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Tet1 Gene Detail
Summary
  • Symbol
    Tet1
  • Name
    tet methylcytosine dioxygenase 1
  • Synonyms
    2510010B09Rik, BB001228, Cxxc6, D10Ertd17e, mKIAA1676
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098693
    NCBI Gene: 52463
Location & Maps
more
  • Sequence Map
    Chr10:62804577-62899118 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      94542 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 32.48 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    TET1, tet methylcytosine dioxygenase 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TET1, tet methylcytosine dioxygenase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bA119F7.1, CXXC6, LCX, MLL-TET1, TET1-MLL
  • Links
    NCBI Gene ID: 80312
    neXtProt AC: NX_Q8NFU7

  • Chr Location
    10q21; chr10:68560360-68694487 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    22 phenotypes from 4 alleles in 5 genetic backgrounds
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    585
  • Chemically induced (other)
    1
  • Gene trapped
    577
  • Radiation induced
    1
  • Targeted
    6
  • Genomic Mutations
    2 involving Tet1
  • Incidental Mutations
Mice homozygous for a knock-out allele exhibit mild embryonic growth retardation, decreased body size, and small litters. Mice homozygous for a different knock-out allele exhibit impaired adult neurogenesis, impaired spatial learning and impaired short-term memory retention.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037102 VEGA Gene Model | MGI Sequence Detail 94542 C57BL/6J ±  kb
transcript OTTMUST00000095512 VEGA | MGI Sequence Detail 14369 Not Applicable  
polypeptide OTTMUSP00000053294 VEGA | MGI Sequence Detail 2039 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    444 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 17
    cDNA 14
    Primer pair 3

    Microarray probesets 7
Other
Accession IDs
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MGI:1917568, MGI:2143481, MGI:2143889
References
more
  • Summaries
    All 77
    Developmental Gene Expression 11
    Gene Ontology 11
    Phenotypes 27
  • Earliest
    J:93290 Araki K, et al., Exchangeable gene trap using the Cre/mutated lox system. Cell Mol Biol (Noisy-le-grand). 1999 Jul;45(5):737-50
  • Latest
    J:230884 Zhu X, et al., Role of Tet1/3 Genes and Chromatin Remodeling Genes in Cerebellar Circuit Formation. Neuron. 2016 Jan 6;89(1):100-12

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory