Automated description from the Alliance of Genome Resources (Release 7.1.0)
Enables several functions, including RNA polymerase II-specific DNA-binding transcription factor binding activity; SUMO transferase activity; and ubiquitin protein ligase binding activity. Acts upstream of or within DNA-templated transcription; protein sumoylation; and regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including branchial arch; central nervous system; early conceptus; embryo mesenchyme; and genitourinary system. Orthologous to human PIAS2 (protein inhibitor of activated STAT 2).