholipids, and impaired Ca2+ release in alveolar type II cells.

 

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	ion transport, monovalent inorganic cation transport, ...
Component	endoplasmic reticulum, integral to membrane, ...
Function	cation channel activity, potassium channel activity

External Resources: FuncBase

Expression

cDNA source data(32)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(33) cDNA(32) Primer pair(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000007005 (Evidence)
Ensembl Gene Model	ENSMUSG00000028420 (Evidence)
Entrez Gene	52076 (Evidence)
UniGene	27184
DFCI	TC1581485, TC1635001, TC1718401
DoTS	DT.40165625, DT.525756, DT.94138454
NIA Mouse Gene Index	U042532
Consensus CDS Project	CCDS18193.1
International Mouse Knockout Project Status	Tmem38b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000007005	VEGA Gene Model | MGI Sequence Detail	35975	C57BL/6J
transcript	OTTMUST00000016196	VEGA | MGI Sequence Detail	2862	Not Applicable
polypeptide	OTTMUSP00000007422	VEGA | MGI Sequence Detail	292	Not Applicable

All sequences(39) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(141 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007866	TRIC channel
Protein Ontology	PR:000016428	trimeric intracellular cation channel type B

References

(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(38)

Other accession IDs

MGI:1919255, MGI:3034371, MGI:3034649