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Pias2
Gene Detail
 Symbol
Name
ID
Pias2
protein inhibitor of activated STAT 2
MGI:1096566
Synonyms 6330408K17Rik, ARIP3, Dib, Miz1, PIASxalpha, PIASxb, PIASxbeta
Feature Type protein coding gene
Genetic Map
Chromosome 18
52.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:77065208-77155708 bp, + strand
From NCBI annotation of GRCm38

  90501 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20979  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: E3 SUMO-protein ligase PIAS
Gene Tree: Pias2

Human
homologs
Human Homolog PIAS2, protein inhibitor of activated STAT, 2
NCBI Gene ID 9063
neXtProt AC  NX_O75928
Human Synonyms  ARIP3, DIP, MIZ, MIZ1, PIASX, PIASX-ALPHA, PIASX-BETA, SIZ2, ZMIZ4
Human Chr (Location)  18q21.1; chr18:46808937-46920167 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(239) : Gene trapped(238) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
An uncharacterized gene trap insertion does not result in an obvious phenotype during the observation period early in life, although abnormalities may still develop at older age.
 
Interactions
Pias2 interacts with 320 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (44 annotations)
Process androgen receptor signaling pathway, negative regulation of androgen receptor signaling pathway, ...
Component nuclear body, nucleus, ...
Function androgen receptor binding, coenzyme F420-0 gamma-glutamyl ligase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (52)    Tissues (50)    Images (6)
Theiler Stages: 2, 3, 4, 5, 15, 17, 19, 21, 22, 23, 28
Assay TypeResults
RNA in situ 39
Northern blot 5
RT-PCR 8
cDNA source data(188)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(191) cDNA(189) Primer pair(2)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000025423 (Evidence)
Entrez Gene17344 (Evidence)
UniGene6370
DFCITC1575464, TC1581866, TC1587190, TC1594992, TC1623267, TC1642669, TC1643789
DoTSDT.101126866, DT.101401361, DT.484792, DT.101401362, DT.101401363, DT.110783918, DT.97350876
NIA Mouse Gene IndexU018914
EC6.3.2.-
Consensus CDS ProjectCCDS37866.1, CCDS50323.1, CCDS50324.1
International Mouse Knockout Project StatusPias2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 17344 NCBI Gene Model | MGI Sequence Detail 90501 C57BL/6J ±  kb
transcript NM_001164168 RefSeq | MGI Sequence Detail 4984 C57BL/6 
polypeptide Q8C5D8 UniProt | EBI | MGI Sequence Detail 621 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(16) UniProt(5)
Polymorphisms SNPs within 2kb(185 from dbSNP Build 137)    SNPs within 2kb including multiple locations(187)
Protein-related
information
ResourceIDDescription
InterPro IPR027228 E3 SUMO-protein ligase PIAS2
InterPro IPR023321 PINIT domain
InterPro IPR003034 SAP domain
InterPro IPR004181 Zinc finger, MIZ-type
Protein Ontology PR:000003436 E3 SUMO-protein ligase PIAS2
Graphical View of Protein Domain Structure
References (Earliest) J:42027 Wu L, et al., Miz1, a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA. Mech Dev. 1997 Jul;65(1-2):3-17
(Latest) J:202177 Lu J, et al., Regulation of hedgehog signaling by Myc-interacting zinc finger protein 1, Miz1. PLoS One. 2013;8(5):e63353
All references(62)
Other
accession IDs
MGI:1917978, MGI:2147235, MGI:2147299

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory