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Stag2 Gene Detail
Summary
  • Symbol
    Stag2
  • Name
    stromal antigen 2
  • Synonyms
    9230105L23Rik, B230112I07Rik, nuclear protein SA2, SA-2, SAP2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098583
    NCBI Gene: 20843
  • Gene Overview
    MyGene.info: STAG2
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:42149319-42277186 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 23.19 cM, cytoband A2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    153 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098583
protein coding gene ChrX:42149317-42277186 (.)
129S1/SvImJ MGP_129S1SvImJ_G0035675
protein coding gene ChrX:37216897-37347720 (+)
A/J MGP_AJ_G0035658
protein coding gene ChrX:37186948-37314973 (+)
AKR/J MGP_AKRJ_G0035578
protein coding gene ChrX:38077280-38212771 (+)
BALB/cJ MGP_BALBcJ_G0035644
protein coding gene ChrX:36862334-36990139 (+)
C3H/HeJ MGP_C3HHeJ_G0035348
protein coding gene ChrX:37532616-37664991 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036173
protein coding gene ChrX:38026096-38156626 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033025
protein coding gene ChrX:35293830-35425628 (+)
CAST/EiJ MGP_CASTEiJ_G0034639
protein coding gene ChrX:25368757-25501537 (+)
CBA/J MGP_CBAJ_G0035322
protein coding gene ChrX:39038544-39176391 (+)
DBA/2J MGP_DBA2J_G0035476
protein coding gene ChrX:36981969-37110350 (+)
FVB/NJ MGP_FVBNJ_G0035425
protein coding gene ChrX:36716235-36850646 (+)
LP/J MGP_LPJ_G0035564
protein coding gene ChrX:37530992-37661703 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035463
protein coding gene ChrX:39782724-39927701 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036191
protein coding gene ChrX:37169070-37299782 (+)
PWK/PhJ MGP_PWKPhJ_G0034338
protein coding gene ChrX:24924658-25057971 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034183
protein coding gene ChrX:25934281-26074351 (+)
WSB/EiJ MGP_WSBEiJ_G0034783
protein coding gene ChrX:36818084-36950716 (+)



Homology
more
  • Human Ortholog
    STAG2, stromal antigen 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    STAG2, stromal antigen 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    bA517O1.1, SA2, SA-2, SCC3B
  • Links
    NCBI Gene ID: 10735
    neXtProt AC: NX_Q8N3U4
    UniProt: Q8N3U4

  • Chr Location
    Xq25; chrX:123960560-124102656 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotype references
Knockdown of expression of this gene results in lineage skewing of hematopoietic stem cells and myeloproliferative disorders in aged mice.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20843 NCBI Gene Model | MGI Sequence Detail 127868 C57BL/6J ±  kb
transcript NM_001077712 RefSeq | MGI Sequence Detail 5977 C57BL/6  
polypeptide O35638 UniProt | EBI | MGI Sequence Detail 1231 Not Applicable  
For the selected sequence
Protein
Information
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Molecular
Reagents
less
  • All nucleic 133
    Genomic 2
    cDNA 130
    Primer pair 1

    Microarray probesets 4
Other
Accession IDs
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MGI:1925327, MGI:1925692
References
more
  • Summaries
    All 44
    Developmental Gene Expression 9
    Gene Ontology 8
    Phenotypes 9
  • Earliest
    J:42879 Carramolino L, et al., SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs. Gene. 1997 Aug 22;195(2):151-9
  • Latest
    J:229031 Mullenders J, et al., Cohesin loss alters adult hematopoietic stem cell homeostasis, leading to myeloproliferative neoplasms. J Exp Med. 2015 Oct 19;212(11):1833-50

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory