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Kif5c Gene Detail
Summary
  • Symbol
    Kif5c
  • Name
    kinesin family member 5C
  • Synonyms
    Khc, mKIAA0531
  • Feature Type
    protein coding gene
  • IDs
    MGI:1098269
    NCBI Gene: 16574
  • Gene Overview
    MyGene.info: KIF5C
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:49619314-49774778 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 28.68 cM, cytoband C
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    911 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1098269
protein coding gene Chr2:49619298-49774778 (.)
129S1/SvImJ MGP_129S1SvImJ_G0025723
protein coding gene Chr2:48799623-48969787 (+)
A/J MGP_AJ_G0025699
protein coding gene Chr2:46946716-47108721 (+)
AKR/J MGP_AKRJ_G0025669
protein coding gene Chr2:48297564-48459063 (+)
BALB/cJ MGP_BALBcJ_G0025694
protein coding gene Chr2:47068360-47226990 (+)
C3H/HeJ MGP_C3HHeJ_G0025455
protein coding gene Chr2:48279349-48440601 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026140
protein coding gene Chr2:50280236-50444977 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023546
protein coding gene Chr2:44991058-45149235 (+)
CAST/EiJ MGP_CASTEiJ_G0024920
protein coding gene Chr2:48338204-48506274 (+)
CBA/J MGP_CBAJ_G0025435
protein coding gene Chr2:52154523-52324418 (+)
DBA/2J MGP_DBA2J_G0025566
protein coding gene Chr2:46574427-46730915 (+)
FVB/NJ MGP_FVBNJ_G0025528
protein coding gene Chr2:46305378-46462061 (+)
LP/J MGP_LPJ_G0025654
protein coding gene Chr2:48733780-48896767 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025559
protein coding gene Chr2:53230138-53390058 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026198
protein coding gene Chr2:48197087-48358181 (+)
PWK/PhJ MGP_PWKPhJ_G0024661
protein coding gene Chr2:46453932-46616559 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024467
protein coding gene Chr2:48362706-48527756 (+)
WSB/EiJ MGP_WSBEiJ_G0024987
protein coding gene Chr2:48457153-48619494 (+)



Homology
more
  • Human Ortholog
    KIF5C, kinesin family member 5C
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KIF5C, kinesin family member 5C
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDCBM2, KINN, NKHC, NKHC2, NKHC-2
  • Links
    NCBI Gene ID: 3800
    neXtProt AC: NX_O60282
    UniProt: O60282

  • Chr Location
    2q23.1-q23.2; chr2:148875223-149026759 (+)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with human KIF5C associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 3 alleles in 3 genetic backgrounds
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homezygous for disruptions in this gene are viable, fertile, and of normal size. The brain is normal but slightly reduced in size with decreased numbers of motor neurons an somewhat more sensory nerves than normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 16574 NCBI Gene Model | MGI Sequence Detail 155465 C57BL/6J ±  kb
    transcript NM_008449 RefSeq | MGI Sequence Detail 6895 C57BL/6  
    polypeptide P28738 UniProt | EBI | MGI Sequence Detail 956 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 261
      cDNA 261

      Microarray probesets 7
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 8
      Gene Ontology 11
      Phenotypes 7
    • Earliest
      J:15086 Kato K, A collection of cDNA clones with specific expression patterns in mouse brain. Eur J Neurosci. 1990;2(8):704-11
    • Latest
      J:229250 Cui J, et al., Analysis of Kif5b expression during mouse kidney development. PLoS One. 2015;10(4):e0126002

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory