Sequence Detail

ID/Version

O88704 O54899 Q9D613 (UniProt | EBI)

Last sequence update: 1998-11-01
Last annotation update: 2026-06-10

Sequence description from provider

RecName: Full=Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1;AltName: Full=Brain cyclic nucleotide-gated channel 1 {ECO:0000303|PubMed:9405696}; Short=BCNG-1 {ECO:0000303|PubMed:9405696};AltName: Full=Hyperpolarizat

Provider

SWISS-PROT

Sequence

Polypeptide 910 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Hcn1	hyperpolarization activated cyclic nucleotide gated potassium channel 1	109	108	2	13

Sequence references in MGI

J:45084 Santoro B, et al., Interactive cloning with the SH3 domain of N-src identifies a new brain specific ion channel protein, with homology to eag and cyclic nucleotide-gated channels. Proc Natl Acad Sci U S A. 1997 Dec 23;94(26):14815-20
J:47845 Santoro B, et al., Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain. Cell. 1998 May 29;93(5):717-29
J:48083 Ludwig A, et al., A family of hyperpolarization-activated mammalian cation channels. Nature. 1998 Jun 11;393(6685):587-91
J:86763 Nolan MF, et al., The hyperpolarization-activated HCN1 channel is important for motor learning and neuronal integration by cerebellar Purkinje cells. Cell. 2003 Nov 26;115(5):551-64
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:202583 Lolicato M, et al., Tetramerization dynamics of C-terminal domain underlies isoform-specific cAMP gating in hyperpolarization-activated cyclic nucleotide-gated channels. J Biol Chem. 2011 Dec 30;286(52):44811-20
J:219164 Fenske S, et al., Sick sinus syndrome in HCN1-deficient mice. Circulation. 2013 Dec 17;128(24):2585-94
J:226018 Kole MJ, et al., Selective Loss of Presynaptic Potassium Channel Clusters at the Cerebellar Basket Cell Terminal Pinceau in Adam11 Mutants Reveals Their Role in Ephaptic Control of Purkinje Cell Firing. J Neurosci. 2015 Aug 12;35(32):11433-44
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:383810 Wainger BJ, et al., Molecular mechanism of cAMP modulation of HCN pacemaker channels. Nature. 2001 Jun 14;411(6839):805-10
J:383823 Stevens DR, et al., Hyperpolarization-activated channels HCN1 and HCN4 mediate responses to sour stimuli. Nature. 2001 Oct 11;413(6856):631-5
J:384334 Proenza C, et al., Different roles for the cyclic nucleotide binding domain and amino terminus in assembly and expression of hyperpolarization-activated, cyclic nucleotide-gated channels. J Biol Chem. 2002 Aug 16;277(33):29634-42