Ptpro
Gene Detail

Symbol Name ID

Ptpro protein tyrosine phosphatase, receptor type, O MGI:1097152

Synonyms

D28, GLEPP1, PTP-BK, Ptpn15, PTP-oc, PTP-phi, PTPROt, PTP-U2

Feature Type

protein coding gene

Genetic Map

Chromosome 6

66.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr6:137252299-137464629 bp, + strand From Ensembl annotation of GRCm38   212331 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21564  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: receptor-type tyrosine-protein phosphatase O
Gene Tree: Ptpro

Human homologs

Human Homolog		PTPRO, protein tyrosine phosphatase, receptor type, O
NCBI Gene ID		5800
neXtProt AC		NX_Q16827
Human Synonyms		GLEPP1, NPHS6, PTP-OC, PTPROT, PTPU2, PTP-U2, R-PTP-O
Human Chr (Location)		12p13.3-p13.2; chr12:15475191-15751265 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human PTPRO

Alleles and phenotypes

All alleles(4) : Targeted(3) Gene trapped(1)
 

Mice homozygous for one allele display impaired glomerular filtration due to podocyte structural anomalies and a predisposition for hypertension. Mice homozygous for a second allele exhibit susceptibility to pharmacologically induced seizures.

 
Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (30 annotations)

Process	axon guidance, cell morphogenesis, ...
Component	apical plasma membrane, dendritic spine, ...
Function	hydrolase activity, phosphatase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (14 records)
Data Summary: Results (198)    Tissues (105)    Images (54)
Theiler Stages: 21, 23, 25, 26, 28

Assay Type	Results
RNA in situ	69
In situ reporter (knock in)	55
Northern blot	31
RT-PCR	43

cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(23) cDNA(18) Primer pair(5)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000030223 (Evidence)
Entrez Gene	19277 (Evidence)
DFCI	TC1578139, TC1592621, TC1595657, TC1638389, TC1705279
DoTS	DT.101146535, DT.101391313, DT.101391314, DT.101391317, DT.101736462, DT.103565564, DT.40170277, DT.87030649, DT.94216332, DT.97413516
NIA Mouse Gene Index	U007504, U045036
EC	3.1.3.48
Consensus CDS Project	CCDS20664.1, CCDS51943.1, CCDS51944.1
International Mouse Knockout Project Status	Ptpro

Sequences

Length	Strain/Species
genomic	ENSMUSG00000030223	Ensembl Gene Model | MGI Sequence Detail	212331	C57BL/6J
transcript	ENSMUST00000077115	Ensembl | MGI Sequence Detail	6617	Not Applicable
polypeptide	ENSMUSP00000076364	Ensembl | MGI Sequence Detail	1226	Not Applicable

All sequences(60) RefSeq(8) UniProt(12)

Polymorphisms

SNPs(1347 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003961	Fibronectin, type III
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR000387	Protein-tyrosine/Dual-specificity phosphatase
InterPro	IPR016130	Protein-tyrosine phosphatase, active site
InterPro	IPR000242	Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology	PR:000013476	receptor-type tyrosine-protein phosphatase O

References

(Earliest) J:20475 Tagawa M, et al., Expression of protein tyrosine phosphatase genes in the developing brain of mouse and rat. Biochem Mol Biol Int. 1994 Aug;33(6):1221-7
(Latest) J:184159 Antypa M, et al., Differential gene expression in migratory streams of cortical interneurons. Eur J Neurosci. 2011 Nov;34(10):1584-94
All references(49)

Other accession IDs

MGD-MRK-27074, MGI:104711