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Hcn1
Gene Detail
 Symbol
Name
ID
Hcn1
hyperpolarization-activated, cyclic nucleotide-gated K+ 1
MGI:1096392
Synonyms Bcng1, C630013B14Rik, HAC2
Feature Type protein coding gene
Genetic Map
Chromosome 13
66.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:117602480-117976802 bp, + strand
From VEGA annotation of GRCm38

  374323 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32093  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel proteins
Gene Tree: Hcn1

Human
homologs
Human Homolog HCN1, hyperpolarization activated cyclic nucleotide-gated potassium channel 1
NCBI Gene ID 348980
neXtProt AC  NX_O60741
Human Synonyms  BCNG1, BCNG-1, EIEE24, HAC-2
Human Chr (Location)  5p12; chr5:45254950-45696118 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human HCN1
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this allele display learning deficiencies but are otherwise normal. Mice homozygous for another targeted knock-out exhibit deficit in hyperpolarization-activated currents and cold allodynia following partial nerve ligation.
 
Interactions
Hcn1 interacts with 216 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (39 annotations)
Process apical protein localization, cellular response to cAMP, ...
Component axon, dendrite, ...
Function cAMP binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (6)    Tissues (6)   
Theiler Stages: 25, 27, 28
Assay TypeResults
RT-PCR 6
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(25) cDNA(24) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035649 (Evidence)
Ensembl Gene ModelENSMUSG00000021730 (Evidence)
Entrez Gene15165 (Evidence)
UniGene343429
DFCITC1588931, TC1603795, TC1641299
DoTSDT.101265452, DT.55115685, DT.94244952
NIA Mouse Gene IndexU015275, U015276
PDB3U0Z
Consensus CDS ProjectCCDS26793.1
International Mouse Knockout Project StatusHcn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035649 VEGA Gene Model | MGI Sequence Detail 374323 C57BL/6J ±  kb
transcript OTTMUST00000091246 VEGA | MGI Sequence Detail 3525 Not Applicable 
polypeptide OTTMUSP00000050239 VEGA | MGI Sequence Detail 910 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(3893 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018488 Cyclic nucleotide-binding, conserved site
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR005821 Ion transport domain
InterPro IPR013621 Ion transport N-terminal
InterPro IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000000705 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
References (Earliest) J:45084 Santoro B, et al., Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14815-20
(Latest) J:205051 Miller JA, et al., Conserved molecular signatures of neurogenesis in the hippocampal subgranular zone of rodents and primates. Development. 2013 Nov;140(22):4633-44
All references(77)
Other
accession IDs
MGI:2442891

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory