Rnasel
Gene Detail

Symbol Name ID

Rnasel ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent) MGI:1098272

Synonyms

2-5A-dependent RNAase, E230029I04Rik

Feature Type

protein coding gene

Genetic Map

Chromosome 1

65.43 cM, cytoband G2
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr1:153749426-153764221 bp, + strand From NCBI annotation of GRCm38   14796 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:8040  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Rnasel

Human homologs

Human Homolog		RNASEL, ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
NCBI Gene ID		6041
neXtProt AC		NX_Q05823
Human Synonyms		PRCA1, RNS4
Human Chr (Location)		1q25; chr1:182542769-182558394 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human RNASEL

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Mice homozygous for disruptions in this gene have an enlarged spleen and increased succeptibility to viral infection.

 

Gene Ontology (GO) classifications

All GO classifications: (21 annotations)

Process	defense response to virus, mRNA processing, ...
Component	cytoplasm, mitochondrion, ...
Function	ATP binding, endonuclease activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (13)    Tissues (6)    Images (9)
Theiler Stages: 24, 26, 28

Assay Type	Results
RNA in situ	13

cDNA source data(41)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(43) Genomic(1) cDNA(42)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000066800 (Evidence)
Entrez Gene	24014 (Evidence)
UniGene	259254
DFCI	TC1583651, TC1592244, TC1685802
DoTS	DT.101718411, DT.101734347, DT.521910, DT.91339940, DT.97413521
NIA Mouse Gene Index	U000932
EC	3.1.26.-
Consensus CDS Project	CCDS15377.1
International Mouse Knockout Project Status	Rnasel

Sequences

Length	Strain/Species
genomic	24014	NCBI Gene Model | MGI Sequence Detail	14796	C57BL/6J
transcript	NM_011882	RefSeq | MGI Sequence Detail	4758	C57BL/6
polypeptide	Q05921	UniProt | EBI | MGI Sequence Detail	735	Not Applicable

All sequences(33) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(57 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR002110	Ankyrin repeat
InterPro	IPR020683	Ankyrin repeat-containing domain
InterPro	IPR010513	KEN domain, ribonuclease activator
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR006567	PUG domain
Protein Ontology	PR:000014058	2-5A-dependent ribonuclease

Graphical View of Protein Domain Structure

References

(Earliest) J:43378 Zhou A, et al., Expression cloning of 2-5A-dependent RNAase: a uniquely regulated mediator of interferon action. Cell. 1993 Mar 12;72(5):753-65
(Latest) J:183021 Anderson BR, et al., Nucleoside modifications in RNA limit activation of 2'-5'-oligoadenylate synthetase and increase resistance to cleavage by RNase L. Nucleic Acids Res. 2011 Nov;39(21):9329-38
All references(45)

Other accession IDs

MGI:2445191