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Stag1 Gene Detail
Summary
  • Symbol
    Stag1
  • Name
    stromal antigen 1
  • Synonyms
    SA-1, Scc3
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098658
    NCBI Gene: 20842
  • Gene Overview
    MyGene.info: STAG1
Location & Maps
more
  • Sequence Map
    Chr9:100597798-100959375 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      361578 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 52.77 cM, cytoband F1
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    STAG1, stromal antigen 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    STAG1, stromal antigen 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SA1, SCC3A
  • Links
    NCBI Gene ID: 10274
    neXtProt AC: NX_Q8WVM7

  • Chr Location
    3q22.3; chr3:136336234-136752403 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 1 allele in 1 genetic background
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    72
  • Chemically induced (other)
    1
  • Gene trapped
    69
  • Targeted
    2
  • Genomic Mutations
    1 involving Stag1
  • Incidental Mutations
Mouse embryos homozygous for a null mutation show developmental delay and die before birth. Heterozygous animals have shorter lifespan and earlier onset of tumourigenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034031 VEGA Gene Model | MGI Sequence Detail 361578 C57BL/6J ±  kb
transcript OTTMUST00000085912 VEGA | MGI Sequence Detail 6186 Not Applicable  
polypeptide OTTMUSP00000046456 VEGA | MGI Sequence Detail 1258 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2752 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 181
    cDNA 180
    Primer pair 1

    Microarray probesets 9
Other
Accession IDs
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MGI:2143240
References
more
  • Summaries
    All 43
    Developmental Gene Expression 7
    Gene Ontology 5
    Phenotypes 14
  • Earliest
    J:42879 Carramolino L, et al., SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs. Gene. 1997 Aug 22;195(2):151-9
  • Latest
    J:231644 Cuadrado A, et al., The contribution of cohesin-SA1 to gene expression and chromatin architecture in two murine tissues. Nucleic Acids Res. 2015 Mar 31;43(6):3056-67

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory