About   Help   FAQ
Ptpro
Gene Detail
 Symbol
Name
ID
Ptpro
protein tyrosine phosphatase, receptor type, O
MGI:1097152
Synonyms D28, GLEPP1, PTP-BK, Ptpn15, PTP-oc, PTP-phi, PTPROt, PTP-U2
Feature Type protein coding gene
Genetic Map
Chromosome 6
66.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr6:137252299-137464629 bp, + strand
From Ensembl annotation of GRCm38

  212331 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21564  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: receptor-type tyrosine-protein phosphatase O
Gene Tree: Ptpro

Human
homologs
Human Homolog PTPRO, protein tyrosine phosphatase, receptor type, O
NCBI Gene ID 5800
neXtProt AC  NX_Q16827
Human Synonyms  GLEPP1, NPHS6, PTP-OC, PTPROT, PTPU2, PTP-U2, R-PTP-O
Human Chr (Location)  12p13.3-p13.2; chr12:15322257-15598331 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human PTPRO
Alleles
and
phenotypes
All alleles(5) : Targeted(4) Gene trapped(1)
 
Mice homozygous for one allele display impaired glomerular filtration due to podocyte structural anomalies and a predisposition for hypertension. Mice homozygous for a second allele exhibit susceptibility to pharmacologically induced seizures.
 
Phenotype Images(2)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process axon guidance, cell morphogenesis, ...
Component apical plasma membrane, dendritic spine, ...
Function hydrolase activity, phosphatase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (16 records)
Data Summary: Results (229)    Tissues (128)    Images (58)
Theiler Stages: 21, 23, 25, 26, 28
Assay TypeResults
RNA in situ 100
In situ reporter (knock in) 55
Northern blot 31
RT-PCR 43
cDNA source data(18)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(23) cDNA(18) Primer pair(5)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000030223 (Evidence)
Entrez Gene19277 (Evidence)
DFCITC1578139, TC1592621, TC1595657, TC1638389, TC1705279
DoTSDT.101146535, DT.101391313, DT.101391314, DT.101391317, DT.101736462, DT.103565564, DT.40170277, DT.87030649, DT.94216332, DT.97413516
NIA Mouse Gene IndexU007504, U045036
EC3.1.3.48
Consensus CDS ProjectCCDS20664.1, CCDS51943.1, CCDS51944.1
International Mouse Knockout Project StatusPtpro
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030223 Ensembl Gene Model | MGI Sequence Detail 212331 C57BL/6J ±  kb
transcript ENSMUST00000077115 Ensembl | MGI Sequence Detail 6617 Not Applicable 
polypeptide ENSMUSP00000076364 Ensembl | MGI Sequence Detail 1226 Not Applicable 

For the selected sequences
All sequences(60) RefSeq(8) UniProt(12)
Polymorphisms SNPs within 2kb(3042 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003961 Fibronectin, type III
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR000387 Protein-tyrosine/Dual specificity phosphatase
InterPro IPR016130 Protein-tyrosine phosphatase, active site
InterPro IPR000242 Protein-tyrosine phosphatase, receptor/non-receptor type
Protein Ontology PR:000013476 receptor-type tyrosine-protein phosphatase O
References (Earliest) J:20475 Tagawa M, et al., Expression of protein tyrosine phosphatase genes in the developing brain of mouse and rat. Biochem Mol Biol Int. 1994 Aug;33(6):1221-7
(Latest) J:196589 Gatto G, et al., Protein tyrosine phosphatase receptor type O inhibits trigeminal axon growth and branching by repressing TrkB and Ret signaling. J Neurosci. 2013 Mar 20;33(12):5399-410
All references(52)
Other
accession IDs
MGD-MRK-27074, MGI:104711

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
04/15/2014
MGI 5.17
The Jackson Laboratory