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Snai2
Gene Detail
Symbol

Name
ID
Snai2
snail family zinc finger 2
MGI:1096393
Synonyms
Slug, Slugh, Snail2
Feature Type
protein coding gene
Genetic Map
Chromosome 16
10.07 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:14705859-14709385 bp, + strand
From NCBI annotation of GRCm38

  3527 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:31127  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SNAI2
Gene Tree: Snai2

Human
homologs
SNAI2, snail family zinc finger 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6591
neXtProt AC: NX_O43623

Human Synonyms: SLUG, SLUGH1, SNAIL2, WS2D

Human Chr (Location): 8q11; chr8:48917677-48921440 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human SNAI2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this gene result in growth retardation and eyelid deformities.
 
Human Diseases Modeled in Mice Using Snai2 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Snai2 interacts with 216 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (74 annotations)
Process canonical Wnt signaling pathway, cartilage morphogenesis, ...
Component cytoplasm, nuclear chromatin, ...
Function chromatin binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (49 records)
Data Summary: Results (432)    Tissues (271)    Images (71)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 6
RNA in situ 343
In situ reporter (knock in) 61
Northern blot 12
RT-PCR 10
cDNA source data(33)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA SNAI2 ; Xenbase snai2 ; ZFIN snai2    NEW 
Molecular
reagents
All nucleic(41) Genomic(3) cDNA(33) Primer pair(5)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000022676 (Evidence)
Entrez Gene 20583 (Evidence)
UniGene 4272
DFCI TC1583379, TC1749395
DoTS DT.87069417
NIA Mouse Gene Index U016845
Consensus CDS Project CCDS27974.1
International Mouse Phenotyping Consortium Status Snai2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20583 NCBI Gene Model | MGI Sequence Detail 3527 C57BL/6J ±  kb
transcript NM_011415 RefSeq | MGI Sequence Detail 2084 Not Specified 
polypeptide P97469 UniProt | EBI | MGI Sequence Detail 269 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(2)
Polymorphisms
RFLP(2) : SNPs within 2kb(39 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR029795 SNAIL family
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000015309 zinc finger protein SNAI2
Graphical View of Protein Domain Structure
References
(Earliest) J:41071 Savagner P, et al., The zinc-finger protein slug causes desmosome dissociation, an initial and necessary step for growth factor-induced epithelial-mesenchymal transition. J Cell Biol. 1997 Jun 16;137(6):1403-19
(Latest) J:221041 Horvay K, et al., Snai1 regulates cell lineage allocation and stem cell maintenance in the mouse intestinal epithelium. EMBO J. 2015 May 12;34(10):1319-35
All references(109)
Disease annotation references (1)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory