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Rgs2
Gene Detail
 Symbol
Name
ID
Rgs2
regulator of G-protein signaling 2
MGI:1098271
Synonyms GOS8
Feature Type protein coding gene
Genetic Map
Chromosome 1
62.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr1:143999338-144004161 bp, - strand
From VEGA annotation of GRCm38

  4824 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2192  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: regulator of G protein signaling, RGS4 type
Gene Tree: Rgs2

Human
homologs
Human Homolog RGS2, regulator of G-protein signaling 2
NCBI Gene ID 5997
neXtProt AC  NX_P41220
Human Synonyms  G0S8
Human Chr (Location)  1q31; chr1:192809039-192812277 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Chemically induced (ENU)(2) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Heterozygous and homozygous mice for one allele display equivalent levels of blood pressure elevation, renovascular defects, persistent constriction of the resistance vasculature, and prolonged response of the vasculature to vasoconstrictors in vivo. Mice homozygous for another allele appear normal.
 
Interactions
Rgs2 interacts with 277 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (34 annotations)
Process brown fat cell differentiation, cell cycle, ...
Component cytoplasm, cytoplasmic side of plasma membrane, ...
Function beta-tubulin binding, GTPase activator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (180)    Tissues (83)    Images (44)
Theiler Stages: 23, 28
Assay TypeResults
RNA in situ 42
In situ reporter (knock in) 100
RT-PCR 38
cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(12) Primer pair(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000020882 (Evidence)
Ensembl Gene ModelENSMUSG00000026360 (Evidence)
Entrez Gene19735 (Evidence)
DFCITC1574514, TC1676935
DoTSDT.494421, DT.94157375
NIA Mouse Gene IndexU021856
Consensus CDS ProjectCCDS15347.1
International Mouse Knockout Project StatusRgs2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020882 VEGA Gene Model | MGI Sequence Detail 4824 C57BL/6J ±  kb
transcript OTTMUST00000049364 VEGA | MGI Sequence Detail 3021 Not Applicable 
polypeptide OTTMUSP00000022856 VEGA | MGI Sequence Detail 211 Not Applicable 

For the selected sequences
All sequences(37) RefSeq(2) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(41 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR024066 Regulator of G-protein signaling, domain 1
InterPro IPR000342 Regulator of G protein signalling
InterPro IPR016137 Regulator of G protein signalling superfamily
Protein Ontology PR:000013954 regulator of G-protein signaling 2
References (Earliest) J:39294 Chen C, et al., Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast. J Biol Chem. 1997 Mar 28;272(13):8679-85
(Latest) J:184284 Osei-Owusu P, et al., Regulator of G protein signaling 2 deficiency causes endothelial dysfunction and impaired endothelium-derived hyperpolarizing factor-mediated relaxation by dysregulating Gi/o signaling. J Biol Chem. 2012 Apr 6;287(15):12541-9
All references(71)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory