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Ptpro
Gene Detail
Symbol

Name
ID
Ptpro
protein tyrosine phosphatase, receptor type, O
MGI:1097152
Synonyms
D28, GLEPP1, PTP-BK, Ptpn15, PTP-oc, PTP-phi, PTPROt, PTP-U2
Feature Type
protein coding gene
Genetic Map
Chromosome 6
66.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:137252299-137464629 bp, + strand
From Ensembl annotation of GRCm38

  212331 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21564  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: receptor-type tyrosine-protein phosphatase O
Gene Tree: Ptpro

Human
homologs
Human Homolog PTPRO, protein tyrosine phosphatase, receptor type, O
NCBI Gene ID 5800
neXtProt AC  NX_Q16827
Human Synonyms  GLEPP1, NPHS6, PTP-OC, PTPROT, PTPU2, PTP-U2, R-PTP-O
Human Chr (Location)  12p13.3-p13.2; chr12:15322257-15598331 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PTPRO
Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one allele display impaired glomerular filtration due to podocyte structural anomalies and a predisposition for hypertension. Mice homozygous for a second allele exhibit susceptibility to pharmacologically induced seizures.
 
Phenotype Images(2)
Interactions
Ptpro interacts with 318 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process axon guidance, cell morphogenesis, ...
Component apical plasma membrane, dendritic spine, ...
Function hydrolase activity, phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (229)    Tissues (134)    Images (58)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 100
In situ reporter (knock in) 55
Northern blot 31
RT-PCR 43
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(23) cDNA(18) Primer pair(5)
Microarray probesets(4)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030223 Ensembl Gene Model | MGI Sequence Detail 212331 C57BL/6J ±  kb
transcript ENSMUST00000077115 Ensembl | MGI Sequence Detail 6617 Not Applicable 
polypeptide ENSMUSP00000076364 Ensembl | MGI Sequence Detail 1226 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(8) UniProt(22)
Polymorphisms
SNPs within 2kb(3042 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology PR:000013476 receptor-type tyrosine-protein phosphatase O
References
(Earliest) J:20475 Tagawa M, et al., Expression of protein tyrosine phosphatase genes in the developing brain of mouse and rat. Biochem Mol Biol Int. 1994 Aug;33(6):1221-7
(Latest) J:196589 Gatto G, et al., Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and Ret signaling. J Neurosci. 2013 Mar 20;33(12):5399-410
All references(52)
Other
accession IDs
MGD-MRK-27074, MGI:104711

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory