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Rgs2 Gene Detail
Summary
  • Symbol
    Rgs2
  • Name
    regulator of G-protein signaling 2
  • Synonyms
    GOS8
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098271
    NCBI Gene: 19735
  • Gene Overview
    MyGene.info: RGS2
Location & Maps
more
  • Sequence Map
    Chr1:143999338-144004161 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4824 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 62.56 cM
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    RGS2, regulator of G-protein signaling 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    RGS2, regulator of G-protein signaling 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    G0S8
  • Links
    NCBI Gene ID: 5997
    neXtProt AC: NX_P41220

  • Chr Location
    1q31.2; chr1:192809039-192812277 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    17 phenotypes from 3 alleles in 5 genetic backgrounds
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (ENU)
    2
  • Chemically induced (other)
    2
  • Targeted
    6
  • Genomic Mutations
    2 involving Rgs2
  • Incidental Mutations
Heterozygous and homozygous mice for one allele display equivalent levels of blood pressure elevation, renovascular defects, persistent constriction of the resistance vasculature, and prolonged response of the vasculature to vasoconstrictors in vivo. Mice homozygous for another allele appear normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020882 VEGA Gene Model | MGI Sequence Detail 4824 C57BL/6J ±  kb
transcript OTTMUST00000049364 VEGA | MGI Sequence Detail 3021 Not Applicable  
polypeptide OTTMUSP00000022856 VEGA | MGI Sequence Detail 211 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    41 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 13
    cDNA 12
    Primer pair 1

    Microarray probesets 6
References
more
  • Summaries
    All 68
    Developmental Gene Expression 6
    Gene Ontology 10
    Phenotypes 31
  • Earliest
    J:39294 Chen C, et al., Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast. J Biol Chem. 1997 Mar 28;272(13):8679-85
  • Latest
    J:218502 Jang HS, et al., Regulator of G protein signaling 2 (RGS2) deficiency accelerates the progression of kidney fibrosis. Biochim Biophys Acta. 2014 Sep;1842(9):1733-41

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory