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Tmem38b
Gene Detail
 Symbol
Name
ID
Tmem38b
transmembrane protein 38B
MGI:1098718
Synonyms 1600017F22Rik, D4Ertd89e, TRIC-B
Feature Type protein coding gene
Genetic Map
Chromosome 4
28.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:53826045-53862019 bp, + strand
From VEGA annotation of GRCm38

  35975 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10010  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Tmem38b

Human
homologs
Human Homolog TMEM38B, transmembrane protein 38B
NCBI Gene ID 55151
neXtProt AC  NX_Q9NVV0
Human Synonyms  bA219P18.1, C9orf87, D4Ertd89e, OI14, TRICB, TRIC-B
Human Chr (Location)  9q31.2; chr9:105694525-105776611 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human TMEM38B
Alleles
and
phenotypes
All alleles(50) : Targeted(4) Gene trapped(46)
 
Homozygous null newborn mice die of respiratory failure showing atelectasis, pulmonary congestion, impaired maturation of alveolar type II cells, reduced lamellar body formation, abnormal synthesis and secretion of surfactant phospholipids, and impaired Ca2+ release in alveolar type II cells.
 
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process ion transport, monovalent inorganic cation transport, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function cation channel activity, potassium channel activity
External Resources: FuncBase
Expression
cDNA source data(32)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(33) cDNA(32) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000007005 (Evidence)
Ensembl Gene ModelENSMUSG00000028420 (Evidence)
Entrez Gene52076 (Evidence)
UniGene27184
DFCITC1581485, TC1635001, TC1718401
DoTSDT.40165625, DT.525756, DT.94138454
NIA Mouse Gene IndexU042532
Consensus CDS ProjectCCDS18193.1
International Mouse Knockout Project StatusTmem38b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007005 VEGA Gene Model | MGI Sequence Detail 35975 C57BL/6J ±  kb
transcript OTTMUST00000016196 VEGA | MGI Sequence Detail 2862 Not Applicable 
polypeptide OTTMUSP00000007422 VEGA | MGI Sequence Detail 292 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(167 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007866 TRIC channel
Protein Ontology PR:000016428 trimeric intracellular cation channel type B
References (Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:199616 Tao S, et al., Facilitated hyperpolarization signaling in vascular smooth muscle-overexpressing TRIC-A channels. J Biol Chem. 2013 May 31;288(22):15581-9
All references(38)
Other
accession IDs
MGI:1919255, MGI:3034371, MGI:3034649

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory