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Nrxn2
Gene Detail
 Symbol
Name
ID
Nrxn2
neurexin II
MGI:1096362
Synonyms 6430591O13Rik, mKIAA0921, neurexin II alpha, neurexin II beta
Feature Type protein coding gene
Genetic Map
Chromosome 19
4.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr19:6418731-6544169 bp, + strand
From VEGA annotation of GRCm38

  125439 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:86984  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: neurexin
Gene Tree: Nrxn2

Human
homologs
Human Homolog NRXN2, neurexin 2
NCBI Gene ID 9379
neXtProt AC  NX_P58401, NX_Q9P2S2
Human Chr (Location)  11q13; chr11:64606174-64723188 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(19) : Gene trapped(16) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are generally non-viable; surviving homozygotes show a 30-40% decrease in body weight and their inhibitory postsynaptic currents (IPSCs) are decreased in cortical slice cultures.
 
Interactions
Nrxn2 interacts with 207 markers (Mir7-1, Mir20a, Mir22, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process adult behavior, neurotransmitter secretion, ...
Component cell, integral component of membrane, ...
Function calcium channel regulator activity, protein binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (20)    Tissues (14)   
Theiler Stages: 20, 22, 24, 26, 27, 28
Assay TypeResults
RNA in situ 20
cDNA source data(16)
External Resources: GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(17)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000018624 (Evidence)
Ensembl Gene ModelENSMUSG00000033768 (Evidence)
Entrez Gene18190 (Evidence)
NIA Mouse Gene IndexU038686, U066536
Consensus CDS ProjectCCDS57132.1, CCDS57133.1
International Mouse Knockout Project StatusNrxn2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018624 VEGA Gene Model | MGI Sequence Detail 125439 C57BL/6J ±  kb
transcript OTTMUST00000081789 VEGA | MGI Sequence Detail 6314 Not Applicable 
polypeptide OTTMUSP00000043798 VEGA | MGI Sequence Detail 1710 Not Applicable 

For the selected sequences
All sequences(91) RefSeq(6) UniProt(12)
Polymorphisms SNPs within 2kb(489 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR001791 Laminin G domain
InterPro IPR027160 Neurexin-2-alpha
InterPro IPR003585 Neurexin/syndecan/glycophorin C
References (Earliest) J:24533 Puschel AW, et al., Neurexins are differentially expressed in the embryonic nervous system of mice. J Neurosci. 1995 Apr;15(4):2849-56
(Latest) J:171950 Joo JY, et al., Differential interactions of cerebellin precursor protein (Cbln) subtypes and neurexin variants for synapse formation of cortical neurons. Biochem Biophys Res Commun. 2011 Mar 25;406(4):627-32
All references(43)
Other
accession IDs
MGI:2444066

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory