Snai2
Gene Detail

Symbol Name ID

Snai2 snail homolog 2 (Drosophila) MGI:1096393

Synonyms

Slug, Slugh, Snail2

Feature Type

protein coding gene

Genetic Map

Chromosome 16

10.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr16:14705859-14709385 bp, + strand From NCBI annotation of GRCm38   3527 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:31127  Vertebrate Homology Class
1 human; 1 mouse; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Snai2

Human homologs

Human Homolog		SNAI2, snail homolog 2 (Drosophila)
NCBI Gene ID		6591
neXtProt AC		NX_O43623
Human Synonyms		SLUG, SLUGH1, SNAIL2, WS2D
Human Chr (Location)		8q11; chr8:49830236-49833999 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human SNAI2

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Mutations in this gene result in growth retardation and eyelid deformities.

 
Human Diseases Modeled Using Mouse Snai2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (71 annotations)

Process	canonical Wnt receptor signaling pathway, cartilage morphogenesis, ...
Component	cytoplasm, nuclear chromatin, ...
Function	chromatin binding, DNA binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (37 records)
Data Summary: Results (307)    Tissues (161)    Images (69)
Theiler Stages: 11, 13, 15, 16, 17, 19, 20, 21, 23, 26, 28

Assay Type	Results
Immunohistochemistry	4
RNA in situ	252
In situ reporter (knock in)	33
Northern blot	12
RT-PCR	6

cDNA source data(32)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(39) Genomic(3) cDNA(32) Primer pair(4)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000022676 (Evidence)
Entrez Gene	20583 (Evidence)
UniGene	4272
DFCI	TC1583379, TC1749395
DoTS	DT.87069417
NIA Mouse Gene Index	U016845
Consensus CDS Project	CCDS27974.1
International Mouse Knockout Project Status	Snai2

Sequences

Length	Strain/Species
genomic	20583	NCBI Gene Model | MGI Sequence Detail	3527	C57BL/6J
transcript	NM_011415	RefSeq | MGI Sequence Detail	2084	Not Specified
polypeptide	P97469	UniProt | EBI | MGI Sequence Detail	269	Not Applicable

All sequences(18) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(2) : SNPs(32 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007087	Zinc finger, C2H2
InterPro	IPR015880	Zinc finger, C2H2-like
InterPro	IPR013087	Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology	PR:000015309	zinc finger protein SNAI2

Graphical View of Protein Domain Structure

References

(Earliest) J:41071 Savagner P, et al., The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. J Cell Biol. 1997 Jun 16;137(6):1403-19
(Latest) J:192176 Casanova JC, et al., Epithelial-to-mesenchymal transition in epicardium is independent of snail1. Genesis. 2013 Jan;51(1):32-40
All references(92)