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Ogg1
Gene Detail
Symbol

Name
ID
Ogg1
8-oxoguanine DNA-glycosylase 1
MGI:1097693
Synonyms
Mmh
Feature Type
protein coding gene
Genetic Map
Chromosome 6
52.75 cM, cytoband E-F1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:113326972-113335068 bp, + strand
From VEGA annotation of GRCm38

  8097 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1909  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Ogg1

Human
homologs
Human Homolog OGG1, 8-oxoguanine DNA glycosylase
NCBI Gene ID 4968
neXtProt AC  NX_O15527
Human Synonyms  HMMH, HOGG1, MUTM, OGH1
Human Chr (Location)  3p26.2; chr3:9749944-9787790 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human OGG1
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(3) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene leads to accumulation of 8-hydroxyguanine and altered DNA repair. Mice homozygous for a knock-out allele remain healthy until at least 18 months of age. Mice homozygous for another knock-out allele develop spontaneouslung adenoma/carcinoma at ~1.5 years of age.
 
Interactions
Ogg1 interacts with 40 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process aging, base-excision repair, ...
Component mitochondrion, nuclear matrix, ...
Function 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(19) Genomic(1) cDNA(17) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000022453 (Evidence)
Ensembl Gene ModelENSMUSG00000030271 (Evidence)
Entrez Gene18294 (Evidence)
DFCITC1579351, TC1602919, TC1701111
DoTSDT.101137196, DT.101259955, DT.110491354, DT.50315141, DT.99854475
NIA Mouse Gene IndexU007267
EC3.2.2.-, 4.2.99.18
Consensus CDS ProjectCCDS20414.1
International Mouse Knockout Project StatusOgg1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022453 VEGA Gene Model | MGI Sequence Detail 8097 C57BL/6J ±  kb
transcript OTTMUST00000053690 VEGA | MGI Sequence Detail 1549 Not Applicable 
polypeptide OTTMUSP00000025541 VEGA | MGI Sequence Detail 345 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(8) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(77 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004577 8-oxoguanine DNA-glycosylase
InterPro IPR012904 8-oxoguanine DNA glycosylase, N-terminal
InterPro IPR011257 DNA glycosylase
InterPro IPR023170 Helix-turn-helix, base-excision DNA repair, C-terminal
InterPro IPR003265 HhH-GPD domain
Protein Ontology PR:000011616 N-glycosylase/DNA lyase
References
(Earliest) J:40805 Aburatani H, et al., Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue. Cancer Res. 1997 Jun 1;57(11):2151-6
(Latest) J:211877 Jalland CM, et al., Accelerated clinical course of prion disease in mice compromised in repair of oxidative DNA damage. Free Radic Biol Med. 2014 Mar;68:1-7
All references(95)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory