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Rgs2
Gene Detail
Symbol

Name
ID
Rgs2
regulator of G-protein signaling 2
MGI:1098271
Synonyms
GOS8
Feature Type
protein coding gene
Genetic Map
Chromosome 1
62.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr1:143999338-144004161 bp, - strand
From VEGA annotation of GRCm38

  4824 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2192  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: RGS2
Protein SuperFamily: regulator of G protein signaling, RGS4 type
Gene Tree: Rgs2

Human
homologs
RGS2, regulator of G-protein signaling 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 5997
neXtProt AC: NX_P41220

Human Synonyms: G0S8

Human Chr (Location): 1q31; chr1:192809039-192812277 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(2) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Heterozygous and homozygous mice for one allele display equivalent levels of blood pressure elevation, renovascular defects, persistent constriction of the resistance vasculature, and prolonged response of the vasculature to vasoconstrictors in vivo. Mice homozygous for another allele appear normal.
 
Interactions
Rgs2 interacts with 277 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process brown fat cell differentiation, cell cycle, ...
Component cytoplasm, cytoplasmic side of plasma membrane, ...
Function beta-tubulin binding, GTPase activator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (180)    Tissues (83)    Images (44)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 42
In situ reporter (knock in) 100
RT-PCR 38
cDNA source data(12)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase rgs2 ; ZFIN rgs2    NEW 
Molecular
reagents
All nucleic(13) cDNA(12) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000020882 (Evidence)
Ensembl Gene Model ENSMUSG00000026360 (Evidence)
Entrez Gene 19735 (Evidence)
DFCI TC1574514, TC1676935
DoTS DT.94157375, DT.494421
NIA Mouse Gene Index U021856
Consensus CDS Project CCDS15347.1
International Mouse Phenotyping Consortium Status Rgs2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020882 VEGA Gene Model | MGI Sequence Detail 4824 C57BL/6J ±  kb
transcript OTTMUST00000049364 VEGA | MGI Sequence Detail 3021 Not Applicable 
polypeptide OTTMUSP00000022856 VEGA | MGI Sequence Detail 211 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(41 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024066 Regulator of G-protein signaling, domain 1
InterPro IPR016137 Regulator of G protein signalling superfamily
Protein Ontology PR:000013954 regulator of G-protein signaling 2
References
(Earliest) J:39294 Chen C, et al., Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast. J Biol Chem. 1997 Mar 28;272(13):8679-85
(Latest) J:218502 Jang HS, et al., Regulator of G protein signaling 2 (RGS2) deficiency accelerates the progression of kidney fibrosis. Biochim Biophys Acta. 2014 Sep;1842(9):1733-41
All references(72)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory