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Bnc1
Gene Detail
Symbol

Name
ID
Bnc1
basonuclin 1
MGI:1097164
Feature Type
protein coding gene
Genetic Map
Chromosome 7
45.71 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr7:81966672-81992299 bp, - strand
From Ensembl annotation of GRCm38

  25628 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31048  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: BNC1
Gene Tree: Bnc1

Human
homologs
BNC1, basonuclin 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 646
neXtProt AC: NX_Q01954

Human Synonyms: BNC, BSN1, HsT19447

Human Chr (Location): 15q25.2; chr15:83255884-83284716 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit thinning and delayed wound healing of the corneal epithelium.
 
Interactions
Bnc1 interacts with 301 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process chromosome organization, positive regulation of epithelial cell proliferation, ...
Component cytoplasm, nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (137)    Tissues (116)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 31
RNA in situ 106
cDNA source data(19)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase bnc1 ; ZFIN bnc1    NEW 
Molecular
reagents
All nucleic(20) cDNA(19) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000025105 (Evidence)
Entrez Gene 12173 (Evidence)
UniGene 243802
DFCI TC1584392
DoTS DT.483100
NIA Mouse Gene Index U028791
Consensus CDS Project CCDS52285.1
International Mouse Phenotyping Consortium Status Bnc1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025105 Ensembl Gene Model | MGI Sequence Detail 25628 C57BL/6J ±  kb
transcript ENSMUST00000026096 Ensembl | MGI Sequence Detail 4653 Not Applicable 
polypeptide ENSMUSP00000026096 Ensembl | MGI Sequence Detail 990 Not Applicable 

For the selected sequences
All sequences(26) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(284 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
Protein Ontology PR:000004777 zinc finger protein basonuclin-1
References
(Earliest) J:42468 Matsuzaki K, et al., Conservation of human and mouse basonuclins as a guide to important features of the protein. Gene. 1997 Aug 11;195(1):87-92
(Latest) J:198994 Wu Y, et al., HSF2BP represses BNC1 transcriptional activity by sequestering BNC1 to the cytoplasm. FEBS Lett. 2013 Jul 11;587(14):2099-104
All references(35)
Other
accession IDs
MGI:2141862, MGI:2142253

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory