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Cenpe
Gene Detail
 Symbol
Name
ID
Cenpe
centromere protein E
MGI:1098230
Synonyms 312kDa, CENP-E, Kif10, N-7 kinesin
Feature Type protein coding gene
Genetic Map
Chromosome 3
62.55 cM, cytoband H2
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr3:135212563-135273540 bp, + strand
From NCBI annotation of GRCm38

  60978 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20429  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Cenpe

Human
homologs
Human Homolog CENPE, centromere protein E, 312kDa
NCBI Gene ID 1062
neXtProt AC  NX_Q02224
Human Synonyms  CENP-E, KIF10, PPP1R61
Human Chr (Location)  4q24-q25; chr4:103105806-103198409 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display early embryonic lethality. Mutant embryos grown in culture exhibit inner cell mass growth defects and mitotic chromosome misalignment.
 
Interactions
Cenpe interacts with 172 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (46 annotations)
Process ATP catabolic process, attachment of spindle microtubules to kinetochore, ...
Component cell, chromosome, ...
Function ATPase activity, ATP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(133)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(133) cDNA(133)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000045328 (Evidence)
Entrez Gene229841 (Evidence)
UniGene161470
DFCITC1580106, TC1601502, TC1624936
DoTSDT.40171555, DT.87028550
NIA Mouse Gene IndexU042485
Consensus CDS ProjectCCDS51072.1
International Mouse Knockout Project StatusCenpe
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 229841 NCBI Gene Model | MGI Sequence Detail 60978 C57BL/6J ±  kb
transcript NM_173762 RefSeq | MGI Sequence Detail 7813 C57BL/6 
polypeptide Q6RT24 UniProt | EBI | MGI Sequence Detail 2474 Not Applicable 

For the selected sequences
All sequences(34) RefSeq(2) UniProt(2)
Polymorphisms RFLP(2) : SNPs within 2kb(658 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001752 Kinesin, motor domain
InterPro IPR019821 Kinesin, motor region, conserved site
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000005326 centromere-associated protein E
Graphical View of Protein Domain Structure
References (Earliest) J:18490 Winter H, et al., Sequence and expression of murine type I hair keratins mHa2 and mHa3. Exp Cell Res. 1994 Jun;212(2):190-200
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(52)
Other
accession IDs
MGD-MRK-1941, MGI:2677846, MGI:3034640, MGI:88377

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory