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Defb1
Gene Detail
 Symbol
Name
ID
Defb1
defensin beta 1
MGI:1096878
Synonyms mBD-1
Feature Type protein coding gene
Genetic Map
Chromosome 8
10.35 cM, cytoband A4
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr8:21776599-21795185 bp, + strand
From VEGA annotation of GRCm38

  18587 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3822  Vertebrate Homology Class
1 mouse; 1 rat

Gene Tree: Defb1

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
 
Mice homozygous for a null allele exhibit a reduction in bacterial clearance and increased bacterial urine content.
 
Interactions
Defb1 interacts with 153 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (7 annotations)
Process defense response, defense response to bacterium, ...
Component extracellular region
External Resources: FuncBase
Expression
Literature Summary: (2 records)
cDNA source data(19)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) Genomic(6) cDNA(19) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000019983 (Evidence)
Ensembl Gene ModelENSMUSG00000044748 (Evidence)
Entrez Gene13214 (Evidence)
UniGene431316
DFCITC1581749
DoTSDT.531735
NIA Mouse Gene IndexU118006
Consensus CDS ProjectCCDS40282.1
International Mouse Knockout Project StatusDefb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019983 VEGA Gene Model | MGI Sequence Detail 18587 C57BL/6J ±  kb
transcript OTTMUST00000047618 VEGA | MGI Sequence Detail 872 Not Applicable 
polypeptide OTTMUSP00000021573 VEGA | MGI Sequence Detail 69 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(2) UniProt(2)
Polymorphisms RFLP(1) : SNPs within 2kb(93 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR006080 Beta defensin/Neutrophil defensin
InterPro IPR001855 Beta defensin type
Protein Ontology PR:000006380 beta-defensin 1
References (Earliest) J:40251 Huttner KM, et al., The mouse genome encodes a single homolog of the antimicrobial peptide human beta-defensin 1. FEBS Lett. 1997 Aug 11;413(1):45-9
(Latest) J:209166 Becknell B, et al., Expression and antimicrobial function of beta-defensin 1 in the lower urinary tract. PLoS One. 2013;8(10):e77714
All references(42)
Other
accession IDs
MGI:2142783

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory