Rgs2
Gene Detail

Symbol Name ID

Rgs2 regulator of G-protein signaling 2 MGI:1098271

Synonyms

GOS8

Feature Type

protein coding gene

Genetic Map

Chromosome 1

62.56 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr1:143999338-144004161 bp, - strand From VEGA annotation of GRCm38   4824 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Rgs2 ± 2 cM)

Protein SuperFamily: regulator of G protein signaling, RGS4 type
Gene Tree: Rgs2

Human ortholog

RGS2 regulator of G-protein signaling 2, 24kDa NCBI Gene ID 5997
Human Synonyms: G0S8
Human Chr1:192778169-192781407 bp, + strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(8) : Targeted(6) Chemically induced(2)
 

Heterozygous and homozygous mice for one allele display equivalent levels of blood pressure elevation, renovascular defects, persistent constriction of the resistance vasculature, and prolonged response of the vasculature to vasoconstrictors in vivo. Mice homozygous for another allele appear normal.

 

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	brown fat cell differentiation, cell cycle, ...
Component	cytoplasm, cytosol, ...
Function	beta-tubulin binding, GTPase activator activity, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (180)    Tissues (83)    Images (44)
Theiler Stages: 23, 28

Assay Type	Results
RNA in situ	42
In situ reporter (knock in)	100
RT-PCR	38

cDNA source data(12)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(12) Primer pair(1)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000020882 (Evidence)
Ensembl Gene Model	ENSMUSG00000026360 (Evidence)
Entrez Gene	19735 (Evidence)
DFCI	TC1574514, TC1676935
DoTS	DT.494421, DT.94157375
NIA Mouse Gene Index	U021856
Consensus CDS Project	CCDS15347.1
International Mouse Knockout Project Status	Rgs2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000020882	VEGA Gene Model | MGI Sequence Detail	4824	C57BL/6J
transcript	OTTMUST00000049364	VEGA | MGI Sequence Detail	3021	Not Applicable
polypeptide	OTTMUSP00000022856	VEGA | MGI Sequence Detail	211	Not Applicable

All sequences(36) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs(24 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR024066	Regulator of G-protein signaling, domain 1
InterPro	IPR000342	Regulator of G protein signalling
InterPro	IPR016137	Regulator of G protein signalling superfamily
Protein Ontology	PR:000013954	regulator of G-protein signaling 2

References

(Earliest) J:39294 Chen C, et al., Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast. J Biol Chem. 1997 Mar 28;272(13):8679-85
(Latest) J:184284 Osei-Owusu P, et al., Regulator of G protein signaling 2 deficiency causes endothelial dysfunction and impaired endothelium-derived hyperpolarizing factor-mediated relaxation by dysregulating Gi/o signaling. J Biol Chem. 2012 Apr 6;287(15):12541-9
All references(70)