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Rnasel
Gene Detail
 Symbol
Name
ID
Rnasel
ribonuclease L (2', 5'-oligoisoadenylate synthetase-dependent)
MGI:1098272
Synonyms 2-5A-dependent RNAase, E230029I04Rik
Feature Type protein coding gene
Genetic Map
Chromosome 1
65.43 cM, cytoband G2
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:153749504-153764221 bp, + strand
From VEGA annotation of GRCm38

  14718 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:8040  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Rnasel

Human
homologs
Human Homolog RNASEL, ribonuclease L (2',5'-oligoisoadenylate synthetase-dependent)
NCBI Gene ID 6041
neXtProt AC  NX_Q05823
Human Synonyms  PRCA1, RNS4
Human Chr (Location)  1q25; chr1:182573634-182589285 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human RNASEL
Alleles
and
phenotypes
All alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene have an enlarged spleen and increased succeptibility to viral infection.
 
Gene Ontology
(GO)
classifications
All GO classifications: (23 annotations)
Process defense response to virus, mRNA processing, ...
Component cytoplasm, mitochondrion, ...
Function ATP binding, bidentate ribonuclease III activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (13)    Tissues (6)    Images (9)
Theiler Stages: 24, 26, 28
Assay TypeResults
RNA in situ 13
cDNA source data(39)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(41) Genomic(1) cDNA(40)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000043573 (Evidence)
Ensembl Gene ModelENSMUSG00000066800 (Evidence)
Entrez Gene24014 (Evidence)
UniGene259254
DFCITC1583651, TC1592244, TC1685802
DoTSDT.101718411, DT.101734347, DT.521910, DT.91339940, DT.97413521
NIA Mouse Gene IndexU000932
EC3.1.26.-
Consensus CDS ProjectCCDS15377.1
International Mouse Knockout Project StatusRnasel
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000043573 VEGA Gene Model | MGI Sequence Detail 14718 C57BL/6J ±  kb
transcript OTTMUST00000114392 VEGA | MGI Sequence Detail 4576 Not Applicable 
polypeptide OTTMUSP00000063843 VEGA | MGI Sequence Detail 735 Not Applicable 

For the selected sequences
All sequences(71) RefSeq(14) UniProt(8)
Polymorphisms SNPs within 2kb(167 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002110 Ankyrin repeat
InterPro IPR020683 Ankyrin repeat-containing domain
InterPro IPR010513 KEN domain
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR006567 PUG domain
Protein Ontology PR:000014058 2-5A-dependent ribonuclease
References (Earliest) J:43378 Zhou A, et al., Expression cloning of 2-5A-dependent RNAase: a uniquely regulated mediator of interferon action. Cell. 1993 Mar 12;72(5):753-65
(Latest) J:205811 Zhou Y, et al., Role of ribonuclease L in viral pathogen-associated molecular pattern/influenza virus and cigarette smoke-induced inflammation and remodeling. J Immunol. 2013 Sep 1;191(5):2637-46
All references(50)
Other
accession IDs
MGI:2445191

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory