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Ogg1
Gene Detail
Symbol

Name
ID
Ogg1
8-oxoguanine DNA-glycosylase 1
MGI:1097693
Synonyms
Mmh
Feature Type
protein coding gene
Genetic Map
Chromosome 6
52.75 cM, cytoband E-F1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:113326972-113335068 bp, + strand
From VEGA annotation of GRCm38

  8097 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1909  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: OGG1
Gene Tree: Ogg1

Human
homologs
OGG1, 8-oxoguanine DNA glycosylase
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 4968
neXtProt AC: NX_O15527

Human Synonyms: HMMH, HOGG1, MUTM, OGH1

Human Chr (Location): 3p26.2; chr3:9749944-9788246 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human OGG1

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(3) Spontaneous(1) Targeted(6)
Genomic Mutations involving Ogg1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous inactivation of this gene leads to accumulation of 8-hydroxyguanine and altered DNA repair. Mice homozygous for a knock-out allele remain healthy until at least 18 months of age. Mice homozygous for another knock-out allele develop spontaneouslung adenoma/carcinoma at ~1.5 years of age.
 
Interactions
Ogg1 interacts with 40 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (52 annotations)
Process aging, base-excision repair, ...
Component mitochondrion, nuclear matrix, ...
Function 8-oxo-7,8-dihydroguanine DNA N-glycosylase activity, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ogg1 ; ZFIN ogg1    NEW 
Molecular
reagents
All nucleic(19) Genomic(1) cDNA(17) Primer pair(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000022453 (Evidence)
Ensembl Gene Model ENSMUSG00000030271 (Evidence)
Entrez Gene 18294 (Evidence)
DFCI TC1701111, TC1579351, TC1602919
DoTS DT.50315141, DT.110491354, DT.99854475, DT.101259955, DT.101137196
NIA Mouse Gene Index U007267
EC 4.2.99.18, 3.2.2.-
Consensus CDS Project CCDS20414.1
International Mouse Phenotyping Consortium Status Ogg1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022453 VEGA Gene Model | MGI Sequence Detail 8097 C57BL/6J ±  kb
transcript OTTMUST00000053690 VEGA | MGI Sequence Detail 1549 Not Applicable 
polypeptide OTTMUSP00000025541 VEGA | MGI Sequence Detail 345 Not Applicable 

For the selected sequences
All sequences(61) RefSeq(8) UniProt(3)
Polymorphisms
PCR(1) : SNPs within 2kb(77 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004577 8-oxoguanine DNA-glycosylase
InterPro IPR012904 8-oxoguanine DNA glycosylase, N-terminal
InterPro IPR011257 DNA glycosylase
InterPro IPR023170 Helix-turn-helix, base-excision DNA repair, C-terminal
InterPro IPR003265 HhH-GPD domain
Protein Ontology PR:000011616 N-glycosylase/DNA lyase
References
(Earliest) J:40805 Aburatani H, et al., Cloning and characterization of mammalian 8-hydroxyguanine-specific DNA glycosylase/apurinic, apyrimidinic lyase, a functional mutM homologue. Cancer Res. 1997 Jun 1;57(11):2151-6
(Latest) J:218808 Wang H, et al., Distinct roles of Ape1 protein, an enzyme involved in DNA repair, in high or low linear energy transfer ionizing radiation-induced cell killing. J Biol Chem. 2014 Oct 31;289(44):30635-44
All references(98)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory