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Eef1a1 Gene Detail
Summary
  • Symbol
    Eef1a1
  • Name
    eukaryotic translation elongation factor 1 alpha 1
  • Synonyms
    MGC:18758, MGC:27859, MGC:7551, MGC:8115, MGC:8209
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096881
    NCBI Gene: 13627
Location & Maps
more
  • Sequence Map
    Chr9:78478449-78489151 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      10703 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    EEF1A1, eukaryotic translation elongation factor 1 alpha 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    EEF1A1, eukaryotic translation elongation factor 1 alpha 1
    Orthology source: HomoloGene
  • Synonyms
    CCS3, CCS-3, EE1A1, EEF-1, EEF1A, eEF1A-1, EF1A, EF-Tu, GRAF-1EF, HNGC:16303, LENG7, PTI1
  • Links
    NCBI Gene ID: 1915
    neXtProt AC: NX_P68104

  • Chr Location
    6q14.1; chr6:73515750-73521032 (-)  GRCh38.p2

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    5 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    24 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    82
  • Chemically induced (other)
    1
  • Gene trapped
    76
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Eef1a1
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019692 VEGA Gene Model | MGI Sequence Detail 10703 C57BL/6J ±  kb
transcript OTTMUST00000047139 VEGA | MGI Sequence Detail 1794 Not Applicable  
polypeptide OTTMUSP00000021291 VEGA | MGI Sequence Detail 462 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    37 from dbSNP Build 137
Protein
Information
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  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000006903 elongation factor 1-alpha 1
  • InterPro Domains
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
    IPR000795 Transcription factor, GTP-binding domain
    IPR004539 Translation elongation factor EF1A, eukaryotic/archaeal
    IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
    IPR004160 Translation elongation factor EFTu/EF1A, C-terminal
    IPR004161 Translation elongation factor EFTu/EF1A, domain 2
    IPR009000 Translation protein, beta-barrel domain
    IPR031157 Tr-type G domain, conserved site
Molecular
Reagents
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  • All nucleic 58
    cDNA 56
    Primer pair 1
    Other 1

    Microarray probesets 2
References
more
  • Summaries
    All 69
    Developmental Gene Expression 12
    Diseases 1
    Gene Ontology 11
    Phenotypes 24
  • Earliest
    J:20252 Nagata S, et al., Polypeptide chain elongation factor 1 alpha (EF-1 alpha) from yeast: nucleotide sequence of one of the two genes for EF-1 alpha from Saccharomyces cerevisiae. EMBO J. 1984 Aug;3(8):1825-30
  • Latest
    J:227252 Hayakawa Y, et al., Mist1 Expressing Gastric Stem Cells Maintain the Normal and Neoplastic Gastric Epithelium and Are Supported by a Perivascular Stem Cell Niche. Cancer Cell. 2015 Dec 14;28(6):800-14

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory