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Hcn1
Gene Detail
Symbol

Name
ID
Hcn1
hyperpolarization-activated, cyclic nucleotide-gated K+ 1
MGI:1096392
Synonyms
Bcng1, C630013B14Rik, HAC2
Feature Type
protein coding gene
Genetic Map
Chromosome 13
66.34 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr13:117602480-117976802 bp, + strand
From VEGA annotation of GRCm38

  374323 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:32093  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HCN1
Protein SuperFamily: potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel proteins
Gene Tree: Hcn1

Human
homologs
HCN1, hyperpolarization activated cyclic nucleotide gated potassium channel 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 348980
neXtProt AC: NX_O60741

Human Synonyms: BCNG1, BCNG-1, EIEE24, HAC-2

Human Chr (Location): 5p12; chr5:45254950-45696118 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human HCN1

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this allele display learning deficiencies but are otherwise normal. Mice homozygous for another targeted knock-out exhibit deficit in hyperpolarization-activated currents and cold allodynia following partial nerve ligation.
 
Interactions
Hcn1 interacts with 216 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (59 annotations)
Process apical protein localization, cellular response to cAMP, ...
Component apical dendrite, axon, ...
Function cAMP binding, identical protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (6)    Tissues (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 6
cDNA source data(24)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase hcn1    NEW 
Molecular
reagents
All nucleic(25) cDNA(24) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000035649 (Evidence)
Ensembl Gene Model ENSMUSG00000021730 (Evidence)
Entrez Gene 15165 (Evidence)
UniGene 343429
DFCI TC1641299, TC1603795, TC1588931
DoTS DT.94244952, DT.55115685, DT.101265452
NIA Mouse Gene Index U015276, U015275
PDB 3U0Z
Consensus CDS Project CCDS26793.1
International Mouse Phenotyping Consortium Status Hcn1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035649 VEGA Gene Model | MGI Sequence Detail 374323 C57BL/6J ±  kb
transcript OTTMUST00000091246 VEGA | MGI Sequence Detail 3525 Not Applicable 
polypeptide OTTMUSP00000050239 VEGA | MGI Sequence Detail 910 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(3893 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018488 Cyclic nucleotide-binding, conserved site
InterPro IPR000595 Cyclic nucleotide-binding domain
InterPro IPR018490 Cyclic nucleotide-binding-like
InterPro IPR005821 Ion transport domain
InterPro IPR013621 Ion transport N-terminal
InterPro IPR003938 Potassium channel, voltage-dependent, EAG/ELK/ERG
InterPro IPR014710 RmlC-like jelly roll fold
Protein Ontology PR:000000705 potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1
References
(Earliest) J:45084 Santoro B, et al., Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14815-20
(Latest) J:219164 Fenske S, et al., Sick sinus syndrome in HCN1-deficient mice. Circulation. 2013 Dec 17;128(24):2585-94
All references(79)
Other
accession IDs
MGI:2442891

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory