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Kif5c
Gene Detail
 Symbol
Name
ID
Kif5c
kinesin family member 5C
MGI:1098269
Synonyms Khc, mKIAA0531
Feature Type protein coding gene
Genetic Map
Chromosome 2
28.68 cM, cytoband C
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr2:49619298-49774778 bp, + strand
From VEGA annotation of GRCm38

  155481 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56234  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: kinesin heavy chain
Gene Tree: Kif5c

Human
homologs
Human Homolog KIF5C, kinesin family member 5C
NCBI Gene ID 3800
neXtProt AC  NX_O60282
Human Synonyms  CDCBM2, KINN, NKHC, NKHC2, NKHC-2
Human Chr (Location)  2q23.1; chr2:148875223-149026759 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human KIF5C
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homezygous for disruptions in this gene are viable, fertile, and of normal size. The brain is normal but slightly reduced in size with decreased numbers of motor neurons an somewhat more sensory nerves than normal.
 
Interactions
Kif5c interacts with 404 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process ATP catabolic process, cytoskeleton-dependent intracellular transport, ...
Component ciliary rootlet, cytoplasm, ...
Function apolipoprotein receptor binding, ATPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (198)    Tissues (81)    Images (27)
Theiler Stages: 20, 21, 22, 23, 24, 26, 27, 28
Assay TypeResults
RNA in situ 198
cDNA source data(258)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(260) cDNA(260)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000012481 (Evidence)
Ensembl Gene ModelENSMUSG00000026764 (Evidence)
Entrez Gene16574 (Evidence)
UniGene256342
DFCITC1604170, TC1619857, TC1650353, TC1735654
DoTSDT.101249366, DT.60108010, DT.94183687
NIA Mouse Gene IndexU001744
Consensus CDS ProjectCCDS16024.1
International Mouse Knockout Project StatusKif5c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012481 VEGA Gene Model | MGI Sequence Detail 155481 C57BL/6J ±  kb
transcript OTTMUST00000029661 VEGA | MGI Sequence Detail 6856 Not Applicable 
polypeptide OTTMUSP00000013340 VEGA | MGI Sequence Detail 956 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2)
Polymorphisms RFLP(2) : SNPs within 2kb(912 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
Protein Ontology PR:000009318 kinesin heavy chain isoform 5C
References (Earliest) J:15086 Kato K, A collection of cDNA clones with specific expression patterns in mouse brain. Eur J Neurosci. 1990;2(8):704-11
(Latest) J:193925 Zivraj KH, et al., The RNA-binding protein MARTA2 regulates dendritic targeting of MAP2 mRNAs in rat neurons. J Neurochem. 2013 Mar;124(5):670-84
All references(45)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory