Hcn1
Gene Detail

Symbol Name ID

Hcn1 hyperpolarization-activated, cyclic nucleotide-gated K+ 1 MGI:1096392

Synonyms

Bcng1, C630013B14Rik, HAC2

Feature Type

protein coding gene

Genetic Map

Chromosome 13

66.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr13:117602480-117976802 bp, + strand From VEGA annotation of GRCm38   374323 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:32093  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel proteins
Gene Tree: Hcn1

Human homologs

Human Homolog		HCN1, hyperpolarization activated cyclic nucleotide-gated potassium channel 1
NCBI Gene ID		348980
neXtProt AC		NX_O60741
Human Synonyms		BCNG1, BCNG-1, HAC-2
Human Chr (Location)		5p12; chr5:45255052-45696220 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Mice homozygous for disruptions in this allele display learning deficiencies but are otherwise normal. Mice homozygous for another targeted knock-out exhibit deficit in hyperpolarization-activated currents and cold allodynia following partial nerve ligation.

 

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	apical protein localization, ion transport, ...
Component	axon, dendrite, ...
Function	cAMP binding, ion channel activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (6)    Tissues (4)   
Theiler Stages: 25, 28

Assay Type	Results
RT-PCR	6

cDNA source data(24)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(25) cDNA(24) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000035649 (Evidence)
Ensembl Gene Model	ENSMUSG00000021730 (Evidence)
Entrez Gene	15165 (Evidence)
UniGene	343429
DFCI	TC1588931, TC1603795, TC1641299
DoTS	DT.101265452, DT.55115685, DT.94244952
NIA Mouse Gene Index	U015275, U015276
PDB	3U0Z
Consensus CDS Project	CCDS26793.1
International Mouse Knockout Project Status	Hcn1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035649	VEGA Gene Model | MGI Sequence Detail	374323	C57BL/6J
transcript	OTTMUST00000091246	VEGA | MGI Sequence Detail	3525	Not Applicable
polypeptide	OTTMUSP00000050239	VEGA | MGI Sequence Detail	910	Not Applicable

All sequences(27) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(1567 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR018488	Cyclic nucleotide-binding, conserved site
InterPro	IPR000595	Cyclic nucleotide-binding domain
InterPro	IPR018490	Cyclic nucleotide-binding-like
InterPro	IPR005821	Ion transport domain
InterPro	IPR013621	Ion transport N-terminal
InterPro	IPR003938	Potassium channel, voltage-dependent, EAG/ELK/ERG
InterPro	IPR014710	RmlC-like jelly roll fold
Protein Ontology	PR:000000705	potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

References

(Earliest) J:45084 Santoro B, et al., Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14815-20
(Latest) J:192134 Ramakrishnan NA, et al., HCN1 and HCN2 proteins are expressed in cochlear hair cells: HCN1 can form a ternary complex with protocadherin 15 CD3 and F-actin-binding filamin A or can interact with HCN2. J Biol Chem. 2012 Nov 2;287(45):37628-46
All references(72)

Other accession IDs

MGI:2442891