Kif12 MGI Mouse Gene Detail - MGI:1098232

Symbol

Kif12
Name

kinesin family member 12
Synonyms

N-9 kinesin

Feature Type

protein coding gene
IDs

MGI:1098232
NCBI Gene: 16552
Alliance

gene page
Transcription Start Sites

4 TSS

Sequence Map

Chr4:63083867-63090368 bp, - strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 33.96 cM, cytoband C1
Mapping Data

5 experiments

SNPs within 2kb

320 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1098232	protein coding gene	Chr4:63076185-63090382 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0028362	protein coding gene	Chr4:62167412-62173924 (-)
A/J	MGP_AJ_G0028323	protein coding gene	Chr4:59921569-59928081 (-)
AKR/J	MGP_AKRJ_G0028272	protein coding gene	Chr4:61565771-61572283 (-)
BALB/cJ	MGP_BALBcJ_G0028343	protein coding gene	Chr4:60088239-60094751 (-)
C3H/HeJ	MGP_C3HHeJ_G0028061	protein coding gene	Chr4:62080426-62086938 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028783	protein coding gene	Chr4:64303270-64309782 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026089	protein coding gene	Chr4:57257963-57264533 (-)
CAST/EiJ	MGP_CASTEiJ_G0027497	protein coding gene	Chr4:60047698-60054234 (-)
CBA/J	MGP_CBAJ_G0028028	protein coding gene	Chr4:66529769-66536281 (-)
DBA/2J	MGP_DBA2J_G0028178	protein coding gene	Chr4:59778009-59784521 (-)
FVB/NJ	MGP_FVBNJ_G0028143	protein coding gene	Chr4:59029076-59035588 (-)
LP/J	MGP_LPJ_G0028275	protein coding gene	Chr4:62433377-62439889 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0028170	protein coding gene	Chr4:69635872-69642384 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028819	protein coding gene	Chr4:61671690-61678202 (-)
PWK/PhJ	MGP_PWKPhJ_G0027224	protein coding gene	Chr4:58267847-58274479 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0027053	protein coding gene	Chr4:59134309-59140842 (-)
WSB/EiJ	MGP_WSBEiJ_G0027577	protein coding gene	Chr4:61671884-61678396 (-)

Human Ortholog

KIF12, kinesin family member 12

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

KIF12, kinesin family member 12
Synonyms

PFIC8
Links

HGNC:21495

NCBI Gene ID: 113220

UniProt: Q96FN5
Chr Location

9q32; chr9:114086126-114099292 (-) GRCh38

MGI Vertebrate Homology

Kif12 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: KIF12
Gene Tree

Kif12

Diseases

1 with Kif12 mouse models; 1 with human KIF12 associations

Human Disease

Mouse Models

metabolic dysfunction-associated steatohepatitis

IDs

View 1 model

progressive familial intrahepatic cholestasis

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

13 phenotypes from 1 allele in 1 genetic background
7 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

8
Endonuclease-mediated

2
Targeted

6
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

34 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

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All GO Annotations

20
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

717
Tissues

7
cDNA Data

21
Literature Summary

2

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA KIF12

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All Sequences

50
RefSeq

10
UniProt

6
CCDS

CCDS18249.1, CCDS89761.1

Ensembl

ENSMUSG00000028357 (Evidence)
NCBI Gene

16552

			Length	Strain/Species	Flank
genomic	ENSMUSG00000028357	Ensembl Gene Model \| MGI Sequence Detail	6502	C57BL/6J	± kb
transcript	ENSMUST00000156618	Ensembl \| MGI Sequence Detail	2258	Not Applicable
polypeptide	ENSMUSP00000152690	Ensembl \| MGI Sequence Detail	643	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000009285 kinesin-like protein KIF12

(term hierarchy)
InterPro Domains

IPR027640 Kinesin-like protein

IPR001752 Kinesin motor domain

IPR019821 Kinesin motor domain, conserved site

IPR036961 Kinesin motor domain superfamily

IPR027417 P-loop containing nucleoside triphosphate hydrolase

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All nucleic 23

Genomic 1

cDNA 21

Primer pair 1

Microarray probesets 3

Summaries

All 38

Developmental Gene Expression 2

Diseases 1

Gene Ontology 7

Phenotypes 7
Earliest

J:18490 Winter H, et al., Sequence and expression of murine type I hair keratins mHa2 and mHa3. Exp Cell Res. 1994 Jun;212(2):190-200
Latest

J:371295 Etemad A, et al., Mutations in the kinesin KIF12 promote MASH in humans and mice by disrupting lipogenic enzyme turnover. EMBO J. 2025 Mar;44(6):1608-1640

TSS for Kif12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr42036	Chr4:63090355-63090376 (-)	2 bp
Tssr42035	Chr4:63090323-63090339 (-)	37 bp
Tssr42034	Chr4:63090287-63090316 (-)	66 bp
Tssr42033	Chr4:63090254-63090261 (-)	110 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 08/05/2025 MGI 6.24