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Hcn1 Gene Detail
Summary
  • Symbol
    Hcn1
  • Name
    hyperpolarization-activated, cyclic nucleotide-gated K+ 1
  • Synonyms
    Bcng1, C630013B14Rik, HAC2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1096392
    NCBI Gene: 15165
  • Gene Overview
    MyGene.info: HCN1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:117602320-117981028 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 66.34 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3925 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1096392
protein coding gene Chr13:117602320-117987418 (.)
129S1/SvImJ MGP_129S1SvImJ_G0020965
protein coding gene Chr13:120534967-120939839 (+)
A/J MGP_AJ_G0020915
protein coding gene Chr13:115623020-116018543 (+)
AKR/J MGP_AKRJ_G0020890
protein coding gene Chr13:119064262-119455608 (+)
BALB/cJ MGP_BALBcJ_G0020915
protein coding gene Chr13:116341321-116736830 (+)
C3H/HeJ MGP_C3HHeJ_G0020704
protein coding gene Chr13:118902928-119290946 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021351
protein coding gene Chr13:123975371-124379141 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018920
protein coding gene Chr13:110758815-111121361 (+)
CAST/EiJ MGP_CASTEiJ_G0020223
protein coding gene Chr13:118706373-119121411 (+)
CBA/J MGP_CBAJ_G0020666
protein coding gene Chr13:128816140-129269194 (+)
DBA/2J MGP_DBA2J_G0020789
protein coding gene Chr13:115268707-115654648 (+)
FVB/NJ MGP_FVBNJ_G0020773
protein coding gene Chr13:113907563-114292565 (+)
LP/J MGP_LPJ_G0020865
protein coding gene Chr13:120497331-120887471 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020801
protein coding gene Chr13:129188975-129699483 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021387
protein coding gene Chr13:118556242-118962634 (+)
PWK/PhJ MGP_PWKPhJ_G0019976
protein coding gene Chr13:114142065-114530387 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019799
protein coding gene Chr13:114924917-115362827 (+)
WSB/EiJ MGP_WSBEiJ_G0020281
protein coding gene Chr13:119227282-119646354 (+)



Homology
more
  • Human Ortholog
    HCN1, hyperpolarization activated cyclic nucleotide gated potassium channel 1
  • Vertebrate Orthologs
    8
  • Human Ortholog
    HCN1, hyperpolarization activated cyclic nucleotide gated potassium channel 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BCNG1, BCNG-1, EIEE24, HAC-2
  • Links
    NCBI Gene ID: 348980
    neXtProt AC: NX_O60741
    UniProt: O60741

  • Chr Location
    5p12; chr5:45254950-45696118 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Hcn1 mouse models

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 3 alleles in 5 genetic backgrounds
    6 phenotypes from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this allele display learning deficiencies but are otherwise normal. Mice homozygous for another targeted knock-out exhibit deficit in hyperpolarization-activated currents and cold allodynia following partial nerve ligation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15165 NCBI Gene Model | MGI Sequence Detail 378709 C57BL/6J ±  kb
    transcript NM_010408 RefSeq | MGI Sequence Detail 7911 C57BL/6  
    polypeptide O88704 UniProt | EBI | MGI Sequence Detail 910 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      1 Sequence
    • Protein Ontology
      PR:000000705 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
    • PDB
    • InterPro Domains
      IPR018488 Cyclic nucleotide-binding, conserved site
      IPR000595 Cyclic nucleotide-binding domain
      IPR018490 Cyclic nucleotide-binding-like
      IPR005821 Ion transport domain
      IPR013621 Ion transport N-terminal
      IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
      IPR030169 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
      IPR014710 RmlC-like jelly roll fold
      IPR027359 Voltage-dependent channel domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 27
      cDNA 26
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2442891
    References
    more
    • Summaries
      All 97
      Developmental Gene Expression 10
      Diseases 1
      Gene Ontology 8
      Phenotypes 38
    • Earliest
      J:45084 Santoro B, et al., Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14815-20
    • Latest
      J:257775 Mallory CS, et al., Grid scale drives the scale and long-term stability of place maps. Nat Neurosci. 2018 Feb;21(2):270-282

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory