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Ptpro Gene Detail
Summary
  • Symbol
    Ptpro
  • Name
    protein tyrosine phosphatase, receptor type, O
  • Synonyms
    D28, GLEPP1, PTP-BK, Ptpn15, PTP-oc, PTP-phi, PTPROt, PTP-U2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1097152
    NCBI Gene: 19277
  • Gene Overview
    MyGene.info: PTPRO
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:137252319-137463233 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      210915 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 66.75 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    PTPRO, protein tyrosine phosphatase, receptor type O
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PTPRO, protein tyrosine phosphatase, receptor type O
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GLEPP1, NPHS6, PTP-OC, PTPROT, PTPU2, PTP-U2, R-PTP-O
  • Links
    NCBI Gene ID: 5800
    neXtProt AC: NX_Q16827
    UniProt: Q16827

  • Chr Location
    12p13.3-p13.2; chr12:15322257-15598331 (+)  GRCh38.p7

Human Diseases
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  • Diseases
    1 with human PTPRO associations

Human Disease Mouse Models
      
IDs
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Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 3 alleles in 3 genetic backgrounds
    2 images
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for one allele display impaired glomerular filtration due to podocyte structural anomalies and a predisposition for hypertension. Mice homozygous for a second allele exhibit susceptibility to pharmacologically induced seizures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000057549 VEGA Gene Model | MGI Sequence Detail 210915 C57BL/6J ±  kb
    transcript OTTMUST00000141495 VEGA | MGI Sequence Detail 5049 Not Applicable  
    polypeptide OTTMUSP00000073942 VEGA | MGI Sequence Detail 1226 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      2970 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
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    • All nucleic 23
      cDNA 18
      Primer pair 5

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-27074, MGI:104711
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 17
      Gene Ontology 12
      Phenotypes 11
    • Earliest
      J:20475 Tagawa M, et al., Expression of protein tyrosine phosphatase genes in the developing brain of mouse and rat. Biochem Mol Biol Int. 1994 Aug;33(6):1221-7
    • Latest
      J:257654 Memic F, et al., Transcription and Signaling Regulators in Developing Neuronal Subtypes of Mouse and Human Enteric Nervous System. Gastroenterology. 2018 Feb;154(3):624-636

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory