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Tmem38b Gene Detail
Summary
  • Symbol
    Tmem38b
  • Name
    transmembrane protein 38B
  • Synonyms
    1600017F22Rik, D4Ertd89e, TRIC-B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098718
    NCBI Gene: 52076
Location & Maps
more
  • Sequence Map
    Chr4:53826045-53862019 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      35975 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 28.76 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TMEM38B, transmembrane protein 38B
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TMEM38B, transmembrane protein 38B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    bA219P18.1, C9orf87, D4Ertd89e, OI14, TRICB, TRIC-B
  • Links
    NCBI Gene ID: 55151
    neXtProt AC: NX_Q9NVV0

  • Chr Location
    9q31.2; chr9:105694525-105776611 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human TMEM38B associations

Human Disease Mouse Models
       Osteogenesis Imperfecta, Type Xiv; OI14   OMIM: 615066
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 1 allele in 2 genetic backgrounds
    6 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    50
  • Gene trapped
    46
  • Targeted
    4
  • Incidental Mutations
Homozygous null newborn mice die of respiratory failure showing atelectasis, pulmonary congestion, impaired maturation of alveolar type II cells, reduced lamellar body formation, abnormal synthesis and secretion of surfactant phospholipids, and impaired Ca2+ release in alveolar type II cells.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007005 VEGA Gene Model | MGI Sequence Detail 35975 C57BL/6J ±  kb
transcript OTTMUST00000016196 VEGA | MGI Sequence Detail 2862 Not Applicable  
polypeptide OTTMUSP00000007422 VEGA | MGI Sequence Detail 292 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    167 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000016428 trimeric intracellular cation channel type B
  • InterPro Domains
    IPR007866 TRIC channel
Molecular
Reagents
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  • All nucleic 33
    cDNA 32
    Primer pair 1

    Microarray probesets 7
Other
Accession IDs
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MGI:1919255, MGI:3034371, MGI:3034649
References
more
  • Summaries
    All 38
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
  • Latest
    J:227247 Brommage R, et al., High-throughput screening of mouse gene knockouts identifies established and novel skeletal phenotypes. Bone Res. 2014;2:14034

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/27/2016
MGI 6.05
The Jackson Laboratory