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Cenpe
Gene Detail
Symbol

Name
ID
Cenpe
centromere protein E
MGI:1098230
Synonyms
312kDa, CENP-E, Kif10, N-7 kinesin
Feature Type
protein coding gene
Genetic Map
Chromosome 3
62.55 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr3:135212537-135273611 bp, + strand
From VEGA annotation of GRCm38

  61075 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20429  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: CENPE
Gene Tree: Cenpe

Human
homologs
CENPE, centromere protein E, 312kDa
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1062
neXtProt AC: NX_Q02224

Human Synonyms: CENP-E, KIF10, MCPH13, PPP1R61

Human Chr (Location): 4q24-q25; chr4:103105806-103198409 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CENPE

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele display early embryonic lethality. Mutant embryos grown in culture exhibit inner cell mass growth defects and mitotic chromosome misalignment.
 
Interactions
Cenpe interacts with 172 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
cDNA source data(133)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cenpe    NEW 
Molecular
reagents
All nucleic(133) cDNA(133)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000054878 (Evidence)
Ensembl Gene Model ENSMUSG00000045328 (Evidence)
Entrez Gene 229841 (Evidence)
UniGene 161470
DFCI TC1580106, TC1601502, TC1624936
DoTS DT.40171555, DT.87028550
NIA Mouse Gene Index U042485
Consensus CDS Project CCDS51072.1
International Mouse Phenotyping Consortium Status Cenpe
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000054878 VEGA Gene Model | MGI Sequence Detail 61075 C57BL/6J ±  kb
transcript OTTMUST00000135967 VEGA | MGI Sequence Detail 7910 Not Applicable 
polypeptide OTTMUSP00000071861 VEGA | MGI Sequence Detail 2471 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(2) : SNPs within 2kb(658 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR027640 Kinesin-like protein
InterPro IPR001752 Kinesin motor domain
InterPro IPR019821 Kinesin motor domain, conserved site
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000005326 centromere-associated protein E
References
(Earliest) J:18490 Winter H, et al., Sequence and expression of murine type I hair keratins mHa2 and mHa3. Exp Cell Res. 1994 Jun;212(2):190-200
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(53)
Other
accession IDs
MGD-MRK-1941, MGI:2677846, MGI:3034640, MGI:88377

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory