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Ptpro
Gene Detail
Symbol

Name
ID
Ptpro
protein tyrosine phosphatase, receptor type, O
MGI:1097152
Synonyms
D28, GLEPP1, PTP-BK, Ptpn15, PTP-oc, PTP-phi, PTPROt, PTP-U2
Feature Type
protein coding gene
Genetic Map
Chromosome 6
66.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:137252299-137464629 bp, + strand
From Ensembl annotation of GRCm38

  212331 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21564  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: PTPRO
Protein SuperFamily: receptor-type tyrosine-protein phosphatase O
Gene Tree: Ptpro

Human
homologs
PTPRO, protein tyrosine phosphatase, receptor type, O
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 5800
neXtProt AC: NX_Q16827

Human Synonyms: GLEPP1, NPHS6, PTP-OC, PTPROT, PTPU2, PTP-U2, R-PTP-O

Human Chr (Location): 12p13.3-p13.2; chr12:15322257-15598331 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human PTPRO

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Gene trapped(1) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for one allele display impaired glomerular filtration due to podocyte structural anomalies and a predisposition for hypertension. Mice homozygous for a second allele exhibit susceptibility to pharmacologically induced seizures.
 
Phenotype Images(2)
Interactions
Ptpro interacts with 317 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process axon guidance, cell morphogenesis, ...
Component apical plasma membrane, dendritic spine, ...
Function hydrolase activity, phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (229)    Tissues (134)    Images (58)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 100
In situ reporter (knock in) 55
Northern blot 31
RT-PCR 43
cDNA source data(18)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ptpro ; ZFIN ptpro    NEW 
Molecular
reagents
All nucleic(23) cDNA(18) Primer pair(5)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000030223 (Evidence)
Entrez Gene 19277 (Evidence)
DFCI TC1578139, TC1592621, TC1595657, TC1638389, TC1705279
DoTS DT.101146535, DT.101391313, DT.101391314, DT.101391317, DT.101736462, DT.103565564, DT.40170277, DT.87030649, DT.94216332, DT.97413516
NIA Mouse Gene Index U007504, U045036
EC 3.1.3.48
Consensus CDS Project CCDS20664.1, CCDS51943.1, CCDS51944.1
International Mouse Phenotyping Consortium Status Ptpro
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030223 Ensembl Gene Model | MGI Sequence Detail 212331 C57BL/6J ±  kb
transcript ENSMUST00000077115 Ensembl | MGI Sequence Detail 6617 Not Applicable 
polypeptide ENSMUSP00000076364 Ensembl | MGI Sequence Detail 1226 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(8) UniProt(11)
Polymorphisms
SNPs within 2kb(3042 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR029021 Protein-tyrosine phosphatase-like
InterPro IPR000242 PTP type protein phosphatase
InterPro IPR000387 Tyrosine specific protein phosphatases domain
Protein Ontology PR:000013476 receptor-type tyrosine-protein phosphatase O
References
(Earliest) J:20475 Tagawa M, et al., Expression of protein tyrosine phosphatase genes in the developing brain of mouse and rat. Biochem Mol Biol Int. 1994 Aug;33(6):1221-7
(Latest) J:196589 Gatto G, et al., Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and Ret signaling. J Neurosci. 2013 Mar 20;33(12):5399-410
All references(51)
Other
accession IDs
MGD-MRK-27074, MGI:104711

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory