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Snai2 Gene Detail
Summary
  • Symbol
    Snai2
  • Name
    snail family zinc finger 2
  • Synonyms
    Slug, Slugh, Snail2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096393
    NCBI Gene: 20583
  • Gene Overview
    MyGene.info: SNAI2
Location & Maps
more
  • Sequence Map
    Chr16:14705859-14709385 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3527 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 10.07 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SNAI2, snail family transcriptional repressor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SNAI2, snail family transcriptional repressor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SLUG, SLUGH1, SNAIL2, WS2D
  • Links
    NCBI Gene ID: 6591
    neXtProt AC: NX_O43623

  • Chr Location
    8q11; chr8:48917677-48921440 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 31127
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: SNAI2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Snai2 mouse models; 2 with human SNAI2 associations

Human Disease Mouse Models
       Waardenburg Syndrome, Type 2D; WS2D   OMIM: 608890 View 1 model
       Piebald Trait; PBT   OMIM: 172800
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    39 phenotypes from 5 alleles in 6 genetic backgrounds
    31 phenotypes from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations in this gene result in growth retardation and eyelid deformities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20583 NCBI Gene Model | MGI Sequence Detail 3527 C57BL/6J ±  kb
transcript NM_011415 RefSeq | MGI Sequence Detail 2084 Not Specified  
polypeptide P97469 UniProt | EBI | MGI Sequence Detail 269 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    38 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000015309 zinc finger protein SNAI2
  • InterPro Domains
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 42
    Genomic 3
    cDNA 33
    Primer pair 6

    Microarray probesets 4
References
more
  • Summaries
    All 115
    Developmental Gene Expression 56
    Diseases 1
    Gene Ontology 19
    Phenotypes 26
  • Earliest
    J:41071 Savagner P, et al., The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. J Cell Biol. 1997 Jun 16;137(6):1403-19
  • Latest
    J:234018 Singh S, et al., Zeb1 controls neuron differentiation and germinal zone exit by a mesenchymal-epithelial-like transition. Elife. 2016;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory