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Eef1a1
Gene Detail
Symbol

Name
ID
Eef1a1
eukaryotic translation elongation factor 1 alpha 1
MGI:1096881
Synonyms
MGC:18758, MGC:27859, MGC:7551, MGC:8115, MGC:8209
Feature Type
protein coding gene
Genetic Map
Chromosome 9
43.65 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:78478449-78489151 bp, - strand
From VEGA annotation of GRCm38

  10703 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:100799  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: EEF1A1
Protein SuperFamily: translation elongation factor Tu
Gene Tree: Eef1a1

Human
homologs
EEF1A1, eukaryotic translation elongation factor 1 alpha 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1915
neXtProt AC: NX_P68104

Human Synonyms: CCS3, CCS-3, EE1A1, EEF-1, EEF1A, eEF1A-1, EF1A, EF-Tu, GRAF-1EF, HNGC:16303, LENG7, PTI1

Human Chr (Location): 6q14.1; chr6:73515750-73521032 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(81) : Gene trapped(76) Radiation induced(1) Targeted(4)
Genomic Mutations involving Eef1a1 (1)
Mutations Annotated to Human Diseases (1)   
Interactions
Eef1a1 interacts with 106 markers (Mir10a, Mir10b, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process cellular response to epidermal growth factor stimulus, protein homooligomerization, ...
Component cortical actin cytoskeleton, cytoplasm, ...
Function GTPase activity, GTP binding, ...
External Resources: FuncBase
Expression
Literature Summary: (12 records)
Data Summary: Results (90)    Tissues (69)    Images (14)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 44
RT-PCR 46
cDNA source data(55)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase eef1a1 ; ZFIN eef1a1b    NEW 
Molecular
reagents
All nucleic(58) cDNA(56) Primer pair(1) Other(1)
Microarray probesets(2)
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019692 VEGA Gene Model | MGI Sequence Detail 10703 C57BL/6J ±  kb
transcript OTTMUST00000047139 VEGA | MGI Sequence Detail 1794 Not Applicable 
polypeptide OTTMUSP00000021291 VEGA | MGI Sequence Detail 462 Not Applicable 

For the selected sequences
All sequences(177) RefSeq(2) UniProt(8)
Polymorphisms
SNPs within 2kb(37 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000795 Elongation factor, GTP-binding domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR004539 Translation elongation factor EF1A, eukaryotic/archaeal
InterPro IPR009001 Translation elongation factor EF1A/initiation factor IF2gamma, C-terminal
InterPro IPR004160 Translation elongation factor EFTu/EF1A, C-terminal
InterPro IPR004161 Translation elongation factor EFTu/EF1A, domain 2
InterPro IPR009000 Translation elongation/initiation factor/Ribosomal, beta-barrel
Protein Ontology PR:000006903 elongation factor 1-alpha 1
References
(Earliest) J:20252 Nagata S, et al., Polypeptide chain elongation factor 1 alpha (EF-1 alpha) from yeast: nucleotide sequence of one of the two genes for EF-1 alpha from Saccharomyces cerevisiae. EMBO J. 1984 Aug;3(8):1825-30
(Latest) J:217168 Stellas D, et al., Therapeutic effects of an anti-Myc drug on mouse pancreatic cancer. J Natl Cancer Inst. 2014 Dec;106(12)
All references(66)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory