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Snai2 Gene Detail
Summary
  • Symbol
    Snai2
  • Name
    snail family zinc finger 2
  • Synonyms
    Slug, Slugh, Snail2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096393
    NCBI Gene: 20583
  • Gene Overview
    MyGene.info: SNAI2
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:14705859-14709385 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 10.07 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    38 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096393
protein coding gene Chr16:14705852-14709385 (.)
129S1/SvImJ MGP_129S1SvImJ_G0022548
protein coding gene Chr16:11800651-11804194 (+)
A/J MGP_AJ_G0022510
protein coding gene Chr16:11099197-11102722 (+)
AKR/J MGP_AKRJ_G0022486
protein coding gene Chr16:11599333-11602981 (+)
BALB/cJ MGP_BALBcJ_G0022514
protein coding gene Chr16:11280229-11283790 (+)
C3H/HeJ MGP_C3HHeJ_G0022281
protein coding gene Chr16:11674704-11678253 (+)
C57BL/6NJ MGP_C57BL6NJ_G0022963
protein coding gene Chr16:11966111-11969654 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020483
protein coding gene Chr16:11284588-11288112 (+)
CAST/EiJ MGP_CASTEiJ_G0021808
protein coding gene Chr16:11705103-11708702 (+)
CBA/J MGP_CBAJ_G0022250
protein coding gene Chr16:12472858-12476407 (+)
DBA/2J MGP_DBA2J_G0022381
protein coding gene Chr16:11096452-11100001 (+)
FVB/NJ MGP_FVBNJ_G0022357
protein coding gene Chr16:11118532-11122067 (+)
LP/J MGP_LPJ_G0022449
protein coding gene Chr16:11658320-11661863 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022379
protein coding gene Chr16:12109697-12113508 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0022976
protein coding gene Chr16:11552689-11556232 (+)
PWK/PhJ MGP_PWKPhJ_G0021550
protein coding gene Chr16:11347872-11351527 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021379
protein coding gene Chr16:11515416-11518965 (+)
WSB/EiJ MGP_WSBEiJ_G0021856
protein coding gene Chr16:11574037-11577598 (+)



Homology
more
  • Human Ortholog
    SNAI2, snail family transcriptional repressor 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SNAI2, snail family transcriptional repressor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SLUG, SLUGH, SLUGH1, SNAIL2, WS2D
  • Links
    NCBI Gene ID: 6591
    neXtProt AC: NX_O43623
    UniProt: O43623

  • Chr Location
    8q11.21; chr8:48917677-48921440 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 31127
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SNAI2
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with Snai2 mouse models; 2 with human SNAI2 associations

Human Disease Mouse Models
      
IDs
View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    42 phenotypes from 5 alleles in 6 genetic backgrounds
    31 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations in this gene result in growth retardation and eyelid deformities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20583 NCBI Gene Model | MGI Sequence Detail 3527 C57BL/6J ±  kb
    transcript NM_011415 RefSeq | MGI Sequence Detail 2031 C57BL/6  
    polypeptide P97469 UniProt | EBI | MGI Sequence Detail 269 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 44
      Genomic 3
      cDNA 34
      Primer pair 7

      Microarray probesets 4
    References
    more
    • Summaries
      All 155
      Developmental Gene Expression 74
      Diseases 1
      Gene Ontology 21
      Phenotypes 32
    • Earliest
      J:41071 Savagner P, et al., The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. J Cell Biol. 1997 Jun 16;137(6):1403-19
    • Latest
      J:265501 Kim H, et al., Ablation of Ezh2 in neural crest cells leads to aberrant enteric nervous system development in mice. PLoS One. 2018;13(8):e0203391

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory