About   Help   FAQ
Pias2
Gene Detail
Symbol

Name
ID
Pias2
protein inhibitor of activated STAT 2
MGI:1096566
Synonyms
6330408K17Rik, ARIP3, Dib, Miz1, PIASxalpha, PIASxb, PIASxbeta
Feature Type
protein coding gene
Genetic Map
Chromosome 18
52.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr18:77065208-77155708 bp, + strand
From Ensembl annotation of GRCm38

  90501 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20979  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PIAS2
Protein SuperFamily: E3 SUMO-protein ligase PIAS
Gene Tree: Pias2

Human
homologs
PIAS2, protein inhibitor of activated STAT, 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9063
neXtProt AC: NX_O75928

Human Synonyms: ARIP3, DIP, MIZ, MIZ1, PIASX, PIASX-ALPHA, PIASX-BETA, SIZ2, ZMIZ4

Human Chr (Location): 18q21.1; chr18:46808246-46920167 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(239) : Gene trapped(238) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
An uncharacterized gene trap insertion does not result in an obvious phenotype during the observation period early in life, although abnormalities may still develop at older age.
 
Interactions
Pias2 interacts with 320 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (52)    Tissues (50)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 39
Northern blot 5
RT-PCR 8
cDNA source data(188)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA PIAS2 ; Xenbase pias2    NEW 
Molecular
reagents
All nucleic(191) cDNA(189) Primer pair(2)
Microarray probesets(7)
Other database
links
Ensembl Gene Model ENSMUSG00000025423 (Evidence)
Entrez Gene 17344 (Evidence)
UniGene 6370
DFCI TC1575464, TC1581866, TC1587190, TC1594992, TC1623267, TC1642669, TC1643789
DoTS DT.101126866, DT.101401361, DT.101401362, DT.101401363, DT.110783918, DT.484792, DT.97350876
NIA Mouse Gene Index U018914
EC 6.3.2.-
Consensus CDS Project CCDS37866.1, CCDS50323.1, CCDS50324.1
International Mouse Phenotyping Consortium Status Pias2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025423 Ensembl Gene Model | MGI Sequence Detail 90501 C57BL/6J ±  kb
transcript ENSMUST00000114777 Ensembl | MGI Sequence Detail 4968 Not Applicable 
polypeptide ENSMUSP00000110425 Ensembl | MGI Sequence Detail 621 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(14) UniProt(5)
Polymorphisms
SNPs within 2kb(185 from dbSNP Build 137)    SNPs within 2kb including multiple locations(187)
Protein-related
information
ResourceIDDescription
InterPro IPR027228 E3 SUMO-protein ligase PIAS2
InterPro IPR023321 PINIT domain
InterPro IPR003034 SAP domain
InterPro IPR004181 Zinc finger, MIZ-type
Protein Ontology PR:000003436 E3 SUMO-protein ligase PIAS2
References
(Earliest) J:42027 Wu L, et al., Miz1, a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA. Mech Dev. 1997 Jul;65(1-2):3-17
(Latest) J:202177 Lu J, et al., Regulation of hedgehog signaling by Myc-interacting zinc finger protein 1, Miz1. PLoS One. 2013;8(5):e63353
All references(63)
Other
accession IDs
MGI:1917978, MGI:2147235, MGI:2147299

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory