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Rnasel Gene Detail
Summary
  • Symbol
    Rnasel
  • Name
    ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
  • Synonyms
    2-5A-dependent RNAase, E230029I04Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098272
    NCBI Gene: 24014
  • Gene Overview
    MyGene.info: RNASEL
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr1:153749426-153764221 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      14796 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 65.43 cM, cytoband G2
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    RNASEL, ribonuclease L
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RNASEL, ribonuclease L
    Orthology source: HomoloGene, HGNC
  • Synonyms
    PRCA1, RNS4
  • Links
    NCBI Gene ID: 6041
    neXtProt AC: NX_Q05823
    UniProt: Q05823

  • Chr Location
    1q25.3; chr1:182573634-182589285 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human RNASEL associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene have an enlarged spleen and increased succeptibility to viral infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000043573 VEGA Gene Model | MGI Sequence Detail 14796 C57BL/6J ±  kb
    transcript OTTMUST00000114392 VEGA | MGI Sequence Detail 2938 Not Applicable  
    polypeptide OTTMUSP00000063843 VEGA | MGI Sequence Detail 735 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      167 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 41
      Genomic 1
      cDNA 40

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2445191
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 20
    • Earliest
      J:43378 Zhou A, et al., Expression cloning of 2-5A-dependent RNAase: a uniquely regulated mediator of interferon action. Cell. 1993 Mar 12;72(5):753-65
    • Latest
      J:239306 Goldstein SA, et al., Lineage A Betacoronavirus NS2 Proteins and the Homologous Torovirus Berne pp1a Carboxy-Terminal Domain Are Phosphodiesterases That Antagonize Activation of RNase L. J Virol. 2017 Mar 01;91(5)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory