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C3ar1 Gene Detail
Summary
  • Symbol
    C3ar1
  • Name
    complement component 3a receptor 1
  • Synonyms
    anaphylatoxin C3a receptor, C3aR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097680
    NCBI Gene: 12267
  • Gene Overview
    MyGene.info: C3AR1
Location & Maps
more
  • Sequence Map
    Chr6:122847138-122856161 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      9024 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 57.93 cM, cytoband F1
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    C3AR1, complement component 3a receptor 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    C3AR1, complement component 3a receptor 1
    Orthology source: HomoloGene
  • Synonyms
    AZ3B, C3AR, HNFAG09
  • Links
    NCBI Gene ID: 719
    neXtProt AC: NX_Q16581

  • Chr Location
    12p13.31; chr12:8058323-8066359 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 3 alleles in 5 genetic backgrounds
    1 phenotype from multigenic genotypes
    61 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous targeted mutants display protective effects against the changes in lung physiology after allergen challenge, increased lethality to endotoxin shock, and elevated IL1B following LPS challenge, supporting the role of C3arin proinflammatory responses.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034575 VEGA Gene Model | MGI Sequence Detail 9024 C57BL/6J ±  kb
transcript OTTMUST00000087717 VEGA | MGI Sequence Detail 4305 Not Applicable  
polypeptide OTTMUSP00000047744 VEGA | MGI Sequence Detail 477 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    33 from dbSNP Build 142
  • PCR
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000001104 C3a anaphylatoxin chemotactic receptor
  • InterPro Domains
    IPR002234 Anaphylatoxin chemotactic receptor family
    IPR001644 C3a anaphylatoxin chemotactic receptor
    IPR000826 Formyl peptide receptor-related
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
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  • All nucleic 33
    Genomic 3
    cDNA 29
    Primer pair 1

    Microarray probesets 5
References
more
  • Summaries
    All 90
    Gene Ontology 5
    Phenotypes 61
  • Earliest
    J:40631 Tornetta MA, et al., The mouse anaphylatoxin C3a receptor: molecular cloning, genomic organization, and functional expression. J Immunol. 1997 Jun 1;158(11):5277-82
  • Latest
    J:229777 Surace L, et al., Complement is a central mediator of radiotherapy-induced tumor-specific immunity and clinical response. Immunity. 2015 Apr 21;42(4):767-77

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory