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Pias2 Gene Detail
Summary
  • Symbol
    Pias2
  • Name
    protein inhibitor of activated STAT 2
  • Synonyms
    6330408K17Rik, ARIP3, Dib, Miz1, PIASxalpha, PIASxb, PIASxbeta
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096566
    NCBI Gene: 17344
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr18:77065208-77155708 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 18, 52.07 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    181 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096566
protein coding gene Chr18:77065208-77155710 (.)
129S1/SvImJ MGP_129S1SvImJ_G0024572
protein coding gene Chr18:77799325-77892094 (+)
A/J MGP_AJ_G0024539
protein coding gene Chr18:74392826-74489495 (+)
AKR/J MGP_AKRJ_G0024510
protein coding gene Chr18:76600209-76690123 (+)
BALB/cJ MGP_BALBcJ_G0024538
protein coding gene Chr18:74621849-74710172 (+)
C3H/HeJ MGP_C3HHeJ_G0024307
protein coding gene Chr18:76705999-76798421 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024985
protein coding gene Chr18:79848523-79942970 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022415
protein coding gene Chr18:73424670-73509796 (+)
CAST/EiJ MGP_CASTEiJ_G0023779
protein coding gene Chr18:76970929-77071621 (+)
CBA/J MGP_CBAJ_G0024276
protein coding gene Chr18:82648559-82761223 (+)
DBA/2J MGP_DBA2J_G0024406
protein coding gene Chr18:73983499-74074586 (+)
FVB/NJ MGP_FVBNJ_G0024372
protein coding gene Chr18:73340749-73425629 (+)
LP/J MGP_LPJ_G0024490
protein coding gene Chr18:77678890-77779979 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024402
protein coding gene Chr18:83933951-84051654 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025033
protein coding gene Chr18:76756400-76857429 (+)
PWK/PhJ MGP_PWKPhJ_G0023524
protein coding gene Chr18:74397497-74488883 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023328
protein coding gene Chr18:76952528-77045996 (+)
WSB/EiJ MGP_WSBEiJ_G0023843
protein coding gene Chr18:76722150-76811003 (+)



Homology
more
  • Human Ortholog
    PIAS2, protein inhibitor of activated STAT 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PIAS2, protein inhibitor of activated STAT 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ARIP3, DIP, MIZ1, PIASX, SIZ2, ZMIZ4
  • Links
    NCBI Gene ID: 9063
    neXtProt AC: NX_O75928
    UniProt: O75928

  • Chr Location
    18q21.1; chr18:46803224-46920167 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    16 phenotypes from 2 alleles in 2 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
An uncharacterized gene trap insertion does not result in an obvious phenotype although abnormalities are reported in the testes.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025423 Ensembl Gene Model | MGI Sequence Detail 90501 C57BL/6J ±  kb
    transcript ENSMUST00000114777 Ensembl | MGI Sequence Detail 4968 Not Applicable  
    polypeptide ENSMUSP00000110425 Ensembl | MGI Sequence Detail 621 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 194
      cDNA 190
      Primer pair 3
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGI:1917978, MGI:2147235, MGI:2147299
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 8
      Gene Ontology 17
      Phenotypes 14
    • Earliest
      J:42027 Wu L, et al., Miz1, a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA. Mech Dev. 1997 Jul;65(1-2):3-17
    • Latest
      J:260447 Usui N, et al., Foxp1 regulation of neonatal vocalizations via cortical development. Genes Dev. 2017 Oct 15;31(20):2039-2055

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory