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Tmem38b
Gene Detail
Symbol

Name
ID
Tmem38b
transmembrane protein 38B
MGI:1098718
Synonyms
1600017F22Rik, D4Ertd89e, TRIC-B
Feature Type
protein coding gene
Genetic Map
Chromosome 4
28.76 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr4:53826045-53862019 bp, + strand
From VEGA annotation of GRCm38

  35975 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:10010  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: TMEM38B
Gene Tree: Tmem38b

Human
homologs
TMEM38B, transmembrane protein 38B
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 55151
neXtProt AC: NX_Q9NVV0

Human Synonyms: bA219P18.1, C9orf87, D4Ertd89e, OI14, TRICB, TRIC-B

Human Chr (Location): 9q31.2; chr9:105694525-105776611 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human TMEM38B

Mutations,
alleles, and
phenotypes
All mutations/alleles(50) : Gene trapped(46) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null newborn mice die of respiratory failure showing atelectasis, pulmonary congestion, impaired maturation of alveolar type II cells, reduced lamellar body formation, abnormal synthesis and secretion of surfactant phospholipids, and impaired Ca2+ release in alveolar type II cells.
 
Interactions
Tmem38b interacts with 221 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (12 annotations)
Process ion transport, monovalent inorganic cation transport, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function cation channel activity, potassium channel activity
External Resources: FuncBase
Expression
cDNA source data(32)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tmem38b    NEW 
Molecular
reagents
All nucleic(33) cDNA(32) Primer pair(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000007005 (Evidence)
Ensembl Gene Model ENSMUSG00000028420 (Evidence)
Entrez Gene 52076 (Evidence)
UniGene 27184
DFCI TC1581485, TC1635001, TC1718401
DoTS DT.40165625, DT.525756, DT.94138454
NIA Mouse Gene Index U042532
Consensus CDS Project CCDS18193.1
International Mouse Phenotyping Consortium Status Tmem38b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000007005 VEGA Gene Model | MGI Sequence Detail 35975 C57BL/6J ±  kb
transcript OTTMUST00000016196 VEGA | MGI Sequence Detail 2862 Not Applicable 
polypeptide OTTMUSP00000007422 VEGA | MGI Sequence Detail 292 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(167 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007866 TRIC channel
Protein Ontology PR:000016428 trimeric intracellular cation channel type B
References
(Earliest) J:60984 Ko MS, et al., Large-scale cDNA analysis reveals phased gene expression patterns during preimplantation mouse development. Development. 2000 Apr;127(8):1737-49
(Latest) J:199616 Tao S, et al., Facilitated hyperpolarization signaling in vascular smooth muscle-overexpressing TRIC-A channels. J Biol Chem. 2013 May 31;288(22):15581-9
All references(38)
Other
accession IDs
MGI:1919255, MGI:3034371, MGI:3034649

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory