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Kif5c Gene Detail
Summary
  • Symbol
    Kif5c
  • Name
    kinesin family member 5C
  • Synonyms
    Khc, mKIAA0531
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098269
    NCBI Gene: 16574
  • Gene Overview
    MyGene.info: KIF5C
Location & Maps
more
  • Sequence Map
    Chr2:49619298-49774778 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      155481 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 28.68 cM, cytoband C
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    KIF5C, kinesin family member 5C
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KIF5C, kinesin family member 5C
    Orthology source: HomoloGene
  • Synonyms
    CDCBM2, KINN, NKHC, NKHC2, NKHC-2
  • Links
    NCBI Gene ID: 3800
    neXtProt AC: NX_O60282

  • Chr Location
    2q23.1; chr2:148875223-149026759 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with human KIF5C associations

Human Disease Mouse Models
       Cortical Dysplasia, Complex, with Other Brain Malformations 2; CDCBM2   OMIM: 615282
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    5
  • Chemically induced (other)
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Kif5c
  • Incidental Mutations
Mice homezygous for disruptions in this gene are viable, fertile, and of normal size. The brain is normal but slightly reduced in size with decreased numbers of motor neurons an somewhat more sensory nerves than normal.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000012481 VEGA Gene Model | MGI Sequence Detail 155481 C57BL/6J ±  kb
transcript OTTMUST00000029661 VEGA | MGI Sequence Detail 6856 Not Applicable  
polypeptide OTTMUSP00000013340 VEGA | MGI Sequence Detail 956 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    911 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000009318 kinesin heavy chain isoform 5C
Molecular
Reagents
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  • All nucleic 260
    cDNA 260

    Microarray probesets 7
References
more
  • Summaries
    All 45
    Developmental Gene Expression 7
    Gene Ontology 8
    Phenotypes 7
  • Earliest
    J:15086 Kato K, A collection of cDNA clones with specific expression patterns in mouse brain. Eur J Neurosci. 1990;2(8):704-11
  • Latest
    J:229250 Cui J, et al., Analysis of Kif5b expression during mouse kidney development. PLoS One. 2015;10(4):e0126002

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory